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odendaal3

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odendaal3

Model adapted from odendaal1 to simulate an in vitro experiment using cell lysate. Cytosolic compartment removed, partitioning factors set to 1, and volume and substrate concentration adjusted to the assay volume. Two Vmaxes, Vmcad and Vvlcad, contain terms allowing the user to easily set them to zero, to emulate the immunoprecipitation of those enzymes in the experiments and are therefore assignment rules and not parameters.

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Manuscript information

Personalised modelling of clinical heterogeneity between medium-chain acyl-CoA dehydrogenase patients.

  • Christoff Odendaal
  • Emmalie A Jager
  • Anne-Claire M F Martines
  • Marcel A Vieira-Lara
  • Nicolette C A Huijkman
  • Ligia A Kiyuna
  • Albert Gerding
  • Justina C Wolters
  • Rebecca Heiner-Fokkema
  • Karen van Eunen
  • Terry G J Derks
  • Barbara M Bakker
BMC Biol 2023; 21 (1): 184
Abstract
BACKGROUND: Monogenetic inborn errors of metabolism cause a wide phenotypic heterogeneity that may even differ between family members carrying the same genetic variant. Computational modelling of metabolic networks may identify putative sources of this inter-patient heterogeneity. Here, we mainly focus on medium-chain acyl-CoA dehydrogenase deficiency (MCADD), the most common inborn error of the mitochondrial fatty acid oxidation (mFAO). It is an enigma why some MCADD patients-if untreated-are at risk to develop severe metabolic decompensations, whereas others remain asymptomatic throughout life. We hypothesised that an ability to maintain an increased free mitochondrial CoA (CoASH) and pathway flux might distinguish asymptomatic from symptomatic patients.
RESULTS: We built and experimentally validated, for the first time, a kinetic model of the human liver mFAO. Metabolites were partitioned according to their water solubility between the bulk aqueous matrix and the inner membrane. Enzymes are also either membrane-bound or in the matrix. This metabolite partitioning is a novel model attribute and improved predictions. MCADD substantially reduced pathway flux and CoASH, the latter due to the sequestration of CoA as medium-chain acyl-CoA esters. Analysis of urine from MCADD patients obtained during a metabolic decompensation showed an accumulation of medium- and short-chain acylcarnitines, just like the acyl-CoA pool in the MCADD model. The model suggested some rescues that increased flux and CoASH, notably increasing short-chain acyl-CoA dehydrogenase (SCAD) levels. Proteome analysis of MCADD patient-derived fibroblasts indeed revealed elevated levels of SCAD in a patient with a clinically asymptomatic state. This is a rescue for MCADD that has not been explored before. Personalised models based on these proteomics data confirmed an increased pathway flux and CoASH in the model of an asymptomatic patient compared to those of symptomatic MCADD patients.
CONCLUSIONS: We present a detailed, validated kinetic model of mFAO in human liver, with solubility-dependent metabolite partitioning. Personalised modelling of individual patients provides a novel explanation for phenotypic heterogeneity among MCADD patients. Further development of personalised metabolic models is a promising direction to improve individualised risk assessment, management and monitoring for inborn errors of metabolism.

Unit definitions 0

Unit definitions have no effect on the numerical analysis of the model. It remains the responsibility of the modeler to ensure the internal numerical consistency of the model. If units are provided, however, the consistency of the model units will be checked.

Name Definition

Compartments 1

Id Name Spatial dimensions Size
VMAT VMAT 0.0 0.4349

Species 40

Id Name Initial quantity Compartment Fixed
C10AcylCarMAT — 0.0 VMAT (VMAT) ✔
C10AcylCoAMAT — 0.0 VMAT (VMAT) ✘
C10EnoylCoAMAT — 0.0 VMAT (VMAT) ✘
C10HydroxyacylCoAMAT — 0.0 VMAT (VMAT) ✘
C10KetoacylCoAMAT — 0.0 VMAT (VMAT) ✘
C12AcylCarMAT — 0.0 VMAT (VMAT) ✔
C12AcylCoAMAT — 0.0 VMAT (VMAT) ✘
C12EnoylCoAMAT — 0.0 VMAT (VMAT) ✘
C12HydroxyacylCoAMAT — 0.0 VMAT (VMAT) ✘
C12KetoacylCoAMAT — 0.0 VMAT (VMAT) ✘
C14AcylCarMAT — 0.0 VMAT (VMAT) ✔
C14AcylCoAMAT — 0.0 VMAT (VMAT) ✘
C14EnoylCoAMAT — 0.0 VMAT (VMAT) ✘
C14HydroxyacylCoAMAT — 0.0 VMAT (VMAT) ✘
C14KetoacylCoAMAT — 0.0 VMAT (VMAT) ✘
C16AcylCarMAT — 0.0 VMAT (VMAT) ✔
C16AcylCoAMAT — nan VMAT (VMAT) ✘
C16EnoylCoAMAT — 0.0 VMAT (VMAT) ✘
C16HydroxyacylCoAMAT — 0.0 VMAT (VMAT) ✘
C16KetoacylCoAMAT — 0.0 VMAT (VMAT) ✘
C2AcylCoAMAT — 0.0 VMAT (VMAT) ✘
C4AcylCarMAT — 0.0 VMAT (VMAT) ✔
C4AcylCoAMAT — 0.0 VMAT (VMAT) ✘
C4EnoylCoAMAT — 0.0 VMAT (VMAT) ✘
C4HydroxyacylCoAMAT — 0.0 VMAT (VMAT) ✘
C4KetoacylCoAMAT — 0.0 VMAT (VMAT) ✘
C6AcylCarMAT — 0.0 VMAT (VMAT) ✔
C6AcylCoAMAT — 0.0 VMAT (VMAT) ✘
C6EnoylCoAMAT — 0.0 VMAT (VMAT) ✘
C6HydroxyacylCoAMAT — 0.0 VMAT (VMAT) ✘
C6KetoacylCoAMAT — 0.0 VMAT (VMAT) ✘
C8AcylCarMAT — 0.0 VMAT (VMAT) ✔
C8AcylCoAMAT — nan VMAT (VMAT) ✘
C8EnoylCoAMAT — 0.0 VMAT (VMAT) ✘
C8HydroxyacylCoAMAT — 0.0 VMAT (VMAT) ✘
C8KetoacylCoAMAT — 0.0 VMAT (VMAT) ✘
NAD — 0.0011608211083 VMAT (VMAT) ✘
NADH — 0.000178567256841 VMAT (VMAT) ✘
PMSox — 1600.0 VMAT (VMAT) ✘
PMSred — 0.0 VMAT (VMAT) ✘

Initial assignments 2

Initial assignments are expressions that are evaluated at time=0. It is not recommended to create initial assignments for all model entities. Restrict the use of initial assignments to cases where a value is expressed in terms of values or sizes of other model entities. Note that it is not permitted to have both an initial assignment and an assignment rule for a single model entity.

Definition
C8AcylCoAMAT = OctCoA
C16AcylCoAMAT = PalCoA
Reactions 63
Id Name Objective coefficient Reaction Equation and Kinetic Law Flux bounds
vacotciC10 — C10AcylCoAMAT = ∅

sfacotciC10 * Vacotci * C10AcylCoAMAT / (KmacotciC10AcylCoAMAT * pfC10AcylCoA * (1 + C10AcylCoAMAT / (KmacotciC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotciC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotciC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotciC16AcylCoAMAT * pfC16AcylCoA)))
vacotciC12 — C12AcylCoAMAT = ∅

sfacotciC12 * Vacotci * C12AcylCoAMAT / (KmacotciC12AcylCoAMAT * pfC12AcylCoA * (1 + C10AcylCoAMAT / (KmacotciC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotciC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotciC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotciC16AcylCoAMAT * pfC16AcylCoA)))
vacotciC14 — C14AcylCoAMAT = ∅

sfacotciC14 * Vacotci * C14AcylCoAMAT / (KmacotciC14AcylCoAMAT * pfC14AcylCoA * (1 + C10AcylCoAMAT / (KmacotciC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotciC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotciC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotciC16AcylCoAMAT * pfC16AcylCoA)))
vacotciC16 — C16AcylCoAMAT = ∅

sfacotciC16 * Vacotci * C16AcylCoAMAT / (KmacotciC16AcylCoAMAT * pfC16AcylCoA * (1 + C10AcylCoAMAT / (KmacotciC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotciC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotciC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotciC16AcylCoAMAT * pfC16AcylCoA)))
vacotcsC10 — C10AcylCoAMAT = ∅

sfacotcsC10 * Vacotcs * C10AcylCoAMAT / (KmacotcsC10AcylCoAMAT * pfC10AcylCoA * (1 + C10AcylCoAMAT / (KmacotcsC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotcsC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotcsC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotcsC16AcylCoAMAT * pfC16AcylCoA) + C4AcylCoAMAT / (KmacotcsC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCoAMAT / (KmacotcsC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCoAMAT / (KmacotcsC8AcylCoAMAT * pfC8AcylCoA) + CoAMAT / KiacotcsCoAMAT))
vacotcsC12 — C12AcylCoAMAT = ∅

sfacotcsC12 * Vacotcs * C12AcylCoAMAT / (KmacotcsC12AcylCoAMAT * pfC12AcylCoA * (1 + C10AcylCoAMAT / (KmacotcsC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotcsC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotcsC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotcsC16AcylCoAMAT * pfC16AcylCoA) + C4AcylCoAMAT / (KmacotcsC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCoAMAT / (KmacotcsC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCoAMAT / (KmacotcsC8AcylCoAMAT * pfC8AcylCoA) + CoAMAT / KiacotcsCoAMAT))
vacotcsC14 — C14AcylCoAMAT = ∅

sfacotcsC14 * Vacotcs * C14AcylCoAMAT / (KmacotcsC14AcylCoAMAT * pfC14AcylCoA * (1 + C10AcylCoAMAT / (KmacotcsC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotcsC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotcsC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotcsC16AcylCoAMAT * pfC16AcylCoA) + C4AcylCoAMAT / (KmacotcsC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCoAMAT / (KmacotcsC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCoAMAT / (KmacotcsC8AcylCoAMAT * pfC8AcylCoA) + CoAMAT / KiacotcsCoAMAT))
vacotcsC16 — C16AcylCoAMAT = ∅

sfacotcsC16 * Vacotcs * C16AcylCoAMAT / (KmacotcsC16AcylCoAMAT * pfC16AcylCoA * (1 + C10AcylCoAMAT / (KmacotcsC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotcsC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotcsC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotcsC16AcylCoAMAT * pfC16AcylCoA) + C4AcylCoAMAT / (KmacotcsC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCoAMAT / (KmacotcsC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCoAMAT / (KmacotcsC8AcylCoAMAT * pfC8AcylCoA) + CoAMAT / KiacotcsCoAMAT))
vacotcsC4 — C4AcylCoAMAT = ∅

sfacotcsC4 * Vacotcs * C4AcylCoAMAT / (KmacotcsC4AcylCoAMAT * pfC4AcylCoA * (1 + C10AcylCoAMAT / (KmacotcsC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotcsC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotcsC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotcsC16AcylCoAMAT * pfC16AcylCoA) + C4AcylCoAMAT / (KmacotcsC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCoAMAT / (KmacotcsC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCoAMAT / (KmacotcsC8AcylCoAMAT * pfC8AcylCoA) + CoAMAT / KiacotcsCoAMAT))
vacotcsC6 — C6AcylCoAMAT = ∅

sfacotcsC6 * Vacotcs * C6AcylCoAMAT / (KmacotcsC6AcylCoAMAT * pfC6AcylCoA * (1 + C10AcylCoAMAT / (KmacotcsC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotcsC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotcsC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotcsC16AcylCoAMAT * pfC16AcylCoA) + C4AcylCoAMAT / (KmacotcsC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCoAMAT / (KmacotcsC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCoAMAT / (KmacotcsC8AcylCoAMAT * pfC8AcylCoA) + CoAMAT / KiacotcsCoAMAT))
vacotcsC8 — C8AcylCoAMAT = ∅

sfacotcsC8 * Vacotcs * C8AcylCoAMAT / (KmacotcsC8AcylCoAMAT * pfC8AcylCoA * (1 + C10AcylCoAMAT / (KmacotcsC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (KmacotcsC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (KmacotcsC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (KmacotcsC16AcylCoAMAT * pfC16AcylCoA) + C4AcylCoAMAT / (KmacotcsC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCoAMAT / (KmacotcsC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCoAMAT / (KmacotcsC8AcylCoAMAT * pfC8AcylCoA) + CoAMAT / KiacotcsCoAMAT))
vcpt2C10 — ∅ = C10AcylCoAMAT

contactSiteCPT * sfcpt2C10 * Vcpt2 * (-(pfC10AcylCoA * C10AcylCoAMAT * CarMAT / (Keqcpt2C10 * Kmcpt2C10AcylCarMAT * Kmcpt2CoAMAT)) + pfC10AcylCar * C10AcylCarMAT * CoAMAT / (Kmcpt2C10AcylCarMAT * Kmcpt2CoAMAT)) / ((1 + pfC10AcylCar * C10AcylCarMAT / Kmcpt2C10AcylCarMAT + pfC10AcylCoA * C10AcylCoAMAT / Kmcpt2C10AcylCoAMAT + pfC12AcylCar * C12AcylCarMAT / Kmcpt2C12AcylCarMAT + pfC12AcylCoA * C12AcylCoAMAT / Kmcpt2C12AcylCoAMAT + pfC14AcylCar * C14AcylCarMAT / Kmcpt2C14AcylCarMAT + pfC14AcylCoA * C14AcylCoAMAT / Kmcpt2C14AcylCoAMAT + pfC16AcylCar * C16AcylCarMAT / Kmcpt2C16AcylCarMAT + pfC16AcylCoA * C16AcylCoAMAT / Kmcpt2C16AcylCoAMAT + pfC4AcylCar * C4AcylCarMAT / Kmcpt2C4AcylCarMAT + pfC4AcylCoA * C4AcylCoAMAT / Kmcpt2C4AcylCoAMAT + pfC6AcylCar * C6AcylCarMAT / Kmcpt2C6AcylCarMAT + pfC6AcylCoA * C6AcylCoAMAT / Kmcpt2C6AcylCoAMAT + pfC8AcylCar * C8AcylCarMAT / Kmcpt2C8AcylCarMAT + pfC8AcylCoA * C8AcylCoAMAT / Kmcpt2C8AcylCoAMAT) * (1 + CarMAT / Kicpt2CarMAT + CoAMAT / Kmcpt2CoAMAT))
vcpt2C12 — ∅ = C12AcylCoAMAT

