$\frac{\frac{0.4(0.23+0.8e^{-0.0026\mathrm{SAM}})\mathrm{vmMATi}\frac{\mathrm{met}}{\mathrm{kmMATimet}}}{1+\frac{\mathrm{met}}{\mathrm{kmMATimet}}}(\mathrm{kiMATiGSSG}+66.71)}{\mathrm{kiMATiGSSG}+\mathrm{cGSSG}}$ $\frac{0.35}{200}\mathrm{ccys}^2$ $\frac{\frac{\mathrm{vmgcl}(\mathrm{cglut}\mathrm{ccys}-\frac{\mathrm{cglc}}{\mathrm{keqgcl}})}{\mathrm{kmgclccys}\mathrm{kmgclglut}+\mathrm{kmgclccys}\mathrm{cglut}+\mathrm{ccys}\mathrm{kmgclglut}(1+\frac{\mathrm{cGSH}}{\mathrm{kmgclgsh}}+\frac{\mathrm{cglut}}{\mathrm{kmgclglut}})+\frac{\mathrm{cglc}}{\mathrm{kmgclglc}}+\frac{\mathrm{cGSH}}{\mathrm{kmgclgsh}}}(\mathrm{kagcl}+\mathrm{H2O2})}{\mathrm{kagcl}+\mathrm{H2O2ss}}$ $\frac{\mathrm{vmgs}(\mathrm{cgly}\mathrm{cglc}-\frac{\mathrm{cGSH}}{\mathrm{keqgs}})}{\mathrm{kmgscglc}\mathrm{kmgscgly}+\mathrm{cglc}\mathrm{kmgscgly}+\mathrm{cgly}\mathrm{kmgscglc}(1+\frac{\mathrm{cglc}}{\mathrm{kmgscglc}})+\frac{\mathrm{cGSH}}{\mathrm{kpcgsh}}}$ $\mathrm{vmGPX}\left(\frac{\mathrm{cGSH}}{\mathrm{kmGPXgsh}+\mathrm{cGSH}}\right)^2\frac{\mathrm{H2O2}}{9\mathrm{kmGPXH2O2}+\mathrm{H2O2}}$ $\frac{\mathrm{vmgr}\frac{\mathrm{cGSSG}}{\mathrm{kmgrGSSG}}\frac{\mathrm{cNADPH}}{\mathrm{kmgrNADPH}}}{1+\frac{\mathrm{cGSSG}}{\mathrm{kmgrGSSG}}+\frac{\mathrm{cNADPH}}{\mathrm{kmgrNADPH}}+\frac{\mathrm{cGSSG}}{\mathrm{kmgrGSSG}}\frac{\mathrm{cNADPH}}{\mathrm{kmgrNADPH}}}$ $\frac{\frac{\mathrm{vmGSSGl}\mathrm{cGSSG}}{\mathrm{kmGSSGl}+\mathrm{cGSSG}}(\mathrm{kaGSSGl}+\mathrm{H2O2})}{\mathrm{kaGSSGl}+\mathrm{H2O2ss}}$ $\frac{\frac{\mathrm{vmGSSGh}\mathrm{cGSSG}}{\mathrm{kmGSSGh}+\mathrm{cGSSG}}(\mathrm{kaGSSGh}+\mathrm{H2O2})}{\mathrm{kaGSSGh}+\mathrm{H2O2ss}}$ $0.002\mathrm{cGSH}$ $\frac{\mathrm{vmgshoutl}\mathrm{cGSH}\mathrm{cGSH}\mathrm{cGSH}}{\mathrm{kmgshoutl}^3+\mathrm{cGSH}\mathrm{cGSH}\mathrm{cGSH}}$ $\frac{\mathrm{vmgshouth}\mathrm{cGSH}}{\mathrm{cGSH}+\mathrm{kmgshouth}}$ $\frac{\frac{\mathrm{vmMATiii}\mathrm{met}^{1.21}}{\mathrm{kmMATiiimet}+\mathrm{met}^{1.21}}(1+\frac{7.2\mathrm{SAM}^2}{\mathrm{kmMATiiiSAM}+\mathrm{SAM}^2})(\mathrm{kiMATiiiGSSG}+66.71)}{\mathrm{kiMATiiiGSSG}+\mathrm{cGSSG}}$ $0.1\mathrm{cGSSG}$ $\frac{\mathrm{vmglutin}\mathrm{bglut}}{\mathrm{kmbglut}+\mathrm{bglut}}-\mathrm{kglutin}\mathrm{cglut}$ $\frac{\mathrm{vmcysin}\mathrm{bcys}}{\mathrm{kcysinbcys}+\mathrm{bcys}}$ $\frac{\mathrm{vmserin}\mathrm{bser}}{\mathrm{kbser}+\mathrm{bser}}-\mathrm{krserin}\mathrm{cser}$ $\frac{\mathrm{vmglyin}\mathrm{bgly}}{\mathrm{kmbgly}+\mathrm{bgly}}-\mathrm{kcgly}\mathrm{cgly}$ $\frac{\mathrm{vmfgly}\mathrm{mgly}}{3(\mathrm{kgly}+\mathrm{mgly})}-\frac{\mathrm{vmrgly}\mathrm{cgly}}{\mathrm{kgly}+\mathrm{cgly}}$ $\frac{\mathrm{khcooh}\mathrm{mHCOOH}}{3}-\mathrm{khcooh}\mathrm{cHCOOH}$ $\frac{\mathrm{Vmser}\mathrm{mser}}{3(\mathrm{Kmsermser}+\mathrm{mser})}-\frac{\mathrm{Vmser}\mathrm{cser}}{\mathrm{Kmsermser}+\mathrm{cser}}$ $\frac{\mathrm{VmfcSHMT}\frac{\mathrm{cser}}{\mathrm{KmcSHMTcser}}\frac{\mathrm{cTHF}}{\mathrm{KmcSHMTcTHF}}}{1+\frac{\mathrm{cser}}{\mathrm{KmcSHMTcser}}+\frac{\mathrm{cTHF}}{\mathrm{KmcSHMTcTHF}}+\frac{\mathrm{cser}}{\mathrm{KmcSHMTcser}}\frac{\mathrm{cTHF}}{\mathrm{KmcSHMTcTHF}}}-\frac{\mathrm{VmrcSHMT}\frac{\mathrm{cgly}}{\mathrm{KmcSHMTcgly}}\frac{\mathrm{cCH2THF}}{\mathrm{KmcSHMTcCH2THF}}}{1+\frac{\mathrm{cgly}}{\mathrm{KmcSHMTcgly}}+\frac{\mathrm{cCH2THF}}{\mathrm{KmcSHMTcCH2THF}}+\frac{\mathrm{cgly}}{\mathrm{KmcSHMTcgly}}\frac{\mathrm{cCH2THF}}{\mathrm{KmcSHMTcCH2THF}}}$ $\frac{\mathrm{VmcDHFR}\frac{\mathrm{cDHF}}{\mathrm{KmcDHFRcDHF}}\frac{\mathrm{cNADPH}}{\mathrm{KmcDHFRcNADPH}}}{1+\frac{\mathrm{cDHF}}{\mathrm{KmcDHFRcDHF}}+\frac{\mathrm{cNADPH}}{\mathrm{KmcDHFRcNADPH}}+\frac{\mathrm{cDHF}}{\mathrm{KmcDHFRcDHF}}\frac{\mathrm{cNADPH}}{\mathrm{KmcDHFRcNADPH}}}$ $\frac{\mathrm{Vmmeth}\mathrm{SAM}}{\mathrm{KmmethSAM}(1+\frac{\mathrm{SAH}}{\mathrm{KmmethSAH}})+\mathrm{SAM}}$ $\frac{\mathrm{VmcFTS}\frac{\mathrm{cTHF}}{\mathrm{KmcFTScTHF}}\frac{\mathrm{cHCOOH}}{\mathrm{KmcFTScHCOOH}}}{1+\frac{\mathrm{cTHF}}{\mathrm{KmcFTScTHF}}+\frac{\mathrm{cHCOOH}}{\mathrm{KmcFTScHCOOH}}+\frac{\mathrm{cTHF}}{\mathrm{KmcFTScTHF}}\frac{\mathrm{cHCOOH}}{\mathrm{KmcFTScHCOOH}}}$ $\frac{\mathrm{VmcFTD}\frac{\mathrm{c10fTHF}}{\mathrm{kmcFTDc10fTHF}}}{1+\frac{\mathrm{c10fTHF}}{\mathrm{kmcFTDc10fTHF}}}$ $\frac{\mathrm{VmcPGT}\frac{\mathrm{c10fTHF}}{\mathrm{KmcPGTc10fTHF}}\frac{\mathrm{GARP}}{\mathrm{KmcPGTGARP}}}{1+\frac{\mathrm{c10fTHF}}{\mathrm{KmcPGTc10fTHF}}+\frac{\mathrm{GARP}}{\mathrm{KmcPGTGARP}}+\frac{\mathrm{c10fTHF}}{\mathrm{KmcPGTc10fTHF}}\frac{\mathrm{GARP}}{\mathrm{KmcPGTGARP}}}$ $\frac{\mathrm{VmcART}\frac{\mathrm{c10fTHF}}{\mathrm{KmcARTc10fTHF}}\frac{\mathrm{aic}}{\mathrm{KmcARTaic}}}{1+\frac{\mathrm{c10fTHF}}{\mathrm{KmcARTc10fTHF}}+\frac{\mathrm{aic}}{\mathrm{KmcARTaic}}+\frac{\mathrm{c10fTHF}}{\mathrm{KmcARTc10fTHF}}\frac{\mathrm{aic}}{\mathrm{KmcARTaic}}}$ $\mathrm{kfcNE}\mathrm{cTHF}\mathrm{HCHO}-\mathrm{krcNE}\mathrm{cCH2THF}$ $\frac{\mathrm{VmfcMTCH}\frac{\mathrm{cCHTHF}}{\mathrm{KmcMTCHcCHTHF}}}{1+\frac{\mathrm{cCHTHF}}{\mathrm{KmcMTCHcCHTHF}}}-\frac{\mathrm{VmrcMTCH}\frac{\mathrm{c10fTHF}}{\mathrm{KmcMTCHc10fTHF}}}{1+\frac{\mathrm{c10fTHF}}{\mathrm{KmcMTCHc10fTHF}}}$ $\frac{\mathrm{VmcTS}\frac{\mathrm{DUMP}}{\mathrm{KmcTSDUMP}}\frac{\mathrm{cCH2THF}}{\mathrm{KmcTScCH2THF}}}{1+\frac{\mathrm{DUMP}}{\mathrm{KmcTSDUMP}}+\frac{\mathrm{cCH2THF}}{\mathrm{KmcTScCH2THF}}+\frac{\mathrm{DUMP}}{\mathrm{KmcTSDUMP}}\frac{\mathrm{cCH2THF}}{\mathrm{KmcTScCH2THF}}}$ $\frac{\mathrm{VmfcMTD}\frac{\mathrm{cCH2THF}}{\mathrm{KmcMTDcCH2THF}}}{1+\frac{\mathrm{cCH2THF}}{\mathrm{KmcMTDcCH2THF}}}-\frac{\mathrm{VmrcMTD}\frac{\mathrm{cCHTHF}}{\mathrm{KmcMTDcCHTHF}}}{1+\frac{\mathrm{cCHTHF}}{\mathrm{KmcMTDcCHTHF}}}$ $\frac{\frac{\frac{\mathrm{VmcMTHFR}\mathrm{cCH2THF}}{\mathrm{KmcMTHFRcCH2THF}}\frac{\mathrm{cNADPH}}{\mathrm{KmcMTHFRcNADPH}}}{1+\frac{\mathrm{cCH2THF}}{\mathrm{KmcMTHFRcCH2THF}}+\frac{\mathrm{cNADPH}}{\mathrm{KmcMTHFRcNADPH}}+\frac{\mathrm{cCH2THF}}{\mathrm{KmcMTHFRcCH2THF}}\frac{\mathrm{cNADPH}}{\mathrm{KmcMTHFRcNADPH}}}\times 63.72}{10+\begin{cases}0 & \text{if $\mathrm{SAM}< \mathrm{SAH}$}\\ \mathrm{SAM}-\mathrm{SAH} & \text{otherwise}\end{cases}}$ $\frac{\mathrm{VmfmSHMT}\frac{\mathrm{mser}}{\mathrm{KmmSHMTmser}}\frac{\mathrm{mTHF}}{\mathrm{KmmSHMTmTHF}}}{1+\frac{\mathrm{mser}}{\mathrm{KmmSHMTmser}}+\frac{\mathrm{mTHF}}{\mathrm{KmmSHMTmTHF}}+\frac{\mathrm{mser}}{\mathrm{KmmSHMTmser}}\frac{\mathrm{mTHF}}{\mathrm{KmmSHMTmTHF}}}-\frac{\mathrm{VmrmSHMT}\frac{\mathrm{mgly}}{\mathrm{KmmSHMTmgly}}\frac{\mathrm{mCH2THF}}{\mathrm{KmmSHMTmCH2THF}}}{1+\frac{\mathrm{mgly}}{\mathrm{KmmSHMTmgly}}+\frac{\mathrm{mCH2THF}}{\mathrm{KmmSHMTmCH2THF}}+\frac{\mathrm{mgly}}{\mathrm{KmmSHMTmgly}}\frac{\mathrm{mCH2THF}}{\mathrm{KmmSHMTmCH2THF}}}$ $\frac{\frac{260\mathrm{SAM}}{(63+\mathrm{SAM})(1+\frac{\mathrm{SAH}}{\mathrm{kmGNMTSAH}})}\mathrm{cgly}}{\mathrm{kmGNMTcgly}+\mathrm{cgly}}\frac{4.8}{0.35+\mathrm{c5mTHF}}$ $\frac{\mathrm{VmfmFTS}\frac{\mathrm{mTHF}}{\mathrm{KmmFTSmTHF}}\frac{\mathrm{mHCOOH}}{\mathrm{KmmFTSmHCOOH}}}{1+\frac{\mathrm{mTHF}}{\mathrm{KmmFTSmTHF}}+\frac{\mathrm{mHCOOH}}{\mathrm{KmmFTSmHCOOH}}+\frac{\mathrm{mTHF}}{\mathrm{KmmFTSmTHF}}\frac{\mathrm{mHCOOH}}{\mathrm{KmmFTSmHCOOH}}}-\frac{\mathrm{VmrmFTS}\frac{\mathrm{m10fTHF}}{\mathrm{KmmFTSm10fTHF}}}{1+\frac{\mathrm{m10fTHF}}{\mathrm{KmmFTSm10fTHF}}}$ $\frac{\mathrm{VmmFTD}\frac{\mathrm{m10fTHF}}{\mathrm{kmmFTDm10fTHF}}}{1+\frac{\mathrm{m10fTHF}}{\mathrm{kmmFTDm10fTHF}}}$ $\frac{\mathrm{VmfmMTCH}\frac{\mathrm{mCHTHF}}{\mathrm{KmmMTCHmCHTHF}}}{1+\frac{\mathrm{mCHTHF}}{\mathrm{KmmMTCHmCHTHF}}}-\frac{\mathrm{VmrmMTCH}\frac{\mathrm{m10fTHF}}{\mathrm{KmmMTCHm10fTHF}}}{1+\frac{\mathrm{m10fTHF}}{\mathrm{KmmMTCHm10fTHF}}}$ $\frac{\mathrm{VmfmMTD}\frac{\mathrm{mCH2THF}}{\mathrm{KmmMTDmCH2THF}}}{1+\frac{\mathrm{mCH2THF}}{\mathrm{KmmMTDmCH2THF}}}-\frac{\mathrm{VmrmMTD}\frac{\mathrm{mCHTHF}}{\mathrm{KmmMTDmCHTHF}}}{1+\frac{\mathrm{mCHTHF}}{\mathrm{KmmMTDmCHTHF}}}$ $\frac{\mathrm{VmmGDC}\frac{\mathrm{mgly}}{\mathrm{KmmGDCmgly}}\frac{\mathrm{mTHF}}{\mathrm{KmmGDCmTHF}}}{1+\frac{\mathrm{mgly}}{\mathrm{KmmGDCmgly}}+\frac{\mathrm{mTHF}}{\mathrm{KmmGDCmTHF}}+\frac{\mathrm{mgly}}{\mathrm{KmmGDCmgly}}\frac{\mathrm{mTHF}}{\mathrm{KmmGDCmTHF}}}$ $\frac{\mathrm{VmmSDH}\frac{\mathrm{msarc}}{\mathrm{KmmSDHsarc}}\frac{\mathrm{mTHF}}{\mathrm{KmmSDHmTHF}}}{1+\frac{\mathrm{msarc}}{\mathrm{KmmSDHsarc}}+\frac{\mathrm{mTHF}}{\mathrm{KmmSDHmTHF}}+\frac{\mathrm{msarc}}{\mathrm{KmmSDHsarc}}\frac{\mathrm{mTHF}}{\mathrm{KmmSDHmTHF}}}$ $\frac{\mathrm{VmmDMGD}\frac{\mathrm{dmg}}{\mathrm{KmmDMGDdmg}}\frac{\mathrm{mTHF}}{\mathrm{KmmDMGDmTHF}}}{1+\frac{\mathrm{dmg}}{\mathrm{KmmDMGDdmg}}+\frac{\mathrm{mTHF}}{\mathrm{KmmDMGDmTHF}}+\frac{\mathrm{dmg}}{\mathrm{KmmDMGDdmg}}\frac{\mathrm{mTHF}}{\mathrm{KmmDMGDmTHF}}}$ $\mathrm{kfmNE}\mathrm{mTHF}\mathrm{HCHO}-\mathrm{krmNE}\mathrm{mCH2THF}$ $\frac{\mathrm{vmmetin}\mathrm{bmet}}{\mathrm{kmmetinoutmethionine}+\mathrm{bmet}}-\mathrm{kmetincmethionine}\mathrm{met}$ $\mathrm{vocysb}+\mathrm{k0}\mathrm{bGSSG}\mathrm{bGSH}$ $\frac{\mathrm{Vmfah}\frac{\mathrm{SAH}}{\mathrm{KmahSAH}}}{1+\frac{\mathrm{SAH}}{\mathrm{KmahSAH}}}-\frac{1\times 6\mathrm{Vmrah}\frac{\mathrm{hcy}}{\mathrm{Kmahhcy}}}{1+\frac{\mathrm{hcy}}{\mathrm{Kmahhcy}}}$ $\mathrm{voglub}+\mathrm{k0}\mathrm{bGSSG}\mathrm{bGSH}$ $\mathrm{voglyb}+\mathrm{k0}\mathrm{bGSSG}\mathrm{bGSH}$ $1.2\mathrm{cser}$ $0.07\mathrm{cglut}$ $90\mathrm{bGSH}$ $\frac{135}{2}\mathrm{bGSSG}$ $0.1\mathrm{bgly}$ $0.35\mathrm{bcys}$ $0.1\mathrm{bglut}$ $0.7\mathrm{bGSH}$ $\frac{\frac{\frac{\mathrm{Vmbhmt}\frac{\mathrm{hcy}}{\mathrm{Kmbhmthcy}}}{1+\frac{\mathrm{hcy}}{\mathrm{Kmbhmthcy}}}\mathrm{BET}}{\mathrm{Kmbhmtbet}+\mathrm{BET}}e^{-0.0021(\mathrm{SAH}+\mathrm{SAM})}e^{0.0021\times 102.59}(\mathrm{H2O2ss}+\mathrm{KibhmtH2O2})}{\mathrm{H2O2}+\mathrm{KibhmtH2O2}}$ $7.5\mathrm{bGSSG}$ $\frac{\frac{\frac{\mathrm{vmMS}\frac{\mathrm{hcy}}{\mathrm{kmMShcy}}}{1+\frac{\mathrm{hcy}}{\mathrm{kmMShcy}}}\frac{\mathrm{c5mTHF}}{\mathrm{kmMSmTH4}}}{1+\frac{\mathrm{c5mTHF}}{\mathrm{kmMSmTH4}}}(\mathrm{kiMSH2O2}+\mathrm{H2O2ss})}{\mathrm{kiMSH2O2}+\mathrm{H2O2}}$ $\frac{\frac{\frac{\frac{\frac{\mathrm{Vmcbs}\mathrm{cser}}{\mathrm{Kmcbsserine}+\mathrm{cser}}\mathrm{hcy}}{\mathrm{Kmcbshcy}}}{1+\frac{\mathrm{hcy}}{\mathrm{Kmcbshcy}}}\times 1.2}{\left(\frac{30}{\mathrm{SAM}+\mathrm{SAH}}\right)^2+1}\left(\frac{1.2}{\left(\frac{30}{102.59}\right)^2+1}\right)^{-1}(\mathrm{kaH2O2}+\mathrm{H2O2})}{\mathrm{kaH2O2}+\mathrm{H2O2ss}}$ $\frac{\mathrm{vmctgl}\frac{\mathrm{cyt}}{\mathrm{kmctglcyt}}}{1+\frac{\mathrm{cyt}}{\mathrm{kmctglcyt}}}$