v_1

x2 = x3

v_10

x6 + x16 = x10

v_100

x60 + x81 = x85

v_101

x55 + x60 = x85

v_102

x15 = x17

v_103

x32 = x63

v_104

x33 = x64

v_105

x25 = x19

v_106

x12 + x25 = x88

v_107

x9 + x19 = x88

v_108

x27 = x20

v_109

x12 + x27 = x89

v_11

{2.0}x10 = x11

v_110

x9 + x20 = x89

v_111

x29 = x21

v_112

x12 + x29 = x90

v_113

x9 + x21 = x90

v_114

x34 = x65

v_115

x12 + x34 = x91

v_116

x9 + x65 = x91

v_117

x35 = x66

v_118

x12 + x35 = x92

v_119

x9 + x66 = x92

v_12

x11 = x8

v_120

x36 = x67

v_121

x12 + x36 = x93

v_122

x9 + x67 = x93

v_123

x37 = x68

v_124

x12 + x37 = x94

v_125

x9 + x68 = x94

v_126

x25 + x59 = x95

v_127

x19 + x83 = x96

v_128

x35 + x59 = x97

v_129

x66 + x83 = x98

v_13

ext = x2

v_130

x24 + x59 = x101

v_131

x24 + x83 = x102

v_132

x17 = x87

v_133

x18 = x87

v_134

x19 = x87

v_135

x20 = x87

v_136

x21 = x87

v_137

x63 = x87

v_138

x64 = x87

v_139

x65 = x87

v_14

x8 + x14 = x17

v_140

x66 = x87

v_141

x67 = x87

v_142

x68 = x87

v_143

x59 + x99 = x95

v_144

x59 + x99 = x97

v_145

x59 + x103 = x101

v_146

x83 + x100 = x96

v_147

x83 + x100 = x98

v_148

x83 + x103 = x102

v_15

x9 = x12

v_16

x15 + x22 = x23

v_17

x23 + x24 = x25

v_18

x25 + x26 = x27

v_19

x25 + x28 = x27

v_2

{2.0}x3 = x4

v_20

x25 + x43 = x29

v_21

x25 + x26 = x29

v_22

x15 + x31 = x32

v_23

x32 = x33

v_24

x22 + x33 = x34

v_25

x24 + x34 = x35

v_26

x26 + x35 = x36

v_27

x28 + x35 = x36

v_28

x28 + x41 = x42

v_29

x43 + x45 = x42

v_3

x4 = x5

v_30

x35 + x43 = x37

v_31

x26 + x35 = x37

v_32

x15 + x38 = x35

v_33

x30 + x40 = x38

v_34

x15 + x30 = x25

v_35

x22 + x24 = x30

v_36

x40 = x31

v_37

x15 + x40 = x33

v_38

x22 + x40 = x39

v_39

x15 + x39 = x34

v_4

x12 + x23 = x7

v_40

x24 + x39 = x38

v_41

x30 + x33 = x35

v_42

x44 + x45 = x46

v_43

x41 + x44 = x46

v_44

x45 + x47 = x48

v_45

x45 + x49 = x48

v_46

x45 + x49 = x50

v_47

x45 + x51 = x50

v_48

x51 + x53 = x52

v_49

x49 + x53 = x52

v_5

x9 + x18 = x7

v_50

x49 + x53 = x54

v_51

x47 + x53 = x54

v_52

x51 + x55 = x56

v_53

x51 + x57 = x56

v_54

x51 + x57 = x58

v_55

x51 + x59 = x58

v_56

x59 + x60 = x61

v_57

x57 + x60 = x61

v_58

x57 + x60 = x62

v_59

x55 + x60 = x62

v_6

x2 = x6

v_60

x6 = x86

v_61

x16 = x13

v_62

x8 = x87

v_63

x17 + x22 = x18

v_64

x18 + x24 = x19

v_65

x19 + x26 = x20

v_66

x19 + x69 = x20

v_67

x19 + x71 = x21

v_68

x19 + x26 = x21

v_69

x17 + x31 = x63

v_7

x5 = x8

v_70

x63 = x64

v_71

x22 + x64 = x65

v_72

x24 + x65 = x66

v_73

x26 + x66 = x67

v_74

x66 + x69 = x67

v_75

x41 + x69 = x70

v_76

x71 + x72 = x70

v_77

x66 + x71 = x68

v_78

x26 + x66 = x68

v_79

x17 + x38 = x66

v_8

x5 + x14 = x15

v_80

x17 + x30 = x19

v_81

x17 + x40 = x64

v_82

x17 + x39 = x65

v_83

x30 + x64 = x66

v_84

x44 + x72 = x73

v_85

x41 + x44 = x73

v_86

x47 + x72 = x74

v_87

x72 + x75 = x74

v_88

x72 + x75 = x76

v_89

x72 + x77 = x76

v_9

x23 = x18

v_90

x53 + x77 = x78

v_91

x53 + x75 = x78

v_92

x53 + x75 = x79

v_93

x47 + x53 = x79

v_94

x55 + x77 = x80

v_95

x77 + x81 = x80

v_96

x77 + x81 = x82

v_97

x77 + x83 = x82

v_98

x60 + x83 = x84

v_99

x60 + x81 = x84

ext*

x10*

x100*

x101*

x102*

x103*

x11*

x12*

x13*

x14*

x15*

x16*

x17*

x18*

x19*

x2*

x20*

x21*

x22*

x23*

x24*

x25*

x26*

x27*

x28*

x29*

x3*

x30*

x31*

x32*

x33*

x34*

x35*

x36*

x37*

x38*

x39*

x4*

x40*

x41*

x42*

x43*

x44*

x45*

x46*

x47*

x48*

x49*

x5*

x50*

x51*

x52*

x53*

x54*

x55*

x56*

x57*

x58*

x59*

x6*

x60*

x61*

x62*

x63*

x64*

x65*

x66*

x67*

x68*

x69*

x7*

x70*

x71*

x72*

x73*

x74*

x75*

x76*

x77*

x78*

x79*

x8*

x80*

x81*

x82*

x83*

x84*

x85*

x86*

x87*

x88*

x89*

x9*

x90*

x91*

x92*

x93*

x94*

x95*

x96*

x97*

x98*

x99*

Assignment rules

k10b = k10/a/Vv

kd57 = k56/a/Vz*a*Vz*KmPase - kd56

k52 = (kd53 + kd52)/a/Vz/KmERK

kd49 = k48/a/Vz*a*Vz*KmPase - kd48

kd63 = kd24*0.5

k44 = (kd45 + kd44)/a/Vz/KmMEK

kd5 = ((-0.0000135)*(RT/((kd1/k1)/Lo + 1)) + 1.55)/60

Function definitions

Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.