contactSiteCPT * sfcpt2C12 * Vcpt2 * (-(pfC12AcylCoA * C12AcylCoAMAT * CarMAT / (Keqcpt2C12 * Kmcpt2C12AcylCarMAT * Kmcpt2CoAMAT)) + pfC12AcylCar * C12AcylCarMAT * CoAMAT / (Kmcpt2C12AcylCarMAT * Kmcpt2CoAMAT)) / ((1 + pfC10AcylCar * C10AcylCarMAT / Kmcpt2C10AcylCarMAT + pfC10AcylCoA * C10AcylCoAMAT / Kmcpt2C10AcylCoAMAT + pfC12AcylCar * C12AcylCarMAT / Kmcpt2C12AcylCarMAT + pfC12AcylCoA * C12AcylCoAMAT / Kmcpt2C12AcylCoAMAT + pfC14AcylCar * C14AcylCarMAT / Kmcpt2C14AcylCarMAT + pfC14AcylCoA * C14AcylCoAMAT / Kmcpt2C14AcylCoAMAT + pfC16AcylCar * C16AcylCarMAT / Kmcpt2C16AcylCarMAT + pfC16AcylCoA * C16AcylCoAMAT / Kmcpt2C16AcylCoAMAT + pfC4AcylCar * C4AcylCarMAT / Kmcpt2C4AcylCarMAT + pfC4AcylCoA * C4AcylCoAMAT / Kmcpt2C4AcylCoAMAT + pfC6AcylCar * C6AcylCarMAT / Kmcpt2C6AcylCarMAT + pfC6AcylCoA * C6AcylCoAMAT / Kmcpt2C6AcylCoAMAT + pfC8AcylCar * C8AcylCarMAT / Kmcpt2C8AcylCarMAT + pfC8AcylCoA * C8AcylCoAMAT / Kmcpt2C8AcylCoAMAT) * (1 + CarMAT / Kicpt2CarMAT + CoAMAT / Kmcpt2CoAMAT))
vcpt2C14 — ∅ = C14AcylCoAMAT

contactSiteCPT * sfcpt2C14 * Vcpt2 * (-(pfC14AcylCoA * C14AcylCoAMAT * CarMAT / (Keqcpt2C14 * Kmcpt2C14AcylCarMAT * Kmcpt2CoAMAT)) + pfC14AcylCar * C14AcylCarMAT * CoAMAT / (Kmcpt2C14AcylCarMAT * Kmcpt2CoAMAT)) / ((1 + pfC10AcylCar * C10AcylCarMAT / Kmcpt2C10AcylCarMAT + pfC10AcylCoA * C10AcylCoAMAT / Kmcpt2C10AcylCoAMAT + pfC12AcylCar * C12AcylCarMAT / Kmcpt2C12AcylCarMAT + pfC12AcylCoA * C12AcylCoAMAT / Kmcpt2C12AcylCoAMAT + pfC14AcylCar * C14AcylCarMAT / Kmcpt2C14AcylCarMAT + pfC14AcylCoA * C14AcylCoAMAT / Kmcpt2C14AcylCoAMAT + pfC16AcylCar * C16AcylCarMAT / Kmcpt2C16AcylCarMAT + pfC16AcylCoA * C16AcylCoAMAT / Kmcpt2C16AcylCoAMAT + pfC4AcylCar * C4AcylCarMAT / Kmcpt2C4AcylCarMAT + pfC4AcylCoA * C4AcylCoAMAT / Kmcpt2C4AcylCoAMAT + pfC6AcylCar * C6AcylCarMAT / Kmcpt2C6AcylCarMAT + pfC6AcylCoA * C6AcylCoAMAT / Kmcpt2C6AcylCoAMAT + pfC8AcylCar * C8AcylCarMAT / Kmcpt2C8AcylCarMAT + pfC8AcylCoA * C8AcylCoAMAT / Kmcpt2C8AcylCoAMAT) * (1 + CarMAT / Kicpt2CarMAT + CoAMAT / Kmcpt2CoAMAT))
vcpt2C16 — ∅ = C16AcylCoAMAT

contactSiteCPT * sfcpt2C16 * Vcpt2 * (-(pfC16AcylCoA * C16AcylCoAMAT * CarMAT / (Keqcpt2C16 * Kmcpt2C16AcylCarMAT * Kmcpt2CoAMAT)) + pfC16AcylCar * C16AcylCarMAT * CoAMAT / (Kmcpt2C16AcylCarMAT * Kmcpt2CoAMAT)) / ((1 + pfC10AcylCar * C10AcylCarMAT / Kmcpt2C10AcylCarMAT + pfC10AcylCoA * C10AcylCoAMAT / Kmcpt2C10AcylCoAMAT + pfC12AcylCar * C12AcylCarMAT / Kmcpt2C12AcylCarMAT + pfC12AcylCoA * C12AcylCoAMAT / Kmcpt2C12AcylCoAMAT + pfC14AcylCar * C14AcylCarMAT / Kmcpt2C14AcylCarMAT + pfC14AcylCoA * C14AcylCoAMAT / Kmcpt2C14AcylCoAMAT + pfC16AcylCar * C16AcylCarMAT / Kmcpt2C16AcylCarMAT + pfC16AcylCoA * C16AcylCoAMAT / Kmcpt2C16AcylCoAMAT + pfC4AcylCar * C4AcylCarMAT / Kmcpt2C4AcylCarMAT + pfC4AcylCoA * C4AcylCoAMAT / Kmcpt2C4AcylCoAMAT + pfC6AcylCar * C6AcylCarMAT / Kmcpt2C6AcylCarMAT + pfC6AcylCoA * C6AcylCoAMAT / Kmcpt2C6AcylCoAMAT + pfC8AcylCar * C8AcylCarMAT / Kmcpt2C8AcylCarMAT + pfC8AcylCoA * C8AcylCoAMAT / Kmcpt2C8AcylCoAMAT) * (1 + CarMAT / Kicpt2CarMAT + CoAMAT / Kmcpt2CoAMAT))
vcpt2C4 — ∅ = C4AcylCoAMAT

contactSiteCPT * sfcpt2C4 * Vcpt2 * (-(pfC4AcylCoA * C4AcylCoAMAT * CarMAT / (Keqcpt2C4 * Kmcpt2C4AcylCarMAT * Kmcpt2CoAMAT)) + pfC4AcylCar * C4AcylCarMAT * CoAMAT / (Kmcpt2C4AcylCarMAT * Kmcpt2CoAMAT)) / ((1 + pfC10AcylCar * C10AcylCarMAT / Kmcpt2C10AcylCarMAT + pfC10AcylCoA * C10AcylCoAMAT / Kmcpt2C10AcylCoAMAT + pfC12AcylCar * C12AcylCarMAT / Kmcpt2C12AcylCarMAT + pfC12AcylCoA * C12AcylCoAMAT / Kmcpt2C12AcylCoAMAT + pfC14AcylCar * C14AcylCarMAT / Kmcpt2C14AcylCarMAT + pfC14AcylCoA * C14AcylCoAMAT / Kmcpt2C14AcylCoAMAT + pfC16AcylCar * C16AcylCarMAT / Kmcpt2C16AcylCarMAT + pfC16AcylCoA * C16AcylCoAMAT / Kmcpt2C16AcylCoAMAT + pfC4AcylCar * C4AcylCarMAT / Kmcpt2C4AcylCarMAT + pfC4AcylCoA * C4AcylCoAMAT / Kmcpt2C4AcylCoAMAT + pfC6AcylCar * C6AcylCarMAT / Kmcpt2C6AcylCarMAT + pfC6AcylCoA * C6AcylCoAMAT / Kmcpt2C6AcylCoAMAT + pfC8AcylCar * C8AcylCarMAT / Kmcpt2C8AcylCarMAT + pfC8AcylCoA * C8AcylCoAMAT / Kmcpt2C8AcylCoAMAT) * (1 + CarMAT / Kicpt2CarMAT + CoAMAT / Kmcpt2CoAMAT))
vcpt2C6 — ∅ = C6AcylCoAMAT

contactSiteCPT * sfcpt2C6 * Vcpt2 * (-(pfC6AcylCoA * C6AcylCoAMAT * CarMAT / (Keqcpt2C6 * Kmcpt2C6AcylCarMAT * Kmcpt2CoAMAT)) + pfC6AcylCar * C6AcylCarMAT * CoAMAT / (Kmcpt2C6AcylCarMAT * Kmcpt2CoAMAT)) / ((1 + pfC10AcylCar * C10AcylCarMAT / Kmcpt2C10AcylCarMAT + pfC10AcylCoA * C10AcylCoAMAT / Kmcpt2C10AcylCoAMAT + pfC12AcylCar * C12AcylCarMAT / Kmcpt2C12AcylCarMAT + pfC12AcylCoA * C12AcylCoAMAT / Kmcpt2C12AcylCoAMAT + pfC14AcylCar * C14AcylCarMAT / Kmcpt2C14AcylCarMAT + pfC14AcylCoA * C14AcylCoAMAT / Kmcpt2C14AcylCoAMAT + pfC16AcylCar * C16AcylCarMAT / Kmcpt2C16AcylCarMAT + pfC16AcylCoA * C16AcylCoAMAT / Kmcpt2C16AcylCoAMAT + pfC4AcylCar * C4AcylCarMAT / Kmcpt2C4AcylCarMAT + pfC4AcylCoA * C4AcylCoAMAT / Kmcpt2C4AcylCoAMAT + pfC6AcylCar * C6AcylCarMAT / Kmcpt2C6AcylCarMAT + pfC6AcylCoA * C6AcylCoAMAT / Kmcpt2C6AcylCoAMAT + pfC8AcylCar * C8AcylCarMAT / Kmcpt2C8AcylCarMAT + pfC8AcylCoA * C8AcylCoAMAT / Kmcpt2C8AcylCoAMAT) * (1 + CarMAT / Kicpt2CarMAT + CoAMAT / Kmcpt2CoAMAT))
vcpt2C8 — ∅ = C8AcylCoAMAT

contactSiteCPT * sfcpt2C8 * Vcpt2 * (-(pfC8AcylCoA * C8AcylCoAMAT * CarMAT / (Keqcpt2C8 * Kmcpt2C8AcylCarMAT * Kmcpt2CoAMAT)) + pfC8AcylCar * C8AcylCarMAT * CoAMAT / (Kmcpt2C8AcylCarMAT * Kmcpt2CoAMAT)) / ((1 + pfC10AcylCar * C10AcylCarMAT / Kmcpt2C10AcylCarMAT + pfC10AcylCoA * C10AcylCoAMAT / Kmcpt2C10AcylCoAMAT + pfC12AcylCar * C12AcylCarMAT / Kmcpt2C12AcylCarMAT + pfC12AcylCoA * C12AcylCoAMAT / Kmcpt2C12AcylCoAMAT + pfC14AcylCar * C14AcylCarMAT / Kmcpt2C14AcylCarMAT + pfC14AcylCoA * C14AcylCoAMAT / Kmcpt2C14AcylCoAMAT + pfC16AcylCar * C16AcylCarMAT / Kmcpt2C16AcylCarMAT + pfC16AcylCoA * C16AcylCoAMAT / Kmcpt2C16AcylCoAMAT + pfC4AcylCar * C4AcylCarMAT / Kmcpt2C4AcylCarMAT + pfC4AcylCoA * C4AcylCoAMAT / Kmcpt2C4AcylCoAMAT + pfC6AcylCar * C6AcylCarMAT / Kmcpt2C6AcylCarMAT + pfC6AcylCoA * C6AcylCoAMAT / Kmcpt2C6AcylCoAMAT + pfC8AcylCar * C8AcylCarMAT / Kmcpt2C8AcylCarMAT + pfC8AcylCoA * C8AcylCoAMAT / Kmcpt2C8AcylCoAMAT) * (1 + CarMAT / Kicpt2CarMAT + CoAMAT / Kmcpt2CoAMAT))
vcratC10 — C10AcylCoAMAT = ∅

sfcratC10 * Vcrat * (C10AcylCoAMAT * CarMAT / (KmcratC10AcylCoAMAT * KmcratCarMAT * pfC10AcylCoA) - C10AcylCarMAT * CoAMAT / (KeqcratC10 * KmcratC10AcylCoAMAT * KmcratCarMAT * pfC10AcylCar)) / ((1 + C2AcylCarMAT / (KmcratC2AcylCarMAT * pfC2AcylCar) + C10AcylCarMAT / (KmcratC10AcylCarMAT * pfC10AcylCar) + C10AcylCoAMAT / (KmcratC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (Ki1cratC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (Ki1cratC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (Ki1cratC16AcylCoAMAT * pfC16AcylCoA) + C2AcylCoAMAT / (KmcratC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCarMAT / (KmcratC4AcylCarMAT * pfC4AcylCar) + C4AcylCoAMAT / (KmcratC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCarMAT / (KmcratC6AcylCarMAT * pfC6AcylCar) + C6AcylCoAMAT / (KmcratC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCarMAT / (KmcratC8AcylCarMAT * pfC8AcylCar) + C8AcylCoAMAT / (KmcratC8AcylCoAMAT * pfC8AcylCoA)) * (1 + C10AcylCoAMAT / (Ki2cratC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (Ki2cratC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (Ki2cratC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (Ki2cratC16AcylCoAMAT * pfC16AcylCoA) + CarMAT / KmcratCarMAT + CoAMAT / KmcratCoAMAT))
vcratC4 — C4AcylCoAMAT = ∅

