$\frac{\frac{\mathrm{ADP}}{2}+\mathrm{ATP}}{\mathrm{sumAXP}}$ $\mathrm{P2G}+\mathrm{P3G}$ $\frac{\sqrt{(1-\frac{\mathrm{NA}\mathrm{sumPXG}\mathrm{volume}}{1618640})^2+(1-\frac{\mathrm{NA}\mathrm{volume}\mathrm{DHAP}}{3496987})^2+(1-\frac{\mathrm{NA}\mathrm{volume}\mathrm{F16bP}}{13800392})^2+(1-\frac{\mathrm{NA}\mathrm{volume}\mathrm{F6P}}{708930})^2+(1-\frac{\mathrm{NA}\mathrm{volume}\mathrm{G6P}}{2326001})^2+(1-\frac{\mathrm{NA}\mathrm{volume}\mathrm{GAP}}{951170})^2+(1-\frac{\mathrm{NA}\mathrm{volume}\mathrm{GLC}}{18909525})^2+(1-\frac{\mathrm{NA}\mathrm{volume}\mathrm{PEP}}{1836769})^2+(1-\frac{\mathrm{NA}\mathrm{volume}\mathrm{PYR}}{6348755})^2}}{3}$ $\frac{\mathrm{ADH1}\mathrm{ADHADH1kcat}(-\left(\frac{\mathrm{EtOH}\mathrm{NAD}}{\mathrm{ADHADH1Kacald}\mathrm{ADHADH1Kinadh}\mathrm{KeqADH}}\right)+\frac{\mathrm{AcAld}\mathrm{NADH}}{\mathrm{ADHADH1Kacald}\mathrm{ADHADH1Kinadh}})}{1+\frac{\mathrm{ADHADH1Knad}\mathrm{EtOH}}{\mathrm{ADHADH1Ketoh}\mathrm{ADHADH1Kinad}}+\frac{\mathrm{ADHADH1Knadh}\mathrm{AcAld}}{\mathrm{ADHADH1Kacald}\mathrm{ADHADH1Kinadh}}+\frac{\mathrm{NAD}}{\mathrm{ADHADH1Kinad}}+\frac{\mathrm{EtOH}\mathrm{NAD}}{\mathrm{ADHADH1Ketoh}\mathrm{ADHADH1Kinad}}+\frac{\mathrm{ADHADH1Knadh}\mathrm{AcAld}\mathrm{NAD}}{\mathrm{ADHADH1Kacald}\mathrm{ADHADH1Kinad}\mathrm{ADHADH1Kinadh}}+\frac{\mathrm{EtOH}\mathrm{AcAld}\mathrm{NAD}}{\mathrm{ADHADH1Ketoh}\mathrm{ADHADH1Kiacald}\mathrm{ADHADH1Kinad}}+\frac{\mathrm{NADH}}{\mathrm{ADHADH1Kinadh}}+\frac{\mathrm{ADHADH1Knad}\mathrm{EtOH}\mathrm{NADH}}{\mathrm{ADHADH1Ketoh}\mathrm{ADHADH1Kinad}\mathrm{ADHADH1Kinadh}}+\frac{\mathrm{AcAld}\mathrm{NADH}}{\mathrm{ADHADH1Kacald}\mathrm{ADHADH1Kinadh}}+\frac{\mathrm{EtOH}\mathrm{AcAld}\mathrm{NADH}}{\mathrm{ADHADH1Kacald}\mathrm{ADHADH1Kietoh}\mathrm{ADHADH1Kinadh}}}$ $\frac{\mathrm{ADH5}\mathrm{ADHADH5kcat}(-\left(\frac{\mathrm{EtOH}\mathrm{NAD}}{\mathrm{ADHADH5Kacald}\mathrm{ADHADH5Kinadh}\mathrm{KeqADH}}\right)+\frac{\mathrm{AcAld}\mathrm{NADH}}{\mathrm{ADHADH5Kacald}\mathrm{ADHADH5Kinadh}})}{1+\frac{\mathrm{ADHADH5Knad}\mathrm{EtOH}}{\mathrm{ADHADH5Ketoh}\mathrm{ADHADH5Kinad}}+\frac{\mathrm{ADHADH5Knadh}\mathrm{AcAld}}{\mathrm{ADHADH5Kacald}\mathrm{ADHADH5Kinadh}}+\frac{\mathrm{NAD}}{\mathrm{ADHADH5Kinad}}+\frac{\mathrm{EtOH}\mathrm{NAD}}{\mathrm{ADHADH5Ketoh}\mathrm{ADHADH5Kinad}}+\frac{\mathrm{ADHADH5Knadh}\mathrm{AcAld}\mathrm{NAD}}{\mathrm{ADHADH5Kacald}\mathrm{ADHADH5Kinad}\mathrm{ADHADH5Kinadh}}+\frac{\mathrm{EtOH}\mathrm{AcAld}\mathrm{NAD}}{\mathrm{ADHADH5Ketoh}\mathrm{ADHADH5Kiacald}\mathrm{ADHADH5Kinad}}+\frac{\mathrm{NADH}}{\mathrm{ADHADH5Kinadh}}+\frac{\mathrm{ADHADH5Knad}\mathrm{EtOH}\mathrm{NADH}}{\mathrm{ADHADH5Ketoh}\mathrm{ADHADH5Kinad}\mathrm{ADHADH5Kinadh}}+\frac{\mathrm{AcAld}\mathrm{NADH}}{\mathrm{ADHADH5Kacald}\mathrm{ADHADH5Kinadh}}+\frac{\mathrm{EtOH}\mathrm{AcAld}\mathrm{NADH}}{\mathrm{ADHADH5Kacald}\mathrm{ADHADH5Kietoh}\mathrm{ADHADH5Kinadh}}}$ $\mathrm{AKk}(\mathrm{ADP}^2-\frac{\mathrm{AMP}\mathrm{ATP}}{\mathrm{AKKeq}})$ $\frac{\mathrm{ATPaseVmax}\mathrm{ATP}}{\mathrm{ATPaseKatp}(1+\frac{\mathrm{ATP}}{\mathrm{ATPaseKatp}})}$ $\frac{\mathrm{ENO1}\mathrm{ENOENO1kcat}(\frac{\mathrm{P2G}}{\mathrm{ENOENO1Kp2g}}-\frac{\mathrm{PEP}}{\mathrm{ENOENO1Kp2g}\mathrm{KeqENO}})}{1+\frac{\mathrm{P2G}}{\mathrm{ENOENO1Kp2g}}+\frac{\mathrm{PEP}}{\mathrm{ENOENO1Kpep}}}$ $\frac{\mathrm{ENO2}\mathrm{ENOENO2kcat}(\frac{\mathrm{P2G}}{\mathrm{ENOENO2Kp2g}}-\frac{\mathrm{PEP}}{\mathrm{ENOENO2Kp2g}\mathrm{KeqENO}})}{1+\frac{\mathrm{P2G}}{\mathrm{ENOENO2Kp2g}}+\frac{\mathrm{PEP}}{\mathrm{ENOENO2Kpep}}}$ $\frac{\mathrm{FBA1}\mathrm{FBAkcat}(\frac{\mathrm{F16bP}}{\mathrm{FBAKf16bp}}-\frac{\mathrm{DHAP}\mathrm{GAP}}{\mathrm{FBAKeq}\mathrm{FBAKf16bp}})}{1+\frac{\mathrm{DHAP}}{\mathrm{FBAKdhap}}+\frac{\mathrm{F16bP}}{\mathrm{FBAKf16bp}}+\frac{\mathrm{GAP}}{\mathrm{FBAKgap}}+\frac{\mathrm{DHAP}\mathrm{GAP}}{\mathrm{FBAKdhap}\mathrm{FBAKgap}}+\frac{\mathrm{F16bP}\mathrm{GAP}}{\mathrm{FBAKf16bp}\mathrm{FBAKigap}}}$ $\frac{\mathrm{GPDVmax}(-\left(\frac{\mathrm{G3P}\mathrm{NAD}}{\mathrm{GPDKeq}}\right)+\mathrm{DHAP}\mathrm{NADH})}{\mathrm{GPDKdhap}\mathrm{GPDKnadh}(1+\frac{\mathrm{ADP}}{\mathrm{GPDKadp}}+\frac{\mathrm{ATP}}{\mathrm{GPDKatp}}+\frac{\mathrm{F16bP}}{\mathrm{GPDKfbp}})(1+\frac{\mathrm{DHAP}}{\mathrm{GPDKdhap}}+\frac{\mathrm{G3P}}{\mathrm{GPDKg3p}})(1+\frac{\mathrm{NAD}}{\mathrm{GPDKnad}}+\frac{\mathrm{NADH}}{\mathrm{GPDKnadh}})}$ $\frac{\mathrm{GPM1}\mathrm{GPMkcat}(-\left(\frac{\mathrm{P2G}}{\mathrm{GPMKeq}\mathrm{GPMKp3g}}\right)+\frac{\mathrm{P3G}}{\mathrm{GPMKp3g}})}{1+\frac{\mathrm{P2G}}{\mathrm{GPMKp2g}}+\frac{\mathrm{P3G}}{\mathrm{GPMKp3g}}}$ $\frac{\mathrm{GPPVmax}\mathrm{G3P}}{\mathrm{GPPKg3p}(1+\frac{\mathrm{G3P}}{\mathrm{GPPKg3p}})}$ $\frac{\mathrm{GLK1}\mathrm{HXKGLK1kcat}(-\left(\frac{\mathrm{ADP}\mathrm{G6P}}{\mathrm{HXKGLK1Katp}\mathrm{HXKGLK1Kglc}\mathrm{KeqHXK}}\right)+\frac{\mathrm{ATP}\mathrm{GLC}}{\mathrm{HXKGLK1Katp}\mathrm{HXKGLK1Kglc}})}{(1+\frac{\mathrm{ADP}}{\mathrm{HXKGLK1Kadp}}+\frac{\mathrm{ATP}}{\mathrm{HXKGLK1Katp}})(1+\frac{\mathrm{G6P}}{\mathrm{HXKGLK1Kg6p}}+\frac{\mathrm{GLC}}{\mathrm{HXKGLK1Kglc}})}$ $\frac{\mathrm{HXK1}\mathrm{HXKHXK1kcat}(-\left(\frac{\mathrm{ADP}\mathrm{G6P}}{\mathrm{HXKHXK1Katp}\mathrm{HXKHXK1Kglc}\mathrm{KeqHXK}}\right)+\frac{\mathrm{ATP}\mathrm{GLC}}{\mathrm{HXKHXK1Katp}\mathrm{HXKHXK1Kglc}})}{(1+\frac{\mathrm{ADP}}{\mathrm{HXKHXK1Kadp}}+\frac{\mathrm{ATP}}{\mathrm{HXKHXK1Katp}})(1+\frac{\mathrm{G6P}}{\mathrm{HXKHXK1Kg6p}}+\frac{\mathrm{GLC}}{\mathrm{HXKHXK1Kglc}}+\frac{\mathrm{T6P}}{\mathrm{HXKHXK1Kit6p}})}$ $\frac{\mathrm{HXK2}\mathrm{HXKHXK2kcat}(-\left(\frac{\mathrm{ADP}\mathrm{G6P}}{\mathrm{HXKHXK2Katp}\mathrm{HXKHXK2Kglc}\mathrm{KeqHXK}}\right)+\frac{\mathrm{ATP}\mathrm{GLC}}{\mathrm{HXKHXK2Katp}\mathrm{HXKHXK2Kglc}})}{(1+\frac{\mathrm{ADP}}{\mathrm{HXKHXK2Kadp}}+\frac{\mathrm{ATP}}{\mathrm{HXKHXK2Katp}})(1+\frac{\mathrm{G6P}}{\mathrm{HXKHXK2Kg6p}}+\frac{\mathrm{GLC}}{\mathrm{HXKHXK2Kglc}}+\frac{\mathrm{T6P}}{\mathrm{HXKHXK2Kit6p}})}$ $\frac{\mathrm{HXTVmax}(\mathrm{GLCx}-\mathrm{GLC})}{\mathrm{HXTKglc}(1+\frac{\mathrm{GLCx}}{\mathrm{HXTKglc}}+\frac{\mathrm{GLC}}{\mathrm{HXTKglc}}+\frac{\mathrm{GLCx}\mathrm{HXTKi}\mathrm{GLC}}{\mathrm{HXTKglc}^2})}$ $\frac{\mathrm{PDC1}\mathrm{PDCPDC1kcat}\mathrm{PYR}}{\mathrm{PDCPDC1Kpyr}(1+\frac{\mathrm{PYR}}{\mathrm{PDCPDC1Kpyr}})}$ $\frac{\mathrm{PDC5}\mathrm{PDCPDC5kcat}\mathrm{PYR}}{\mathrm{PDCPDC5Kpyr}(1+\frac{\mathrm{PYR}}{\mathrm{PDCPDC5Kpyr}})}$ $\frac{\mathrm{PDC6}\mathrm{PDCPDC6kcat}\mathrm{PYR}}{\mathrm{PDCPDC6Kpyr}(1+\frac{\mathrm{PYR}}{\mathrm{PDCPDC6Kpyr}})}$ $\frac{\mathrm{PFKgR}\mathrm{PFKkcat}(\mathrm{PFK1}+\mathrm{PFK2}-\left|\mathrm{PFK1}-\mathrm{PFK2}\right|)\mathrm{ATP}(1-\frac{\mathrm{ADP}\mathrm{F16bP}}{\mathrm{PFKKeq}\mathrm{ATP}\mathrm{F6P}})\mathrm{F6P}(1+\frac{\mathrm{ADP}}{\mathrm{PFKKadp}}+\frac{\mathrm{ATP}}{\mathrm{PFKKatp}}+\frac{\mathrm{F16bP}}{\mathrm{PFKKf16}}+\frac{\mathrm{PFKgR}\mathrm{ADP}\mathrm{F16bP}}{\mathrm{PFKKadp}\mathrm{PFKKf16}}+\frac{\mathrm{F6P}}{\mathrm{PFKKf6p}}+\frac{\mathrm{PFKgR}\mathrm{ATP}\mathrm{F6P}}{\mathrm{PFKKatp}\mathrm{PFKKf6p}})}{2\mathrm{PFKKatp}\mathrm{PFKKf6p}(\frac{\mathrm{PFKL0}(1+\frac{\mathrm{PFKCamp}\mathrm{AMP}}{\mathrm{PFKKamp}})^2(1+\frac{\mathrm{PFKCatp}\mathrm{ATP}}{\mathrm{PFKKatp}})^2(1+\frac{\mathrm{PFKCiatp}\mathrm{ATP}}{\mathrm{PFKKiatp}})^2(1+\frac{\mathrm{F26bP}\mathrm{PFKCf26}}{\mathrm{PFKKf26}}+\frac{\mathrm{PFKCf16}\mathrm{F16bP}}{\mathrm{PFKKf16}})^2}{(1+\frac{\mathrm{AMP}}{\mathrm{PFKKamp}})^2(1+\frac{\mathrm{ATP}}{\mathrm{PFKKiatp}})^2(1+\frac{\mathrm{F26bP}}{\mathrm{PFKKf26}}+\frac{\mathrm{F16bP}}{\mathrm{PFKKf16}})^2}+(1+\frac{\mathrm{ADP}}{\mathrm{PFKKadp}}+\frac{\mathrm{ATP}}{\mathrm{PFKKatp}}+\frac{\mathrm{F16bP}}{\mathrm{PFKKf16}}+\frac{\mathrm{PFKgR}\mathrm{ADP}\mathrm{F16bP}}{\mathrm{PFKKadp}\mathrm{PFKKf16}}+\frac{\mathrm{F6P}}{\mathrm{PFKKf6p}}+\frac{\mathrm{PFKgR}\mathrm{ATP}\mathrm{F6P}}{\mathrm{PFKKatp}\mathrm{PFKKf6p}})^2)}$ $\frac{\mathrm{PGI1}\mathrm{PGIkcat}(-\left(\frac{\mathrm{F6P}}{\mathrm{PGIKeq}\mathrm{PGIKg6p}}\right)+\frac{\mathrm{G6P}}{\mathrm{PGIKg6p}})}{1+\frac{\mathrm{F6P}}{\mathrm{PGIKf6p}}+\frac{\mathrm{G6P}}{\mathrm{PGIKg6p}}}$ $\frac{\mathrm{PGK1}\mathrm{PGKkcat}\left(\frac{\mathrm{ADP}}{\mathrm{PGKKadp}}\right)^{(-1+\mathrm{PGKnHadp})}(\frac{\mathrm{ADP}\mathrm{BPG}}{\mathrm{PGKKadp}\mathrm{PGKKbpg}}-\frac{\mathrm{ATP}\mathrm{P3G}}{\mathrm{PGKKadp}\mathrm{PGKKbpg}\mathrm{PGKKeq}})}{(1+\left(\frac{\mathrm{ADP}}{\mathrm{PGKKadp}}\right)^{\mathrm{PGKnHadp}}+\frac{\mathrm{ATP}}{\mathrm{PGKKatp}})(1+\frac{\mathrm{BPG}}{\mathrm{PGKKbpg}}+\frac{\mathrm{P3G}}{\mathrm{PGKKp3g}})}$ $\frac{\mathrm{PGMVmax}\mathrm{rescaleTRH}(-\left(\frac{\mathrm{G1P}}{\mathrm{PGMKeq}\mathrm{PGMKg6p}}\right)+\frac{\mathrm{G6P}}{\mathrm{PGMKg6p}})}{1+\frac{\mathrm{G1P}}{\mathrm{PGMKg1p}}+\frac{\mathrm{G6P}}{\mathrm{PGMKg6p}}}$ $\frac{\mathrm{CDC19}\mathrm{PYKCDC19kcat}(\mathrm{ADP}\mathrm{PEP}-\frac{\mathrm{ATP}\mathrm{PYR}}{\mathrm{KeqPYK}})}{\mathrm{PYKCDC19Kadp}\mathrm{PYKCDC19Kpep}(1+\frac{\mathrm{ADP}}{\mathrm{PYKCDC19Kadp}}+\frac{\mathrm{ATP}}{\mathrm{PYKCDC19Katp}})(1+\frac{\mathrm{PYKCDC19L0}(1+\frac{\mathrm{ATP}}{\mathrm{PYKCDC19Kiatp}})}{1+\frac{\mathrm{F16bP}}{\mathrm{PYKCDC19Kf16p}}}+\frac{\mathrm{PEP}}{\mathrm{PYKCDC19Kpep}}+\frac{\mathrm{PYR}}{\mathrm{PYKCDC19Kpyr}})}$ $\frac{\mathrm{PYK2}\mathrm{PYKPYK2kcat}(\mathrm{ADP}\mathrm{PEP}-\frac{\mathrm{ATP}\mathrm{PYR}}{\mathrm{KeqPYK}})}{\mathrm{PYKPYK2Kadp}\mathrm{PYKPYK2Kpep}(1+\frac{\mathrm{ADP}}{\mathrm{PYKPYK2Kadp}}+\frac{\mathrm{ATP}}{\mathrm{PYKPYK2Katp}})(1+\frac{\mathrm{PYKPYK2L0}(1+\frac{\mathrm{ATP}}{\mathrm{PYKPYK2Kiatp}})}{1+\frac{\mathrm{F16bP}}{\mathrm{PYKPYK2Kf16p}}}+\frac{\mathrm{PEP}}{\mathrm{PYKPYK2Kpep}}+\frac{\mathrm{PYR}}{\mathrm{PYKPYK2Kpyr}})}$ $\frac{\mathrm{TDH1}\mathrm{TDHTDH1kcat}(\frac{\mathrm{GAP}\mathrm{NAD}}{\mathrm{TDHTDH1Kgap}\mathrm{TDHTDH1Knad}}-\frac{\mathrm{BPG}\mathrm{NADH}}{\mathrm{KeqTDH}\mathrm{TDHTDH1Kgap}\mathrm{TDHTDH1Knad}})}{(1+\frac{\mathrm{BPG}}{\mathrm{TDHTDH1Kbpg}}+\frac{\mathrm{GAP}}{\mathrm{TDHTDH1Kgap}})(1+\frac{\mathrm{NAD}}{\mathrm{TDHTDH1Knad}}+\frac{\mathrm{NADH}}{\mathrm{TDHTDH1Knadh}})}$ $\frac{\mathrm{TDH2}\mathrm{TDHTDH2kcat}(\frac{\mathrm{GAP}\mathrm{NAD}}{\mathrm{TDHTDH2Kgap}\mathrm{TDHTDH2Knad}}-\frac{\mathrm{BPG}\mathrm{NADH}}{\mathrm{KeqTDH}\mathrm{TDHTDH2Kgap}\mathrm{TDHTDH2Knad}})}{(1+\frac{\mathrm{BPG}}{\mathrm{TDHTDH2Kbpg}}+\frac{\mathrm{GAP}}{\mathrm{TDHTDH2Kgap}})(1+\frac{\mathrm{NAD}}{\mathrm{TDHTDH2Knad}}+\frac{\mathrm{NADH}}{\mathrm{TDHTDH2Knadh}})}$ $\frac{\mathrm{TDH3}\mathrm{TDHTDH3kcat}(\frac{\mathrm{GAP}\mathrm{NAD}}{\mathrm{TDHTDH3Kgap}\mathrm{TDHTDH3Knad}}-\frac{\mathrm{BPG}\mathrm{NADH}}{\mathrm{KeqTDH}\mathrm{TDHTDH3Kgap}\mathrm{TDHTDH3Knad}})}{(1+\frac{\mathrm{BPG}}{\mathrm{TDHTDH3Kbpg}}+\frac{\mathrm{GAP}}{\mathrm{TDHTDH3Kgap}})(1+\frac{\mathrm{NAD}}{\mathrm{TDHTDH3Knad}}+\frac{\mathrm{NADH}}{\mathrm{TDHTDH3Knadh}})}$ $\mathrm{TPIk}(\mathrm{DHAP}-\frac{\mathrm{GAP}}{\mathrm{TPIKeq}})$ $\frac{\mathrm{rescaleTRH}\mathrm{TPPVmax}\mathrm{T6P}}{\mathrm{TPPKt6p}(1+\frac{\mathrm{T6P}}{\mathrm{TPPKt6p}})}$ $\frac{\mathrm{rescaleTRH}\mathrm{TPSVmax}\mathrm{G6P}\mathrm{UDG}}{\mathrm{TPSKg6p}\mathrm{TPSKudg}(1+\frac{\mathrm{G6P}}{\mathrm{TPSKg6p}})(1+\frac{\mathrm{UDG}}{\mathrm{TPSKudg}})}$ $\frac{\mathrm{rescaleTRH}\mathrm{UGPVmax}\mathrm{G1P}\mathrm{UTP}}{\mathrm{UGPKg1p}\mathrm{UGPKutp}(\frac{\mathrm{UGPKiutp}}{\mathrm{UGPKutp}}+\frac{\mathrm{G1P}}{\mathrm{UGPKg1p}}+\frac{\mathrm{UGPKiutp}\mathrm{UDG}}{\mathrm{UGPKiudg}\mathrm{UGPKutp}}+\frac{\mathrm{G1P}\mathrm{UDG}}{\mathrm{UGPKg1p}\mathrm{UGPKiudg}}+\frac{\mathrm{UTP}}{\mathrm{UGPKutp}}+\frac{\mathrm{G1P}\mathrm{UTP}}{\mathrm{UGPKg1p}\mathrm{UGPKutp}})}$ $\mathrm{acetatebranchk}\mathrm{AcAld}\mathrm{NAD}$ $\mathrm{succinatebranchk}\mathrm{NAD}\mathrm{PYR}$ $\mathrm{rescaleTRH}\mathrm{udptoutpk}\mathrm{ATP}\mathrm{UDP}$