sfcratC4 * Vcrat * (C4AcylCoAMAT * CarMAT / (KmcratC4AcylCoAMAT * KmcratCarMAT * pfC4AcylCoA) - C4AcylCarMAT * CoAMAT / (KeqcratC4 * KmcratC4AcylCoAMAT * KmcratCarMAT * pfC4AcylCar)) / ((1 + C2AcylCarMAT / (KmcratC2AcylCarMAT * pfC2AcylCar) + C10AcylCarMAT / (KmcratC10AcylCarMAT * pfC10AcylCar) + C10AcylCoAMAT / (KmcratC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (Ki1cratC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (Ki1cratC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (Ki1cratC16AcylCoAMAT * pfC16AcylCoA) + C2AcylCoAMAT / (KmcratC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCarMAT / (KmcratC4AcylCarMAT * pfC4AcylCar) + C4AcylCoAMAT / (KmcratC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCarMAT / (KmcratC6AcylCarMAT * pfC6AcylCar) + C6AcylCoAMAT / (KmcratC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCarMAT / (KmcratC8AcylCarMAT * pfC8AcylCar) + C8AcylCoAMAT / (KmcratC8AcylCoAMAT * pfC8AcylCoA)) * (1 + C10AcylCoAMAT / (Ki2cratC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (Ki2cratC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (Ki2cratC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (Ki2cratC16AcylCoAMAT * pfC16AcylCoA) + CarMAT / KmcratCarMAT + CoAMAT / KmcratCoAMAT))
vcratC6 — C6AcylCoAMAT = ∅

sfcratC6 * Vcrat * (C6AcylCoAMAT * CarMAT / (KmcratC6AcylCoAMAT * KmcratCarMAT * pfC6AcylCoA) - C6AcylCarMAT * CoAMAT / (KeqcratC6 * KmcratC6AcylCoAMAT * KmcratCarMAT * pfC6AcylCar)) / ((1 + C2AcylCarMAT / (KmcratC2AcylCarMAT * pfC2AcylCar) + C10AcylCarMAT / (KmcratC10AcylCarMAT * pfC10AcylCar) + C10AcylCoAMAT / (KmcratC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (Ki1cratC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (Ki1cratC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (Ki1cratC16AcylCoAMAT * pfC16AcylCoA) + C2AcylCoAMAT / (KmcratC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCarMAT / (KmcratC4AcylCarMAT * pfC4AcylCar) + C4AcylCoAMAT / (KmcratC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCarMAT / (KmcratC6AcylCarMAT * pfC6AcylCar) + C6AcylCoAMAT / (KmcratC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCarMAT / (KmcratC8AcylCarMAT * pfC8AcylCar) + C8AcylCoAMAT / (KmcratC8AcylCoAMAT * pfC8AcylCoA)) * (1 + C10AcylCoAMAT / (Ki2cratC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (Ki2cratC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (Ki2cratC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (Ki2cratC16AcylCoAMAT * pfC16AcylCoA) + CarMAT / KmcratCarMAT + CoAMAT / KmcratCoAMAT))
vcratC8 — C8AcylCoAMAT = ∅

sfcratC8 * Vcrat * (C8AcylCoAMAT * CarMAT / (KmcratC8AcylCoAMAT * KmcratCarMAT * pfC8AcylCoA) - C8AcylCarMAT * CoAMAT / (KeqcratC8 * KmcratC8AcylCoAMAT * KmcratCarMAT * pfC8AcylCar)) / ((1 + C2AcylCarMAT / (KmcratC2AcylCarMAT * pfC2AcylCar) + C10AcylCarMAT / (KmcratC10AcylCarMAT * pfC10AcylCar) + C10AcylCoAMAT / (KmcratC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (Ki1cratC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (Ki1cratC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (Ki1cratC16AcylCoAMAT * pfC16AcylCoA) + C2AcylCoAMAT / (KmcratC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCarMAT / (KmcratC4AcylCarMAT * pfC4AcylCar) + C4AcylCoAMAT / (KmcratC4AcylCoAMAT * pfC4AcylCoA) + C6AcylCarMAT / (KmcratC6AcylCarMAT * pfC6AcylCar) + C6AcylCoAMAT / (KmcratC6AcylCoAMAT * pfC6AcylCoA) + C8AcylCarMAT / (KmcratC8AcylCarMAT * pfC8AcylCar) + C8AcylCoAMAT / (KmcratC8AcylCoAMAT * pfC8AcylCoA)) * (1 + C10AcylCoAMAT / (Ki2cratC10AcylCoAMAT * pfC10AcylCoA) + C12AcylCoAMAT / (Ki2cratC12AcylCoAMAT * pfC12AcylCoA) + C14AcylCoAMAT / (Ki2cratC14AcylCoAMAT * pfC14AcylCoA) + C16AcylCoAMAT / (Ki2cratC16AcylCoAMAT * pfC16AcylCoA) + CarMAT / KmcratCarMAT + CoAMAT / KmcratCoAMAT))
vcrotC10 — C10EnoylCoAMAT = C10HydroxyacylCoAMAT

sfcrotC10 * Vcrot * (C10EnoylCoAMAT / (KmcrotC10EnoylCoAMAT * pfC10EnoylCoA) - C10HydroxyacylCoAMAT / (KeqcrotC10 * KmcrotC10EnoylCoAMAT * pfC10HydroxyacylCoA)) / (1 + C10EnoylCoAMAT / (KmcrotC10EnoylCoAMAT * pfC10EnoylCoA) + C10HydroxyacylCoAMAT / (KmcrotC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C12EnoylCoAMAT / (KmcrotC12EnoylCoAMAT * pfC12EnoylCoA) + C12HydroxyacylCoAMAT / (KmcrotC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C14EnoylCoAMAT / (KmcrotC14EnoylCoAMAT * pfC14EnoylCoA) + C14HydroxyacylCoAMAT / (KmcrotC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C16EnoylCoAMAT / (KmcrotC16EnoylCoAMAT * pfC16EnoylCoA) + C16HydroxyacylCoAMAT / (KmcrotC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C4EnoylCoAMAT / (KmcrotC4EnoylCoAMAT * pfC4EnoylCoA) + C4HydroxyacylCoAMAT / (KmcrotC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KicrotC4KetoacylCoA * pfC4KetoacylCoA) + C6EnoylCoAMAT / (KmcrotC6EnoylCoAMAT * pfC6EnoylCoA) + C6HydroxyacylCoAMAT / (KmcrotC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C8EnoylCoAMAT / (KmcrotC8EnoylCoAMAT * pfC8EnoylCoA) + C8HydroxyacylCoAMAT / (KmcrotC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA))
vcrotC12 — C12EnoylCoAMAT = C12HydroxyacylCoAMAT

sfcrotC12 * Vcrot * (C12EnoylCoAMAT / (KmcrotC12EnoylCoAMAT * pfC12EnoylCoA) - C12HydroxyacylCoAMAT / (KeqcrotC12 * KmcrotC12EnoylCoAMAT * pfC12HydroxyacylCoA)) / (1 + C10EnoylCoAMAT / (KmcrotC10EnoylCoAMAT * pfC10EnoylCoA) + C10HydroxyacylCoAMAT / (KmcrotC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C12EnoylCoAMAT / (KmcrotC12EnoylCoAMAT * pfC12EnoylCoA) + C12HydroxyacylCoAMAT / (KmcrotC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C14EnoylCoAMAT / (KmcrotC14EnoylCoAMAT * pfC14EnoylCoA) + C14HydroxyacylCoAMAT / (KmcrotC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C16EnoylCoAMAT / (KmcrotC16EnoylCoAMAT * pfC16EnoylCoA) + C16HydroxyacylCoAMAT / (KmcrotC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C4EnoylCoAMAT / (KmcrotC4EnoylCoAMAT * pfC4EnoylCoA) + C4HydroxyacylCoAMAT / (KmcrotC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KicrotC4KetoacylCoA * pfC4KetoacylCoA) + C6EnoylCoAMAT / (KmcrotC6EnoylCoAMAT * pfC6EnoylCoA) + C6HydroxyacylCoAMAT / (KmcrotC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C8EnoylCoAMAT / (KmcrotC8EnoylCoAMAT * pfC8EnoylCoA) + C8HydroxyacylCoAMAT / (KmcrotC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA))
vcrotC14 — C14EnoylCoAMAT = C14HydroxyacylCoAMAT

sfcrotC14 * Vcrot * (C14EnoylCoAMAT / (KmcrotC14EnoylCoAMAT * pfC14EnoylCoA) - C14HydroxyacylCoAMAT / (KeqcrotC14 * KmcrotC14EnoylCoAMAT * pfC14HydroxyacylCoA)) / (1 + C10EnoylCoAMAT / (KmcrotC10EnoylCoAMAT * pfC10EnoylCoA) + C10HydroxyacylCoAMAT / (KmcrotC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C12EnoylCoAMAT / (KmcrotC12EnoylCoAMAT * pfC12EnoylCoA) + C12HydroxyacylCoAMAT / (KmcrotC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C14EnoylCoAMAT / (KmcrotC14EnoylCoAMAT * pfC14EnoylCoA) + C14HydroxyacylCoAMAT / (KmcrotC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C16EnoylCoAMAT / (KmcrotC16EnoylCoAMAT * pfC16EnoylCoA) + C16HydroxyacylCoAMAT / (KmcrotC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C4EnoylCoAMAT / (KmcrotC4EnoylCoAMAT * pfC4EnoylCoA) + C4HydroxyacylCoAMAT / (KmcrotC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KicrotC4KetoacylCoA * pfC4KetoacylCoA) + C6EnoylCoAMAT / (KmcrotC6EnoylCoAMAT * pfC6EnoylCoA) + C6HydroxyacylCoAMAT / (KmcrotC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C8EnoylCoAMAT / (KmcrotC8EnoylCoAMAT * pfC8EnoylCoA) + C8HydroxyacylCoAMAT / (KmcrotC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA))
vcrotC16 — C16EnoylCoAMAT = C16HydroxyacylCoAMAT

sfcrotC16 * Vcrot * (C16EnoylCoAMAT / (KmcrotC16EnoylCoAMAT * pfC16EnoylCoA) - C16HydroxyacylCoAMAT / (KeqcrotC16 * KmcrotC16EnoylCoAMAT * pfC16HydroxyacylCoA)) / (1 + C10EnoylCoAMAT / (KmcrotC10EnoylCoAMAT * pfC10EnoylCoA) + C10HydroxyacylCoAMAT / (KmcrotC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C12EnoylCoAMAT / (KmcrotC12EnoylCoAMAT * pfC12EnoylCoA) + C12HydroxyacylCoAMAT / (KmcrotC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C14EnoylCoAMAT / (KmcrotC14EnoylCoAMAT * pfC14EnoylCoA) + C14HydroxyacylCoAMAT / (KmcrotC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C16EnoylCoAMAT / (KmcrotC16EnoylCoAMAT * pfC16EnoylCoA) + C16HydroxyacylCoAMAT / (KmcrotC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C4EnoylCoAMAT / (KmcrotC4EnoylCoAMAT * pfC4EnoylCoA) + C4HydroxyacylCoAMAT / (KmcrotC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KicrotC4KetoacylCoA * pfC4KetoacylCoA) + C6EnoylCoAMAT / (KmcrotC6EnoylCoAMAT * pfC6EnoylCoA) + C6HydroxyacylCoAMAT / (KmcrotC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C8EnoylCoAMAT / (KmcrotC8EnoylCoAMAT * pfC8EnoylCoA) + C8HydroxyacylCoAMAT / (KmcrotC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA))
vcrotC4 — C4EnoylCoAMAT = C4HydroxyacylCoAMAT

sfcrotC4 * Vcrot * (C4EnoylCoAMAT / (KmcrotC4EnoylCoAMAT * pfC4EnoylCoA) - C4HydroxyacylCoAMAT / (KeqcrotC4 * KmcrotC4EnoylCoAMAT * pfC4HydroxyacylCoA)) / (1 + C10EnoylCoAMAT / (KmcrotC10EnoylCoAMAT * pfC10EnoylCoA) + C10HydroxyacylCoAMAT / (KmcrotC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C12EnoylCoAMAT / (KmcrotC12EnoylCoAMAT * pfC12EnoylCoA) + C12HydroxyacylCoAMAT / (KmcrotC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C14EnoylCoAMAT / (KmcrotC14EnoylCoAMAT * pfC14EnoylCoA) + C14HydroxyacylCoAMAT / (KmcrotC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C16EnoylCoAMAT / (KmcrotC16EnoylCoAMAT * pfC16EnoylCoA) + C16HydroxyacylCoAMAT / (KmcrotC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C4EnoylCoAMAT / (KmcrotC4EnoylCoAMAT * pfC4EnoylCoA) + C4HydroxyacylCoAMAT / (KmcrotC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KicrotC4KetoacylCoA * pfC4KetoacylCoA) + C6EnoylCoAMAT / (KmcrotC6EnoylCoAMAT * pfC6EnoylCoA) + C6HydroxyacylCoAMAT / (KmcrotC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C8EnoylCoAMAT / (KmcrotC8EnoylCoAMAT * pfC8EnoylCoA) + C8HydroxyacylCoAMAT / (KmcrotC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA))
vcrotC6 — C6EnoylCoAMAT = C6HydroxyacylCoAMAT

sfcrotC6 * Vcrot * (C6EnoylCoAMAT / (KmcrotC6EnoylCoAMAT * pfC6EnoylCoA) - C6HydroxyacylCoAMAT / (KeqcrotC6 * KmcrotC6EnoylCoAMAT * pfC6HydroxyacylCoA)) / (1 + C10EnoylCoAMAT / (KmcrotC10EnoylCoAMAT * pfC10EnoylCoA) + C10HydroxyacylCoAMAT / (KmcrotC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C12EnoylCoAMAT / (KmcrotC12EnoylCoAMAT * pfC12EnoylCoA) + C12HydroxyacylCoAMAT / (KmcrotC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C14EnoylCoAMAT / (KmcrotC14EnoylCoAMAT * pfC14EnoylCoA) + C14HydroxyacylCoAMAT / (KmcrotC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C16EnoylCoAMAT / (KmcrotC16EnoylCoAMAT * pfC16EnoylCoA) + C16HydroxyacylCoAMAT / (KmcrotC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C4EnoylCoAMAT / (KmcrotC4EnoylCoAMAT * pfC4EnoylCoA) + C4HydroxyacylCoAMAT / (KmcrotC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KicrotC4KetoacylCoA * pfC4KetoacylCoA) + C6EnoylCoAMAT / (KmcrotC6EnoylCoAMAT * pfC6EnoylCoA) + C6HydroxyacylCoAMAT / (KmcrotC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C8EnoylCoAMAT / (KmcrotC8EnoylCoAMAT * pfC8EnoylCoA) + C8HydroxyacylCoAMAT / (KmcrotC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA))
vcrotC8 — C8EnoylCoAMAT = C8HydroxyacylCoAMAT

sfcrotC8 * Vcrot * (C8EnoylCoAMAT / (KmcrotC8EnoylCoAMAT * pfC8EnoylCoA) - C8HydroxyacylCoAMAT / (KeqcrotC8 * KmcrotC8EnoylCoAMAT * pfC8HydroxyacylCoA)) / (1 + C10EnoylCoAMAT / (KmcrotC10EnoylCoAMAT * pfC10EnoylCoA) + C10HydroxyacylCoAMAT / (KmcrotC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C12EnoylCoAMAT / (KmcrotC12EnoylCoAMAT * pfC12EnoylCoA) + C12HydroxyacylCoAMAT / (KmcrotC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C14EnoylCoAMAT / (KmcrotC14EnoylCoAMAT * pfC14EnoylCoA) + C14HydroxyacylCoAMAT / (KmcrotC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C16EnoylCoAMAT / (KmcrotC16EnoylCoAMAT * pfC16EnoylCoA) + C16HydroxyacylCoAMAT / (KmcrotC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C4EnoylCoAMAT / (KmcrotC4EnoylCoAMAT * pfC4EnoylCoA) + C4HydroxyacylCoAMAT / (KmcrotC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KicrotC4KetoacylCoA * pfC4KetoacylCoA) + C6EnoylCoAMAT / (KmcrotC6EnoylCoAMAT * pfC6EnoylCoA) + C6HydroxyacylCoAMAT / (KmcrotC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C8EnoylCoAMAT / (KmcrotC8EnoylCoAMAT * pfC8EnoylCoA) + C8HydroxyacylCoAMAT / (KmcrotC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA))
vmcadC10 — PMSox + C10AcylCoAMAT = PMSred + C10EnoylCoAMAT

sfmcadC10 * Vmcad * (C10AcylCoAMAT * PMSox / (KmmcadC10AcylCoAMAT * KmmcadPMSox * pfC10AcylCoA) - C10EnoylCoAMAT * PMSred / (KeqmcadC10 * KmmcadC10AcylCoAMAT * KmmcadPMSox * pfC10EnoylCoA)) / ((1 + C10AcylCoAMAT / (KmmcadC10AcylCoAMAT * pfC10AcylCoA) + C10EnoylCoAMAT / (KmmcadC10EnoylCoAMAT * pfC10EnoylCoA) + C12AcylCoAMAT / (KmmcadC12AcylCoAMAT * pfC12AcylCoA) + C12EnoylCoAMAT / (KmmcadC12EnoylCoAMAT * pfC12EnoylCoA) + C14AcylCoAMAT / (KmmcadC14AcylCoAMAT * pfC14AcylCoA) + C14EnoylCoAMAT / (KmmcadC14EnoylCoAMAT * pfC14EnoylCoA) + C16AcylCoAMAT / (KmmcadC16AcylCoAMAT * pfC16AcylCoA) + C16EnoylCoAMAT / (KmmcadC16EnoylCoAMAT * pfC16EnoylCoA) + C4AcylCoAMAT / (KmmcadC4AcylCoAMAT * pfC4AcylCoA) + C4EnoylCoAMAT / (KmmcadC4EnoylCoAMAT * pfC4EnoylCoA) + C6AcylCoAMAT / (KmmcadC6AcylCoAMAT * pfC6AcylCoA) + C6EnoylCoAMAT / (KmmcadC6EnoylCoAMAT * pfC6EnoylCoA) + C8AcylCoAMAT / (KmmcadC8AcylCoAMAT * pfC8AcylCoA) + C8EnoylCoAMAT / (KmmcadC8EnoylCoAMAT * pfC8EnoylCoA)) * (1 + PMSox / KmmcadPMSox + PMSred / KmmcadPMSred))
vmcadC12 — PMSox + C12AcylCoAMAT = PMSred + C12EnoylCoAMAT

sfmcadC12 * Vmcad * (C12AcylCoAMAT * PMSox / (KmmcadC12AcylCoAMAT * KmmcadPMSox * pfC12AcylCoA) - C12EnoylCoAMAT * PMSred / (KeqmcadC12 * KmmcadC12AcylCoAMAT * KmmcadPMSox * pfC12EnoylCoA)) / ((1 + C10AcylCoAMAT / (KmmcadC10AcylCoAMAT * pfC10AcylCoA) + C10EnoylCoAMAT / (KmmcadC10EnoylCoAMAT * pfC10EnoylCoA) + C12AcylCoAMAT / (KmmcadC12AcylCoAMAT * pfC12AcylCoA) + C12EnoylCoAMAT / (KmmcadC12EnoylCoAMAT * pfC12EnoylCoA) + C14AcylCoAMAT / (KmmcadC14AcylCoAMAT * pfC14AcylCoA) + C14EnoylCoAMAT / (KmmcadC14EnoylCoAMAT * pfC14EnoylCoA) + C16AcylCoAMAT / (KmmcadC16AcylCoAMAT * pfC16AcylCoA) + C16EnoylCoAMAT / (KmmcadC16EnoylCoAMAT * pfC16EnoylCoA) + C4AcylCoAMAT / (KmmcadC4AcylCoAMAT * pfC4AcylCoA) + C4EnoylCoAMAT / (KmmcadC4EnoylCoAMAT * pfC4EnoylCoA) + C6AcylCoAMAT / (KmmcadC6AcylCoAMAT * pfC6AcylCoA) + C6EnoylCoAMAT / (KmmcadC6EnoylCoAMAT * pfC6EnoylCoA) + C8AcylCoAMAT / (KmmcadC8AcylCoAMAT * pfC8AcylCoA) + C8EnoylCoAMAT / (KmmcadC8EnoylCoAMAT * pfC8EnoylCoA)) * (1 + PMSox / KmmcadPMSox + PMSred / KmmcadPMSred))
vmcadC14 — PMSox + C14AcylCoAMAT = PMSred + C14EnoylCoAMAT

sfmcadC14 * Vmcad * (C14AcylCoAMAT * PMSox / (KmmcadC14AcylCoAMAT * KmmcadPMSox * pfC14AcylCoA) - C14EnoylCoAMAT * PMSred / (KeqmcadC14 * KmmcadC14AcylCoAMAT * KmmcadPMSox * pfC14EnoylCoA)) / ((1 + C10AcylCoAMAT / (KmmcadC10AcylCoAMAT * pfC10AcylCoA) + C10EnoylCoAMAT / (KmmcadC10EnoylCoAMAT * pfC10EnoylCoA) + C12AcylCoAMAT / (KmmcadC12AcylCoAMAT * pfC12AcylCoA) + C12EnoylCoAMAT / (KmmcadC12EnoylCoAMAT * pfC12EnoylCoA) + C14AcylCoAMAT / (KmmcadC14AcylCoAMAT * pfC14AcylCoA) + C14EnoylCoAMAT / (KmmcadC14EnoylCoAMAT * pfC14EnoylCoA) + C16AcylCoAMAT / (KmmcadC16AcylCoAMAT * pfC16AcylCoA) + C16EnoylCoAMAT / (KmmcadC16EnoylCoAMAT * pfC16EnoylCoA) + C4AcylCoAMAT / (KmmcadC4AcylCoAMAT * pfC4AcylCoA) + C4EnoylCoAMAT / (KmmcadC4EnoylCoAMAT * pfC4EnoylCoA) + C6AcylCoAMAT / (KmmcadC6AcylCoAMAT * pfC6AcylCoA) + C6EnoylCoAMAT / (KmmcadC6EnoylCoAMAT * pfC6EnoylCoA) + C8AcylCoAMAT / (KmmcadC8AcylCoAMAT * pfC8AcylCoA) + C8EnoylCoAMAT / (KmmcadC8EnoylCoAMAT * pfC8EnoylCoA)) * (1 + PMSox / KmmcadPMSox + PMSred / KmmcadPMSred))
vmcadC16 — PMSox + C16AcylCoAMAT = PMSred + C16EnoylCoAMAT

sfmcadC16 * Vmcad * (C16AcylCoAMAT * PMSox / (KmmcadC16AcylCoAMAT * KmmcadPMSox * pfC16AcylCoA) - C16EnoylCoAMAT * PMSred / (KeqmcadC16 * KmmcadC16AcylCoAMAT * KmmcadPMSox * pfC16EnoylCoA)) / ((1 + C10AcylCoAMAT / (KmmcadC10AcylCoAMAT * pfC10AcylCoA) + C10EnoylCoAMAT / (KmmcadC10EnoylCoAMAT * pfC10EnoylCoA) + C12AcylCoAMAT / (KmmcadC12AcylCoAMAT * pfC12AcylCoA) + C12EnoylCoAMAT / (KmmcadC12EnoylCoAMAT * pfC12EnoylCoA) + C14AcylCoAMAT / (KmmcadC14AcylCoAMAT * pfC14AcylCoA) + C14EnoylCoAMAT / (KmmcadC14EnoylCoAMAT * pfC14EnoylCoA) + C16AcylCoAMAT / (KmmcadC16AcylCoAMAT * pfC16AcylCoA) + C16EnoylCoAMAT / (KmmcadC16EnoylCoAMAT * pfC16EnoylCoA) + C4AcylCoAMAT / (KmmcadC4AcylCoAMAT * pfC4AcylCoA) + C4EnoylCoAMAT / (KmmcadC4EnoylCoAMAT * pfC4EnoylCoA) + C6AcylCoAMAT / (KmmcadC6AcylCoAMAT * pfC6AcylCoA) + C6EnoylCoAMAT / (KmmcadC6EnoylCoAMAT * pfC6EnoylCoA) + C8AcylCoAMAT / (KmmcadC8AcylCoAMAT * pfC8AcylCoA) + C8EnoylCoAMAT / (KmmcadC8EnoylCoAMAT * pfC8EnoylCoA)) * (1 + PMSox / KmmcadPMSox + PMSred / KmmcadPMSred))
vmcadC4 — PMSox + C4AcylCoAMAT = PMSred + C4EnoylCoAMAT

sfmcadC4 * Vmcad * (C4AcylCoAMAT * PMSox / (KmmcadC4AcylCoAMAT * KmmcadPMSox * pfC4AcylCoA) - C4EnoylCoAMAT * PMSred / (KeqmcadC4 * KmmcadC4AcylCoAMAT * KmmcadPMSox * pfC4EnoylCoA)) / ((1 + C10AcylCoAMAT / (KmmcadC10AcylCoAMAT * pfC10AcylCoA) + C10EnoylCoAMAT / (KmmcadC10EnoylCoAMAT * pfC10EnoylCoA) + C12AcylCoAMAT / (KmmcadC12AcylCoAMAT * pfC12AcylCoA) + C12EnoylCoAMAT / (KmmcadC12EnoylCoAMAT * pfC12EnoylCoA) + C14AcylCoAMAT / (KmmcadC14AcylCoAMAT * pfC14AcylCoA) + C14EnoylCoAMAT / (KmmcadC14EnoylCoAMAT * pfC14EnoylCoA) + C16AcylCoAMAT / (KmmcadC16AcylCoAMAT * pfC16AcylCoA) + C16EnoylCoAMAT / (KmmcadC16EnoylCoAMAT * pfC16EnoylCoA) + C4AcylCoAMAT / (KmmcadC4AcylCoAMAT * pfC4AcylCoA) + C4EnoylCoAMAT / (KmmcadC4EnoylCoAMAT * pfC4EnoylCoA) + C6AcylCoAMAT / (KmmcadC6AcylCoAMAT * pfC6AcylCoA) + C6EnoylCoAMAT / (KmmcadC6EnoylCoAMAT * pfC6EnoylCoA) + C8AcylCoAMAT / (KmmcadC8AcylCoAMAT * pfC8AcylCoA) + C8EnoylCoAMAT / (KmmcadC8EnoylCoAMAT * pfC8EnoylCoA)) * (1 + PMSox / KmmcadPMSox + PMSred / KmmcadPMSred))
vmcadC6 — PMSox + C6AcylCoAMAT = PMSred + C6EnoylCoAMAT

sfmcadC6 * Vmcad * (C6AcylCoAMAT * PMSox / (KmmcadC6AcylCoAMAT * KmmcadPMSox * pfC6AcylCoA) - C6EnoylCoAMAT * PMSred / (KeqmcadC6 * KmmcadC6AcylCoAMAT * KmmcadPMSox * pfC6EnoylCoA)) / ((1 + C10AcylCoAMAT / (KmmcadC10AcylCoAMAT * pfC10AcylCoA) + C10EnoylCoAMAT / (KmmcadC10EnoylCoAMAT * pfC10EnoylCoA) + C12AcylCoAMAT / (KmmcadC12AcylCoAMAT * pfC12AcylCoA) + C12EnoylCoAMAT / (KmmcadC12EnoylCoAMAT * pfC12EnoylCoA) + C14AcylCoAMAT / (KmmcadC14AcylCoAMAT * pfC14AcylCoA) + C14EnoylCoAMAT / (KmmcadC14EnoylCoAMAT * pfC14EnoylCoA) + C16AcylCoAMAT / (KmmcadC16AcylCoAMAT * pfC16AcylCoA) + C16EnoylCoAMAT / (KmmcadC16EnoylCoAMAT * pfC16EnoylCoA) + C4AcylCoAMAT / (KmmcadC4AcylCoAMAT * pfC4AcylCoA) + C4EnoylCoAMAT / (KmmcadC4EnoylCoAMAT * pfC4EnoylCoA) + C6AcylCoAMAT / (KmmcadC6AcylCoAMAT * pfC6AcylCoA) + C6EnoylCoAMAT / (KmmcadC6EnoylCoAMAT * pfC6EnoylCoA) + C8AcylCoAMAT / (KmmcadC8AcylCoAMAT * pfC8AcylCoA) + C8EnoylCoAMAT / (KmmcadC8EnoylCoAMAT * pfC8EnoylCoA)) * (1 + PMSox / KmmcadPMSox + PMSred / KmmcadPMSred))
vmcadC8 — PMSox + C8AcylCoAMAT = PMSred + C8EnoylCoAMAT

sfmcadC8 * Vmcad * (C8AcylCoAMAT * PMSox / (KmmcadC8AcylCoAMAT * KmmcadPMSox * pfC8AcylCoA) - C8EnoylCoAMAT * PMSred / (KeqmcadC8 * KmmcadC8AcylCoAMAT * KmmcadPMSox * pfC8EnoylCoA)) / ((1 + C10AcylCoAMAT / (KmmcadC10AcylCoAMAT * pfC10AcylCoA) + C10EnoylCoAMAT / (KmmcadC10EnoylCoAMAT * pfC10EnoylCoA) + C12AcylCoAMAT / (KmmcadC12AcylCoAMAT * pfC12AcylCoA) + C12EnoylCoAMAT / (KmmcadC12EnoylCoAMAT * pfC12EnoylCoA) + C14AcylCoAMAT / (KmmcadC14AcylCoAMAT * pfC14AcylCoA) + C14EnoylCoAMAT / (KmmcadC14EnoylCoAMAT * pfC14EnoylCoA) + C16AcylCoAMAT / (KmmcadC16AcylCoAMAT * pfC16AcylCoA) + C16EnoylCoAMAT / (KmmcadC16EnoylCoAMAT * pfC16EnoylCoA) + C4AcylCoAMAT / (KmmcadC4AcylCoAMAT * pfC4AcylCoA) + C4EnoylCoAMAT / (KmmcadC4EnoylCoAMAT * pfC4EnoylCoA) + C6AcylCoAMAT / (KmmcadC6AcylCoAMAT * pfC6AcylCoA) + C6EnoylCoAMAT / (KmmcadC6EnoylCoAMAT * pfC6EnoylCoA) + C8AcylCoAMAT / (KmmcadC8AcylCoAMAT * pfC8AcylCoA) + C8EnoylCoAMAT / (KmmcadC8EnoylCoAMAT * pfC8EnoylCoA)) * (1 + PMSox / KmmcadPMSox + PMSred / KmmcadPMSred))
vmckatC10 — C10KetoacylCoAMAT = C8AcylCoAMAT + C2AcylCoAMAT

sfmckatC10 * Vmckat * (-(C2AcylCoAMAT * C8AcylCoAMAT / (KeqmckatC10 * KmmckatAcetylCoAMAT * KmmckatC10KetoacylCoAMAT * pfC2AcylCoA * pfC8AcylCoA)) + C10KetoacylCoAMAT * CoAMAT / (KmmckatC10KetoacylCoAMAT * pfC10KetoacylCoA * pfC2AcylCoA)) / ((1 + C10AcylCoAMAT / (KmmckatC10AcylCoAMAT * pfC10AcylCoA) + C10KetoacylCoAMAT / (KmmckatC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12AcylCoAMAT / (KmmckatC12AcylCoAMAT * pfC12AcylCoA) + C12KetoacylCoAMAT / (KmmckatC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14AcylCoAMAT / (KmmckatC14AcylCoAMAT * pfC14AcylCoA) + C14KetoacylCoAMAT / (KmmckatC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16KetoacylCoAMAT / (KmmckatC16KetoacylCoAMAT * pfC16KetoacylCoA) + C2AcylCoAMAT / (KmmckatC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCoAMAT / (KmmckatC4AcylCoAMAT * pfC4AcylCoA) + C4KetoacylCoAMAT / (KmmckatC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6AcylCoAMAT / (KmmckatC6AcylCoAMAT * pfC6AcylCoA) + C6KetoacylCoAMAT / (KmmckatC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8AcylCoAMAT / (KmmckatC8AcylCoAMAT * pfC8AcylCoA) + C8KetoacylCoAMAT / (KmmckatC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + C2AcylCoAMAT / (KmmckatAcetylCoAMAT * KmmckatC10CoAMAT) + CoAMAT / pfC2AcylCoA))
vmckatC12 — C12KetoacylCoAMAT = C2AcylCoAMAT + C10AcylCoAMAT

sfmckatC12 * Vmckat * (-(C10AcylCoAMAT * C2AcylCoAMAT / (KeqmckatC12 * KmmckatAcetylCoAMAT * KmmckatC12KetoacylCoAMAT * pfC10AcylCoA * pfC2AcylCoA)) + C12KetoacylCoAMAT * CoAMAT / (KmmckatC12KetoacylCoAMAT * pfC12KetoacylCoA * pfC2AcylCoA)) / ((1 + C10AcylCoAMAT / (KmmckatC10AcylCoAMAT * pfC10AcylCoA) + C10KetoacylCoAMAT / (KmmckatC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12AcylCoAMAT / (KmmckatC12AcylCoAMAT * pfC12AcylCoA) + C12KetoacylCoAMAT / (KmmckatC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14AcylCoAMAT / (KmmckatC14AcylCoAMAT * pfC14AcylCoA) + C14KetoacylCoAMAT / (KmmckatC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16KetoacylCoAMAT / (KmmckatC16KetoacylCoAMAT * pfC16KetoacylCoA) + C2AcylCoAMAT / (KmmckatC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCoAMAT / (KmmckatC4AcylCoAMAT * pfC4AcylCoA) + C4KetoacylCoAMAT / (KmmckatC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6AcylCoAMAT / (KmmckatC6AcylCoAMAT * pfC6AcylCoA) + C6KetoacylCoAMAT / (KmmckatC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8AcylCoAMAT / (KmmckatC8AcylCoAMAT * pfC8AcylCoA) + C8KetoacylCoAMAT / (KmmckatC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + C2AcylCoAMAT / (KmmckatAcetylCoAMAT * KmmckatC12CoAMAT) + CoAMAT / pfC2AcylCoA))
vmckatC14 — C14KetoacylCoAMAT = C2AcylCoAMAT + C12AcylCoAMAT

sfmckatC14 * Vmckat * (-(C12AcylCoAMAT * C2AcylCoAMAT / (KeqmckatC14 * KmmckatAcetylCoAMAT * KmmckatC14KetoacylCoAMAT * pfC12AcylCoA * pfC2AcylCoA)) + C14KetoacylCoAMAT * CoAMAT / (KmmckatC14KetoacylCoAMAT * pfC14KetoacylCoA * pfC2AcylCoA)) / ((1 + C10AcylCoAMAT / (KmmckatC10AcylCoAMAT * pfC10AcylCoA) + C10KetoacylCoAMAT / (KmmckatC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12AcylCoAMAT / (KmmckatC12AcylCoAMAT * pfC12AcylCoA) + C12KetoacylCoAMAT / (KmmckatC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14AcylCoAMAT / (KmmckatC14AcylCoAMAT * pfC14AcylCoA) + C14KetoacylCoAMAT / (KmmckatC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16KetoacylCoAMAT / (KmmckatC16KetoacylCoAMAT * pfC16KetoacylCoA) + C2AcylCoAMAT / (KmmckatC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCoAMAT / (KmmckatC4AcylCoAMAT * pfC4AcylCoA) + C4KetoacylCoAMAT / (KmmckatC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6AcylCoAMAT / (KmmckatC6AcylCoAMAT * pfC6AcylCoA) + C6KetoacylCoAMAT / (KmmckatC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8AcylCoAMAT / (KmmckatC8AcylCoAMAT * pfC8AcylCoA) + C8KetoacylCoAMAT / (KmmckatC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + C2AcylCoAMAT / (KmmckatAcetylCoAMAT * KmmckatC14CoAMAT) + CoAMAT / pfC2AcylCoA))
vmckatC16 — C16KetoacylCoAMAT = C2AcylCoAMAT + C14AcylCoAMAT

sfmckatC16 * Vmckat * (-(C14AcylCoAMAT * C2AcylCoAMAT / (KeqmckatC16 * KmmckatAcetylCoAMAT * KmmckatC16KetoacylCoAMAT * pfC14AcylCoA * pfC2AcylCoA)) + C16KetoacylCoAMAT * CoAMAT / (KmmckatC16KetoacylCoAMAT * pfC16KetoacylCoA * pfC2AcylCoA)) / ((1 + C10AcylCoAMAT / (KmmckatC10AcylCoAMAT * pfC10AcylCoA) + C10KetoacylCoAMAT / (KmmckatC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12AcylCoAMAT / (KmmckatC12AcylCoAMAT * pfC12AcylCoA) + C12KetoacylCoAMAT / (KmmckatC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14AcylCoAMAT / (KmmckatC14AcylCoAMAT * pfC14AcylCoA) + C14KetoacylCoAMAT / (KmmckatC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16KetoacylCoAMAT / (KmmckatC16KetoacylCoAMAT * pfC16KetoacylCoA) + C2AcylCoAMAT / (KmmckatC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCoAMAT / (KmmckatC4AcylCoAMAT * pfC4AcylCoA) + C4KetoacylCoAMAT / (KmmckatC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6AcylCoAMAT / (KmmckatC6AcylCoAMAT * pfC6AcylCoA) + C6KetoacylCoAMAT / (KmmckatC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8AcylCoAMAT / (KmmckatC8AcylCoAMAT * pfC8AcylCoA) + C8KetoacylCoAMAT / (KmmckatC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + C2AcylCoAMAT / (KmmckatAcetylCoAMAT * KmmckatC16CoAMAT) + CoAMAT / pfC2AcylCoA))
vmckatC4 — C4KetoacylCoAMAT = C2AcylCoAMAT

sfmckatC4 * Vmckat * (-(pow(C2AcylCoAMAT, 2) / (KeqmckatC4 * KmmckatAcetylCoAMAT * KmmckatC4KetoacylCoAMAT * pow(pfC2AcylCoA, 2))) + C4KetoacylCoAMAT * CoAMAT / (KmmckatC4KetoacylCoAMAT * pfC2AcylCoA * pfC4KetoacylCoA)) / ((1 + C10AcylCoAMAT / (KmmckatC10AcylCoAMAT * pfC10AcylCoA) + C10KetoacylCoAMAT / (KmmckatC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12AcylCoAMAT / (KmmckatC12AcylCoAMAT * pfC12AcylCoA) + C12KetoacylCoAMAT / (KmmckatC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14AcylCoAMAT / (KmmckatC14AcylCoAMAT * pfC14AcylCoA) + C14KetoacylCoAMAT / (KmmckatC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16KetoacylCoAMAT / (KmmckatC16KetoacylCoAMAT * pfC16KetoacylCoA) + C2AcylCoAMAT / (KmmckatC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCoAMAT / (KmmckatC4AcylCoAMAT * pfC4AcylCoA) + C4KetoacylCoAMAT / (KmmckatC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6AcylCoAMAT / (KmmckatC6AcylCoAMAT * pfC6AcylCoA) + C6KetoacylCoAMAT / (KmmckatC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8AcylCoAMAT / (KmmckatC8AcylCoAMAT * pfC8AcylCoA) + C8KetoacylCoAMAT / (KmmckatC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + C2AcylCoAMAT / (KmmckatAcetylCoAMAT * KmmckatC4CoAMAT) + CoAMAT / pfC2AcylCoA))
vmckatC6 — C6KetoacylCoAMAT = C4AcylCoAMAT + C2AcylCoAMAT

sfmckatC6 * Vmckat * (-(C2AcylCoAMAT * C4AcylCoAMAT / (KeqmckatC6 * KmmckatAcetylCoAMAT * KmmckatC6KetoacylCoAMAT * pfC2AcylCoA * pfC4AcylCoA)) + C6KetoacylCoAMAT * CoAMAT / (KmmckatC6KetoacylCoAMAT * pfC2AcylCoA * pfC6KetoacylCoA)) / ((1 + C10AcylCoAMAT / (KmmckatC10AcylCoAMAT * pfC10AcylCoA) + C10KetoacylCoAMAT / (KmmckatC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12AcylCoAMAT / (KmmckatC12AcylCoAMAT * pfC12AcylCoA) + C12KetoacylCoAMAT / (KmmckatC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14AcylCoAMAT / (KmmckatC14AcylCoAMAT * pfC14AcylCoA) + C14KetoacylCoAMAT / (KmmckatC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16KetoacylCoAMAT / (KmmckatC16KetoacylCoAMAT * pfC16KetoacylCoA) + C2AcylCoAMAT / (KmmckatC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCoAMAT / (KmmckatC4AcylCoAMAT * pfC4AcylCoA) + C4KetoacylCoAMAT / (KmmckatC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6AcylCoAMAT / (KmmckatC6AcylCoAMAT * pfC6AcylCoA) + C6KetoacylCoAMAT / (KmmckatC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8AcylCoAMAT / (KmmckatC8AcylCoAMAT * pfC8AcylCoA) + C8KetoacylCoAMAT / (KmmckatC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + C2AcylCoAMAT / (KmmckatAcetylCoAMAT * KmmckatC6CoAMAT) + CoAMAT / pfC2AcylCoA))
vmckatC8 — C8KetoacylCoAMAT = C6AcylCoAMAT + C2AcylCoAMAT

sfmckatC8 * Vmckat * (-(C2AcylCoAMAT * C6AcylCoAMAT / (KeqmckatC8 * KmmckatAcetylCoAMAT * KmmckatC8KetoacylCoAMAT * pfC2AcylCoA * pfC6AcylCoA)) + C8KetoacylCoAMAT * CoAMAT / (KmmckatC8KetoacylCoAMAT * pfC2AcylCoA * pfC8KetoacylCoA)) / ((1 + C10AcylCoAMAT / (KmmckatC10AcylCoAMAT * pfC10AcylCoA) + C10KetoacylCoAMAT / (KmmckatC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12AcylCoAMAT / (KmmckatC12AcylCoAMAT * pfC12AcylCoA) + C12KetoacylCoAMAT / (KmmckatC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14AcylCoAMAT / (KmmckatC14AcylCoAMAT * pfC14AcylCoA) + C14KetoacylCoAMAT / (KmmckatC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16KetoacylCoAMAT / (KmmckatC16KetoacylCoAMAT * pfC16KetoacylCoA) + C2AcylCoAMAT / (KmmckatC2AcylCoAMAT * pfC2AcylCoA) + C4AcylCoAMAT / (KmmckatC4AcylCoAMAT * pfC4AcylCoA) + C4KetoacylCoAMAT / (KmmckatC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6AcylCoAMAT / (KmmckatC6AcylCoAMAT * pfC6AcylCoA) + C6KetoacylCoAMAT / (KmmckatC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8AcylCoAMAT / (KmmckatC8AcylCoAMAT * pfC8AcylCoA) + C8KetoacylCoAMAT / (KmmckatC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + C2AcylCoAMAT / (KmmckatAcetylCoAMAT * KmmckatC8CoAMAT) + CoAMAT / pfC2AcylCoA))
vmschadC10 — NAD + C10HydroxyacylCoAMAT = NADH + C10KetoacylCoAMAT

sfmschadC10 * Vmschad * (C10HydroxyacylCoAMAT * NAD / (KmmschadC10HydroxyacylCoAMAT * KmmschadNADMAT * pfC10HydroxyacylCoA) - C10KetoacylCoAMAT * NADH / (KeqmschadC10 * KmmschadC10HydroxyacylCoAMAT * KmmschadNADMAT * pfC10KetoacylCoA)) / ((1 + C10HydroxyacylCoAMAT / (KmmschadC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C10KetoacylCoAMAT / (KmmschadC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12HydroxyacylCoAMAT / (KmmschadC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C12KetoacylCoAMAT / (KmmschadC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14HydroxyacylCoAMAT / (KmmschadC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C14KetoacylCoAMAT / (KmmschadC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16HydroxyacylCoAMAT / (KmmschadC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C16KetoacylCoAMAT / (KmmschadC16KetoacylCoAMAT * pfC16KetoacylCoA) + C4HydroxyacylCoAMAT / (KmmschadC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KmmschadC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6HydroxyacylCoAMAT / (KmmschadC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C6KetoacylCoAMAT / (KmmschadC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8HydroxyacylCoAMAT / (KmmschadC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA) + C8KetoacylCoAMAT / (KmmschadC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + NAD / KmmschadNADMAT + NADH / KmmschadNADHMAT))
vmschadC12 — NAD + C12HydroxyacylCoAMAT = NADH + C12KetoacylCoAMAT

sfmschadC12 * Vmschad * (C12HydroxyacylCoAMAT * NAD / (KmmschadC12HydroxyacylCoAMAT * KmmschadNADMAT * pfC12HydroxyacylCoA) - C12KetoacylCoAMAT * NADH / (KeqmschadC12 * KmmschadC12HydroxyacylCoAMAT * KmmschadNADMAT * pfC12KetoacylCoA)) / ((1 + C10HydroxyacylCoAMAT / (KmmschadC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C10KetoacylCoAMAT / (KmmschadC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12HydroxyacylCoAMAT / (KmmschadC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C12KetoacylCoAMAT / (KmmschadC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14HydroxyacylCoAMAT / (KmmschadC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C14KetoacylCoAMAT / (KmmschadC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16HydroxyacylCoAMAT / (KmmschadC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C16KetoacylCoAMAT / (KmmschadC16KetoacylCoAMAT * pfC16KetoacylCoA) + C4HydroxyacylCoAMAT / (KmmschadC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KmmschadC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6HydroxyacylCoAMAT / (KmmschadC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C6KetoacylCoAMAT / (KmmschadC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8HydroxyacylCoAMAT / (KmmschadC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA) + C8KetoacylCoAMAT / (KmmschadC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + NAD / KmmschadNADMAT + NADH / KmmschadNADHMAT))
vmschadC14 — NAD + C14HydroxyacylCoAMAT = NADH + C14KetoacylCoAMAT

sfmschadC14 * Vmschad * (C14HydroxyacylCoAMAT * NAD / (KmmschadC14HydroxyacylCoAMAT * KmmschadNADMAT * pfC14HydroxyacylCoA) - C14KetoacylCoAMAT * NADH / (KeqmschadC14 * KmmschadC14HydroxyacylCoAMAT * KmmschadNADMAT * pfC14KetoacylCoA)) / ((1 + C10HydroxyacylCoAMAT / (KmmschadC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C10KetoacylCoAMAT / (KmmschadC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12HydroxyacylCoAMAT / (KmmschadC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C12KetoacylCoAMAT / (KmmschadC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14HydroxyacylCoAMAT / (KmmschadC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C14KetoacylCoAMAT / (KmmschadC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16HydroxyacylCoAMAT / (KmmschadC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C16KetoacylCoAMAT / (KmmschadC16KetoacylCoAMAT * pfC16KetoacylCoA) + C4HydroxyacylCoAMAT / (KmmschadC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KmmschadC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6HydroxyacylCoAMAT / (KmmschadC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C6KetoacylCoAMAT / (KmmschadC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8HydroxyacylCoAMAT / (KmmschadC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA) + C8KetoacylCoAMAT / (KmmschadC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + NAD / KmmschadNADMAT + NADH / KmmschadNADHMAT))
vmschadC16 — NAD + C16HydroxyacylCoAMAT = NADH + C16KetoacylCoAMAT

sfmschadC16 * Vmschad * (C16HydroxyacylCoAMAT * NAD / (KmmschadC16HydroxyacylCoAMAT * KmmschadNADMAT * pfC16HydroxyacylCoA) - C16KetoacylCoAMAT * NADH / (KeqmschadC16 * KmmschadC16HydroxyacylCoAMAT * KmmschadNADMAT * pfC16KetoacylCoA)) / ((1 + C10HydroxyacylCoAMAT / (KmmschadC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C10KetoacylCoAMAT / (KmmschadC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12HydroxyacylCoAMAT / (KmmschadC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C12KetoacylCoAMAT / (KmmschadC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14HydroxyacylCoAMAT / (KmmschadC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C14KetoacylCoAMAT / (KmmschadC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16HydroxyacylCoAMAT / (KmmschadC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C16KetoacylCoAMAT / (KmmschadC16KetoacylCoAMAT * pfC16KetoacylCoA) + C4HydroxyacylCoAMAT / (KmmschadC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KmmschadC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6HydroxyacylCoAMAT / (KmmschadC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C6KetoacylCoAMAT / (KmmschadC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8HydroxyacylCoAMAT / (KmmschadC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA) + C8KetoacylCoAMAT / (KmmschadC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + NAD / KmmschadNADMAT + NADH / KmmschadNADHMAT))
vmschadC4 — NAD + C4HydroxyacylCoAMAT = NADH + C4KetoacylCoAMAT

sfmschadC4 * Vmschad * (C4HydroxyacylCoAMAT * NAD / (KmmschadC4HydroxyacylCoAMAT * KmmschadNADMAT * pfC4HydroxyacylCoA) - C4KetoacylCoAMAT * NADH / (KeqmschadC4 * KmmschadC4HydroxyacylCoAMAT * KmmschadNADMAT * pfC4KetoacylCoA)) / ((1 + C10HydroxyacylCoAMAT / (KmmschadC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C10KetoacylCoAMAT / (KmmschadC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12HydroxyacylCoAMAT / (KmmschadC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C12KetoacylCoAMAT / (KmmschadC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14HydroxyacylCoAMAT / (KmmschadC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C14KetoacylCoAMAT / (KmmschadC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16HydroxyacylCoAMAT / (KmmschadC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C16KetoacylCoAMAT / (KmmschadC16KetoacylCoAMAT * pfC16KetoacylCoA) + C4HydroxyacylCoAMAT / (KmmschadC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KmmschadC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6HydroxyacylCoAMAT / (KmmschadC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C6KetoacylCoAMAT / (KmmschadC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8HydroxyacylCoAMAT / (KmmschadC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA) + C8KetoacylCoAMAT / (KmmschadC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + NAD / KmmschadNADMAT + NADH / KmmschadNADHMAT))
vmschadC6 — NAD + C6HydroxyacylCoAMAT = NADH + C6KetoacylCoAMAT

sfmschadC6 * Vmschad * (C6HydroxyacylCoAMAT * NAD / (KmmschadC6HydroxyacylCoAMAT * KmmschadNADMAT * pfC6HydroxyacylCoA) - C6KetoacylCoAMAT * NADH / (KeqmschadC6 * KmmschadC6HydroxyacylCoAMAT * KmmschadNADMAT * pfC6KetoacylCoA)) / ((1 + C10HydroxyacylCoAMAT / (KmmschadC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C10KetoacylCoAMAT / (KmmschadC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12HydroxyacylCoAMAT / (KmmschadC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C12KetoacylCoAMAT / (KmmschadC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14HydroxyacylCoAMAT / (KmmschadC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C14KetoacylCoAMAT / (KmmschadC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16HydroxyacylCoAMAT / (KmmschadC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C16KetoacylCoAMAT / (KmmschadC16KetoacylCoAMAT * pfC16KetoacylCoA) + C4HydroxyacylCoAMAT / (KmmschadC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KmmschadC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6HydroxyacylCoAMAT / (KmmschadC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C6KetoacylCoAMAT / (KmmschadC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8HydroxyacylCoAMAT / (KmmschadC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA) + C8KetoacylCoAMAT / (KmmschadC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + NAD / KmmschadNADMAT + NADH / KmmschadNADHMAT))
vmschadC8 — NAD + C8HydroxyacylCoAMAT = NADH + C8KetoacylCoAMAT

sfmschadC8 * Vmschad * (C8HydroxyacylCoAMAT * NAD / (KmmschadC8HydroxyacylCoAMAT * KmmschadNADMAT * pfC8HydroxyacylCoA) - C8KetoacylCoAMAT * NADH / (KeqmschadC8 * KmmschadC8HydroxyacylCoAMAT * KmmschadNADMAT * pfC8KetoacylCoA)) / ((1 + C10HydroxyacylCoAMAT / (KmmschadC10HydroxyacylCoAMAT * pfC10HydroxyacylCoA) + C10KetoacylCoAMAT / (KmmschadC10KetoacylCoAMAT * pfC10KetoacylCoA) + C12HydroxyacylCoAMAT / (KmmschadC12HydroxyacylCoAMAT * pfC12HydroxyacylCoA) + C12KetoacylCoAMAT / (KmmschadC12KetoacylCoAMAT * pfC12KetoacylCoA) + C14HydroxyacylCoAMAT / (KmmschadC14HydroxyacylCoAMAT * pfC14HydroxyacylCoA) + C14KetoacylCoAMAT / (KmmschadC14KetoacylCoAMAT * pfC14KetoacylCoA) + C16HydroxyacylCoAMAT / (KmmschadC16HydroxyacylCoAMAT * pfC16HydroxyacylCoA) + C16KetoacylCoAMAT / (KmmschadC16KetoacylCoAMAT * pfC16KetoacylCoA) + C4HydroxyacylCoAMAT / (KmmschadC4HydroxyacylCoAMAT * pfC4HydroxyacylCoA) + C4KetoacylCoAMAT / (KmmschadC4KetoacylCoAMAT * pfC4KetoacylCoA) + C6HydroxyacylCoAMAT / (KmmschadC6HydroxyacylCoAMAT * pfC6HydroxyacylCoA) + C6KetoacylCoAMAT / (KmmschadC6KetoacylCoAMAT * pfC6KetoacylCoA) + C8HydroxyacylCoAMAT / (KmmschadC8HydroxyacylCoAMAT * pfC8HydroxyacylCoA) + C8KetoacylCoAMAT / (KmmschadC8KetoacylCoAMAT * pfC8KetoacylCoA)) * (1 + NAD / KmmschadNADMAT + NADH / KmmschadNADHMAT))
vmtpC10 — NAD + C10EnoylCoAMAT = NADH + C8AcylCoAMAT + C2AcylCoAMAT

sfmtpC10 * Vmtp * (pfC10EnoylCoA * C10EnoylCoAMAT * CoAMAT * NAD / (KmmtpC10CoAMAT * KmmtpC10EnoylCoAMAT * KmmtpNADMAT) - pfC2AcylCoA * pfC8AcylCoA * C2AcylCoAMAT * C8AcylCoAMAT * NADH / (KeqmtpC10 * KmmtpC10CoAMAT * KmmtpC10EnoylCoAMAT * KmmtpNADMAT)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmmtpC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmmtpC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmmtpC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmmtpC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmmtpC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmmtpC14EnoylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmmtpC16EnoylCoAMAT + pfC4AcylCoA * C4AcylCoAMAT / KmmtpC4AcylCoAMAT + pfC6AcylCoA * C6AcylCoAMAT / KmmtpC6AcylCoAMAT + pfC6EnoylCoA * C6EnoylCoAMAT / KmmtpC6EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmmtpC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmmtpC8EnoylCoAMAT) * (1 + pfC2AcylCoA * C2AcylCoAMAT / KmmtpAcetylCoAMAT + CoAMAT / KmmtpC10CoAMAT) * (1 + NAD / KmmtpNADMAT + NADH / KmmtpNADHMAT))
vmtpC12 — NAD + C12EnoylCoAMAT = NADH + C2AcylCoAMAT + C10AcylCoAMAT

sfmtpC12 * Vmtp * (pfC12EnoylCoA * C12EnoylCoAMAT * CoAMAT * NAD / (KmmtpC12CoAMAT * KmmtpC12EnoylCoAMAT * KmmtpNADMAT) - pfC10AcylCoA * pfC2AcylCoA * C10AcylCoAMAT * C2AcylCoAMAT * NADH / (KeqmtpC12 * KmmtpC12CoAMAT * KmmtpC12EnoylCoAMAT * KmmtpNADMAT)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmmtpC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmmtpC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmmtpC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmmtpC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmmtpC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmmtpC14EnoylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmmtpC16EnoylCoAMAT + pfC4AcylCoA * C4AcylCoAMAT / KmmtpC4AcylCoAMAT + pfC6AcylCoA * C6AcylCoAMAT / KmmtpC6AcylCoAMAT + pfC6EnoylCoA * C6EnoylCoAMAT / KmmtpC6EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmmtpC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmmtpC8EnoylCoAMAT) * (1 + pfC2AcylCoA * C2AcylCoAMAT / KmmtpAcetylCoAMAT + CoAMAT / KmmtpC12CoAMAT) * (1 + NAD / KmmtpNADMAT + NADH / KmmtpNADHMAT))
vmtpC14 — NAD + C14EnoylCoAMAT = NADH + C2AcylCoAMAT + C12AcylCoAMAT

sfmtpC14 * Vmtp * (pfC14EnoylCoA * C14EnoylCoAMAT * CoAMAT * NAD / (KmmtpC14CoAMAT * KmmtpC14EnoylCoAMAT * KmmtpNADMAT) - pfC12AcylCoA * pfC2AcylCoA * C12AcylCoAMAT * C2AcylCoAMAT * NADH / (KeqmtpC14 * KmmtpC14CoAMAT * KmmtpC14EnoylCoAMAT * KmmtpNADMAT)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmmtpC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmmtpC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmmtpC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmmtpC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmmtpC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmmtpC14EnoylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmmtpC16EnoylCoAMAT + pfC4AcylCoA * C4AcylCoAMAT / KmmtpC4AcylCoAMAT + pfC6AcylCoA * C6AcylCoAMAT / KmmtpC6AcylCoAMAT + pfC6EnoylCoA * C6EnoylCoAMAT / KmmtpC6EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmmtpC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmmtpC8EnoylCoAMAT) * (1 + pfC2AcylCoA * C2AcylCoAMAT / KmmtpAcetylCoAMAT + CoAMAT / KmmtpC14CoAMAT) * (1 + NAD / KmmtpNADMAT + NADH / KmmtpNADHMAT))
vmtpC16 — NAD + C16EnoylCoAMAT = NADH + C2AcylCoAMAT + C14AcylCoAMAT

sfmtpC16 * Vmtp * (pfC16EnoylCoA * C16EnoylCoAMAT * CoAMAT * NAD / (KmmtpC16CoAMAT * KmmtpC16EnoylCoAMAT * KmmtpNADMAT) - pfC14AcylCoA * pfC2AcylCoA * C14AcylCoAMAT * C2AcylCoAMAT * NADH / (KeqmtpC16 * KmmtpC16CoAMAT * KmmtpC16EnoylCoAMAT * KmmtpNADMAT)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmmtpC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmmtpC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmmtpC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmmtpC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmmtpC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmmtpC14EnoylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmmtpC16EnoylCoAMAT + pfC4AcylCoA * C4AcylCoAMAT / KmmtpC4AcylCoAMAT + pfC6AcylCoA * C6AcylCoAMAT / KmmtpC6AcylCoAMAT + pfC6EnoylCoA * C6EnoylCoAMAT / KmmtpC6EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmmtpC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmmtpC8EnoylCoAMAT) * (1 + pfC2AcylCoA * C2AcylCoAMAT / KmmtpAcetylCoAMAT + CoAMAT / KmmtpC16CoAMAT) * (1 + NAD / KmmtpNADMAT + NADH / KmmtpNADHMAT))
vmtpC6 — NAD + C6EnoylCoAMAT = NADH + C2AcylCoAMAT

sfmtpC6 * Vmtp * (pfC6EnoylCoA * C6EnoylCoAMAT * CoAMAT * NAD / (KmmtpC6CoAMAT * KmmtpC6EnoylCoAMAT * KmmtpNADMAT) - pfC2AcylCoA * pfC4AcylCoA * C2AcylCoAMAT * C4AcylCoAMAT * NADH / (KeqmtpC6 * KmmtpC6CoAMAT * KmmtpC6EnoylCoAMAT * KmmtpNADMAT)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmmtpC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmmtpC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmmtpC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmmtpC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmmtpC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmmtpC14EnoylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmmtpC16EnoylCoAMAT + pfC4AcylCoA * C4AcylCoAMAT / KmmtpC4AcylCoAMAT + pfC6AcylCoA * C6AcylCoAMAT / KmmtpC6AcylCoAMAT + pfC6EnoylCoA * C6EnoylCoAMAT / KmmtpC6EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmmtpC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmmtpC8EnoylCoAMAT) * (1 + pfC2AcylCoA * C2AcylCoAMAT / KmmtpAcetylCoAMAT + CoAMAT / KmmtpC6CoAMAT) * (1 + NAD / KmmtpNADMAT + NADH / KmmtpNADHMAT))
vmtpC8 — NAD + C8EnoylCoAMAT = NADH + C6AcylCoAMAT + C2AcylCoAMAT

sfmtpC8 * Vmtp * (pfC8EnoylCoA * C8EnoylCoAMAT * CoAMAT * NAD / (KmmtpC8CoAMAT * KmmtpC8EnoylCoAMAT * KmmtpNADMAT) - pfC2AcylCoA * pfC6AcylCoA * C2AcylCoAMAT * C6AcylCoAMAT * NADH / (KeqmtpC8 * KmmtpC8CoAMAT * KmmtpC8EnoylCoAMAT * KmmtpNADMAT)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmmtpC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmmtpC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmmtpC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmmtpC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmmtpC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmmtpC14EnoylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmmtpC16EnoylCoAMAT + pfC4AcylCoA * C4AcylCoAMAT / KmmtpC4AcylCoAMAT + pfC6AcylCoA * C6AcylCoAMAT / KmmtpC6AcylCoAMAT + pfC6EnoylCoA * C6EnoylCoAMAT / KmmtpC6EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmmtpC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmmtpC8EnoylCoAMAT) * (1 + pfC2AcylCoA * C2AcylCoAMAT / KmmtpAcetylCoAMAT + CoAMAT / KmmtpC8CoAMAT) * (1 + NAD / KmmtpNADMAT + NADH / KmmtpNADHMAT))
vscadC4 — PMSox + C4AcylCoAMAT = PMSred + C4EnoylCoAMAT

sfscadC4 * Vscad * (C4AcylCoAMAT * PMSox / (KmscadC4AcylCoAMAT * KmscadPMSox * pfC4AcylCoA) - C4EnoylCoAMAT * PMSred / (KeqscadC4 * KmscadC4AcylCoAMAT * KmscadPMSox * pfC4EnoylCoA)) / ((1 + C4AcylCoAMAT / (KmscadC4AcylCoAMAT * pfC4AcylCoA) + C4EnoylCoAMAT / (KmscadC4EnoylCoAMAT * pfC4EnoylCoA) + C6AcylCoAMAT / (KmscadC6AcylCoAMAT * pfC6AcylCoA) + C6EnoylCoAMAT / (KmscadC6EnoylCoAMAT * pfC6EnoylCoA)) * (1 + PMSox / KmscadPMSox + PMSred / KmscadPMSred))
vscadC6 — PMSox + C6AcylCoAMAT = PMSred + C6EnoylCoAMAT

sfscadC6 * Vscad * (C6AcylCoAMAT * PMSox / (KmscadC6AcylCoAMAT * KmscadPMSox * pfC6AcylCoA) - C6EnoylCoAMAT * PMSred / (KeqscadC6 * KmscadC6AcylCoAMAT * KmscadPMSox * pfC6EnoylCoA)) / ((1 + C4AcylCoAMAT / (KmscadC4AcylCoAMAT * pfC4AcylCoA) + C4EnoylCoAMAT / (KmscadC4EnoylCoAMAT * pfC4EnoylCoA) + C6AcylCoAMAT / (KmscadC6AcylCoAMAT * pfC6AcylCoA) + C6EnoylCoAMAT / (KmscadC6EnoylCoAMAT * pfC6EnoylCoA)) * (1 + PMSox / KmscadPMSox + PMSred / KmscadPMSred))
vvlcadC10 — PMSox + C10AcylCoAMAT = PMSred + C10EnoylCoAMAT

sfvlcadC10 * Vvlcad * (pfC10AcylCoA * C10AcylCoAMAT * PMSox / (KmvlcadC10AcylCoAMAT * KmvlcadPMSox) - pfC10EnoylCoA * C10EnoylCoAMAT * PMSred / (KeqvlcadC10 * KmvlcadC10AcylCoAMAT * KmvlcadPMSox)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmvlcadC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmvlcadC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmvlcadC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmvlcadC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmvlcadC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmvlcadC14EnoylCoAMAT + pfC16AcylCoA * C16AcylCoAMAT / KmvlcadC16AcylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmvlcadC16EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmvlcadC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmvlcadC8EnoylCoAMAT) * (1 + PMSox / KmvlcadPMSox + PMSred / KmvlcadPMSred))
vvlcadC12 — PMSox + C12AcylCoAMAT = PMSred + C12EnoylCoAMAT

sfvlcadC12 * Vvlcad * (pfC12AcylCoA * C12AcylCoAMAT * PMSox / (KmvlcadC12AcylCoAMAT * KmvlcadPMSox) - pfC12EnoylCoA * C12EnoylCoAMAT * PMSred / (KeqvlcadC12 * KmvlcadC12AcylCoAMAT * KmvlcadPMSox)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmvlcadC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmvlcadC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmvlcadC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmvlcadC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmvlcadC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmvlcadC14EnoylCoAMAT + pfC16AcylCoA * C16AcylCoAMAT / KmvlcadC16AcylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmvlcadC16EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmvlcadC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmvlcadC8EnoylCoAMAT) * (1 + PMSox / KmvlcadPMSox + PMSred / KmvlcadPMSred))
vvlcadC14 — PMSox + C14AcylCoAMAT = PMSred + C14EnoylCoAMAT

sfvlcadC14 * Vvlcad * (pfC14AcylCoA * C14AcylCoAMAT * PMSox / (KmvlcadC14AcylCoAMAT * KmvlcadPMSox) - pfC14EnoylCoA * C14EnoylCoAMAT * PMSred / (KeqvlcadC14 * KmvlcadC14AcylCoAMAT * KmvlcadPMSox)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmvlcadC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmvlcadC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmvlcadC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmvlcadC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmvlcadC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmvlcadC14EnoylCoAMAT + pfC16AcylCoA * C16AcylCoAMAT / KmvlcadC16AcylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmvlcadC16EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmvlcadC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmvlcadC8EnoylCoAMAT) * (1 + PMSox / KmvlcadPMSox + PMSred / KmvlcadPMSred))
vvlcadC16 — PMSox + C16AcylCoAMAT = PMSred + C16EnoylCoAMAT

sfvlcadC16 * Vvlcad * (pfC16AcylCoA * C16AcylCoAMAT * PMSox / (KmvlcadC16AcylCoAMAT * KmvlcadPMSox) - pfC16EnoylCoA * C16EnoylCoAMAT * PMSred / (KeqvlcadC16 * KmvlcadC16AcylCoAMAT * KmvlcadPMSox)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmvlcadC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmvlcadC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmvlcadC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmvlcadC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmvlcadC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmvlcadC14EnoylCoAMAT + pfC16AcylCoA * C16AcylCoAMAT / KmvlcadC16AcylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmvlcadC16EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmvlcadC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmvlcadC8EnoylCoAMAT) * (1 + PMSox / KmvlcadPMSox + PMSred / KmvlcadPMSred))
vvlcadC8 — PMSox + C8AcylCoAMAT = PMSred + C8EnoylCoAMAT

sfvlcadC8 * Vvlcad * (pfC8AcylCoA * C8AcylCoAMAT * PMSox / (KmvlcadC8AcylCoAMAT * KmvlcadPMSox) - pfC8EnoylCoA * C8EnoylCoAMAT * PMSred / (KeqvlcadC8 * KmvlcadC8AcylCoAMAT * KmvlcadPMSox)) / ((1 + pfC10AcylCoA * C10AcylCoAMAT / KmvlcadC10AcylCoAMAT + pfC10EnoylCoA * C10EnoylCoAMAT / KmvlcadC10EnoylCoAMAT + pfC12AcylCoA * C12AcylCoAMAT / KmvlcadC12AcylCoAMAT + pfC12EnoylCoA * C12EnoylCoAMAT / KmvlcadC12EnoylCoAMAT + pfC14AcylCoA * C14AcylCoAMAT / KmvlcadC14AcylCoAMAT + pfC14EnoylCoA * C14EnoylCoAMAT / KmvlcadC14EnoylCoAMAT + pfC16AcylCoA * C16AcylCoAMAT / KmvlcadC16AcylCoAMAT + pfC16EnoylCoA * C16EnoylCoAMAT / KmvlcadC16EnoylCoAMAT + pfC8AcylCoA * C8AcylCoAMAT / KmvlcadC8AcylCoAMAT + pfC8EnoylCoA * C8EnoylCoAMAT / KmvlcadC8EnoylCoAMAT) * (1 + PMSox / KmvlcadPMSox + PMSred / KmvlcadPMSred))

Parameters 0   380

Global parameters

Id Value
C2AcylCarMAT 0.0
CarMAT 0.0263853759485
CarMATt 0.0263853759485
CoAMAT 30.0145987583
CoAMATt 30.0145987583
CoASHseq 2300.0
KeqcactC10 1.0
KeqcactC12 1.0
KeqcactC14 1.0
KeqcactC16 1.0
KeqcactC4 1.0
KeqcactC6 1.0
KeqcactC8 1.0
Keqcpt1C10 0.473
Keqcpt1C12 0.473
Keqcpt1C14 0.473
Keqcpt1C16 0.473
Keqcpt1C8 0.473
Keqcpt2C10 1.928
Keqcpt2C12 1.928
Keqcpt2C14 1.928
Keqcpt2C16 1.928
Keqcpt2C4 1.928
Keqcpt2C6 1.928
Keqcpt2C8 1.928
KeqcratC10 0.519
KeqcratC4 0.519
KeqcratC6 0.519
KeqcratC8 0.519
KeqcrotC10 1.33
KeqcrotC12 1.33
KeqcrotC14 1.33
KeqcrotC16 1.33
KeqcrotC4 5.21
KeqcrotC6 1.49
KeqcrotC8 1.33
KeqmcadC10 8.27
KeqmcadC12 8.27
KeqmcadC14 8.27
KeqmcadC16 8.27
KeqmcadC4 0.728
KeqmcadC6 0.728
KeqmcadC8 8.27
KeqmckatC10 249000.0
KeqmckatC12 249000.0
KeqmckatC14 249000.0
KeqmckatC16 249000.0
KeqmckatC4 23400.0
KeqmckatC6 699000.0
KeqmckatC8 249000.0
KeqmschadC10 0.00388
KeqmschadC12 0.00388
KeqmschadC14 0.00388
KeqmschadC16 0.00388
KeqmschadC4 0.00767
KeqmschadC6 0.000825
KeqmschadC8 0.00388
KeqmtpC10 1280.0
KeqmtpC12 1280.0
KeqmtpC14 1280.0
KeqmtpC16 1280.0
KeqmtpC6 840.0
KeqmtpC8 1280.0
KeqscadC4 0.728
KeqscadC6 0.728
KeqvlcadC10 8.27
KeqvlcadC12 8.27
KeqvlcadC14 8.27
KeqvlcadC16 8.27
KeqvlcadC8 8.27
Ki1cratC12AcylCoAMAT 3.4
Ki1cratC14AcylCoAMAT 1.5
Ki1cratC16AcylCoAMAT 0.43
Ki2cratC10AcylCoAMAT 12.0
Ki2cratC12AcylCoAMAT 10.0
Ki2cratC14AcylCoAMAT 4.2
Ki2cratC16AcylCoAMAT 8.0
KiacotcsCoAMAT 9.0
Kicpt2CarMAT 1486.0
KicrotC4KetoacylCoA 14.0
KmacotciC10AcylCoAMAT 16.0
KmacotciC12AcylCoAMAT 5.0
KmacotciC14AcylCoAMAT 3.0
KmacotciC16AcylCoAMAT 6.0
KmacotcsC10AcylCoAMAT 4.9
KmacotcsC12AcylCoAMAT 5.0
KmacotcsC14AcylCoAMAT 9.0
KmacotcsC16AcylCoAMAT 16.0
KmacotcsC4AcylCoAMAT 26.7
KmacotcsC6AcylCoAMAT 18.2
KmacotcsC8AcylCoAMAT 26.0
KmcactC10AcylCarMAT 15.0
KmcactC12AcylCarMAT 15.0
KmcactC14AcylCarMAT 15.0
KmcactC16AcylCarMAT 15.0
KmcactC2AcylCarMAT 15.0
KmcactC4AcylCarMAT 15.0
KmcactC6AcylCarMAT 15.0
KmcactC8AcylCarMAT 15.0
KmcactCarMAT 130.0
Kmcpt2C10AcylCarMAT 100.0
Kmcpt2C10AcylCoAMAT 16.7
Kmcpt2C10CarMAT 1000.0
Kmcpt2C12AcylCarMAT 91.0
Kmcpt2C12AcylCoAMAT 11.0
Kmcpt2C12CarMAT 400.0
Kmcpt2C14AcylCarMAT 42.0
Kmcpt2C14AcylCoAMAT 30.8
Kmcpt2C14CarMAT 593.0
Kmcpt2C16AcylCarMAT 67.0
Kmcpt2C16AcylCoAMAT 12.2
Kmcpt2C16CarMAT 386.0
Kmcpt2C4AcylCarMAT 5000.0
Kmcpt2C4AcylCoAMAT 300.0
Kmcpt2C4CarMAT 8000.0
Kmcpt2C6AcylCarMAT 2000.0
Kmcpt2C6AcylCoAMAT 151.5
Kmcpt2C6CarMAT 8000.0
Kmcpt2C8AcylCarMAT 1180.0
Kmcpt2C8AcylCoAMAT 22.9
Kmcpt2C8CarMAT 5014.0
Kmcpt2CoAMAT 1400.0
KmcratC10AcylCarMAT 670.0
KmcratC10AcylCoAMAT 64.0
KmcratC2AcylCarMAT 660.0
KmcratC2AcylCoAMAT 21.3
KmcratC4AcylCarMAT 600.0
KmcratC4AcylCoAMAT 43.5
KmcratC6AcylCarMAT 2510.0
KmcratC6AcylCoAMAT 54.9
KmcratC8AcylCarMAT 1270.0
KmcratC8AcylCoAMAT 50.3
KmcratCarMAT 130.0
KmcratCoAMAT 88.8
KmcrotC10EnoylCoAMAT 7.0
KmcrotC10HydroxyacylCoAMAT 0.35
KmcrotC12EnoylCoAMAT 5.0
KmcrotC12HydroxyacylCoAMAT 0.35
KmcrotC14EnoylCoAMAT 5.0
KmcrotC14HydroxyacylCoAMAT 0.35
KmcrotC16EnoylCoAMAT 5.0
KmcrotC16HydroxyacylCoAMAT 0.35
KmcrotC4EnoylCoAMAT 30.0
KmcrotC4HydroxyacylCoAMAT 37.0
KmcrotC6EnoylCoAMAT 15.0
KmcrotC6HydroxyacylCoAMAT 18.68
KmcrotC8EnoylCoAMAT 9.0
KmcrotC8HydroxyacylCoAMAT 0.35
KmmcadC10AcylCoAMAT 9.1
KmmcadC10EnoylCoAMAT 0.153
KmmcadC12AcylCoAMAT 9.3
KmmcadC12EnoylCoAMAT 0.153
KmmcadC14AcylCoAMAT 10.0
KmmcadC14EnoylCoAMAT 0.153
KmmcadC16AcylCoAMAT 23.8
KmmcadC16EnoylCoAMAT 0.153
KmmcadC4AcylCoAMAT 71.5
KmmcadC4EnoylCoAMAT 0.153
KmmcadC6AcylCoAMAT 21.6
KmmcadC6EnoylCoAMAT 0.153
KmmcadC8AcylCoAMAT 8.0
KmmcadC8EnoylCoAMAT 0.153
KmmcadETFox 3.4
KmmcadETFred 24.2
KmmcadPMSox 1620.0
KmmcadPMSred 1620.0
KmmckatAcetylCoAMAT 250.0
KmmckatC10AcylCoAMAT 497.2
KmmckatC10CoAMAT 35.7
KmmckatC10KetoacylCoAMAT 2.1
KmmckatC12AcylCoAMAT 400.4
KmmckatC12CoAMAT 38.4
KmmckatC12KetoacylCoAMAT 1.3
KmmckatC14AcylCoAMAT 313.3
KmmckatC14CoAMAT 33.5
KmmckatC14KetoacylCoAMAT 1.2
KmmckatC16CoAMAT 28.6
KmmckatC16KetoacylCoAMAT 1.1
KmmckatC2AcylCoAMAT 25.5
KmmckatC4AcylCoAMAT 3540.6
KmmckatC4CoAMAT 2.2
KmmckatC4KetoacylCoAMAT 12.4
KmmckatC6AcylCoAMAT 1131.5
KmmckatC6CoAMAT 18.9
KmmckatC6KetoacylCoAMAT 6.7
KmmckatC8AcylCoAMAT 746.7
KmmckatC8CoAMAT 35.5
KmmckatC8KetoacylCoAMAT 3.2
KmmschadC10HydroxyacylCoAMAT 1.9
KmmschadC10KetoacylCoAMAT 2.3
KmmschadC12HydroxyacylCoAMAT 1.8
KmmschadC12KetoacylCoAMAT 1.8
KmmschadC14HydroxyacylCoAMAT 1.5
KmmschadC14KetoacylCoAMAT 1.3
KmmschadC16HydroxyacylCoAMAT 1.5
KmmschadC16KetoacylCoAMAT 1.3
KmmschadC4HydroxyacylCoAMAT 75.0
KmmschadC4KetoacylCoAMAT 13.8
KmmschadC6HydroxyacylCoAMAT 15.0
KmmschadC6KetoacylCoAMAT 5.7
KmmschadC8HydroxyacylCoAMAT 1.9
KmmschadC8KetoacylCoAMAT 3.1
KmmschadNADHMAT 0.93
KmmschadNADMAT 34.2
KmmtpAcetylCoAMAT 250.0
KmmtpC10AcylCoAMAT 20020.1
KmmtpC10CoAMAT 35.7
KmmtpC10EnoylCoAMAT 102.05
KmmtpC12AcylCoAMAT 14627.7
KmmtpC12CoAMAT 38.4
KmmtpC12EnoylCoAMAT 102.05
KmmtpC14AcylCoAMAT 12288.1
KmmtpC14CoAMAT 33.5
KmmtpC14EnoylCoAMAT 102.05
KmmtpC16CoAMAT 28.6
KmmtpC16EnoylCoAMAT 110.0
KmmtpC4AcylCoAMAT 33931.3
KmmtpC6AcylCoAMAT 22703.3
KmmtpC6CoAMAT 18.9
KmmtpC6EnoylCoAMAT 102.05
KmmtpC8AcylCoAMAT 19550.9
KmmtpC8CoAMAT 35.5
KmmtpC8EnoylCoAMAT 102.05
KmmtpNADHMAT 50.0
KmmtpNADMAT 60.0
KmscadC4AcylCoAMAT 0.38
KmscadC4EnoylCoAMAT 0.5
KmscadC6AcylCoAMAT 4.4
KmscadC6EnoylCoAMAT 0.5
KmscadETFox 4.1
KmscadETFred 24.2
KmscadPMSox 176.0
KmscadPMSred 176.0
KmvlcadC10AcylCoAMAT 10.0
KmvlcadC10EnoylCoAMAT 0.377
KmvlcadC12AcylCoAMAT 7.0
KmvlcadC12EnoylCoAMAT 0.377
KmvlcadC14AcylCoAMAT 10.0
KmvlcadC14EnoylCoAMAT 0.377
KmvlcadC16AcylCoAMAT 14.0
KmvlcadC16EnoylCoAMAT 0.377
KmvlcadC8AcylCoAMAT 8.0
KmvlcadC8EnoylCoAMAT 0.377
KmvlcadETFox 0.83
KmvlcadETFred 24.2
KmvlcadPMSox 1620.0
KmvlcadPMSred 1620.0
NADoxVSred 7.5
NADtMAT 250.0
OctCoA 0.0
PalCoA 30.0
Vacotci 0.001
Vacotcs 0.002
Vcpt1 0.872
Vcpt2 0.28
Vcrat 0.06
Vcrot 10.0
Vfcact 2.34
Vmcad 0.038
Vmckat 2.98
Vmschad 2.31
Vmtp 0.1656
Vrcact 2.34
Vscad 0.01668
Vvlcad 0.076
contactSiteCPT 0.4
mcad 1.0
pfC10AcylCar 1.0
pfC10AcylCoA 1.0
pfC10EnoylCoA 1.0
pfC10HydroxyacylCoA 1.0
pfC10KetoacylCoA 1.0
pfC12AcylCar 1.0
pfC12AcylCoA 1.0
pfC12EnoylCoA 1.0
pfC12HydroxyacylCoA 1.0
pfC12KetoacylCoA 1.0
pfC14AcylCar 1.0
pfC14AcylCoA 1.0
pfC14EnoylCoA 1.0
pfC14HydroxyacylCoA 1.0
pfC14KetoacylCoA 1.0
pfC16AcylCar 1.0
pfC16AcylCoA 1.0
pfC16EnoylCoA 1.0
pfC16HydroxyacylCoA 1.0
pfC16KetoacylCoA 1.0
pfC2AcylCar 1.0
pfC2AcylCoA 1.0
pfC4AcylCar 1.0
pfC4AcylCoA 1.0
pfC4EnoylCoA 1.0
pfC4HydroxyacylCoA 1.0
pfC4KetoacylCoA 1.0
pfC6AcylCar 1.0
pfC6AcylCoA 1.0
pfC6EnoylCoA 1.0
pfC6HydroxyacylCoA 1.0
pfC6KetoacylCoA 1.0
pfC8AcylCar 1.0
pfC8AcylCoA 1.0
pfC8EnoylCoA 1.0
pfC8HydroxyacylCoA 1.0
pfC8KetoacylCoA 1.0
sfacotciC10 0.8
sfacotciC12 0.8
sfacotciC14 0.99
sfacotciC16 1.0
sfacotcsC10 0.92
sfacotcsC12 0.93
sfacotcsC14 0.965
sfacotcsC16 1.0
sfacotcsC4 1.0
sfacotcsC6 0.47
sfacotcsC8 0.91
sfcactC10 1.0
sfcactC12 0.63
sfcactC14 0.63
sfcactC16 0.63
sfcactC4 0.87
sfcactC6 1.0
sfcactC8 1.0
sfcpt1C10 0.81
sfcpt1C12 2.72
sfcpt1C14 1.29
sfcpt1C16 1.0
sfcpt1C8 1.74
sfcpt2C10 0.7
sfcpt2C12 1.26
sfcpt2C14 0.66
sfcpt2C16 1.0
sfcpt2C4 0.01
sfcpt2C6 0.16
sfcpt2C8 1.07
sfcratC10 0.33
sfcratC4 1.0
sfcratC6 1.2
sfcratC8 0.5
sfcrotC10 0.16
sfcrotC12 0.091
sfcrotC14 0.065
sfcrotC16 0.01
sfcrotC4 1.0
sfcrotC6 0.23
sfcrotC8 0.17
sfmcadC10 0.59
sfmcadC12 0.58
sfmcadC14 0.22
sfmcadC16 0.17
sfmcadC4 0.2
sfmcadC6 1.05
sfmcadC8 1.0
sfmckatC10 1.33
sfmckatC12 0.78
sfmckatC14 0.41
sfmckatC16 0.0
sfmckatC4 1.0
sfmckatC6 2.04
sfmckatC8 1.65
sfmschadC10 0.55
sfmschadC12 0.6
sfmschadC14 0.575
sfmschadC16 0.5
sfmschadC4 1.0
sfmschadC6 0.95
sfmschadC8 0.55
sfmtpC10 0.81
sfmtpC12 0.93
sfmtpC14 0.97
sfmtpC16 1.0
sfmtpC6 0.34
sfmtpC8 0.68
sfscadC4 1.0
sfscadC6 0.542
sfvlcadC10 0.2
sfvlcadC12 0.2
sfvlcadC14 0.511
sfvlcadC16 1.0
sfvlcadC8 0.1
vlcad 1.0

Local parameters

Id Value Reaction

Rules 0   0   4

Assignment rules

Definition
CarMAT = -C2AcylCarMAT + CarMATt - C10AcylCarMAT - C12AcylCarMAT - C14AcylCarMAT - C16AcylCarMAT - C4AcylCarMAT - C6AcylCarMAT - C8AcylCarMAT
CoAMAT = CoAMATt - CoASHseq - C10AcylCoAMAT - C10EnoylCoAMAT - C10HydroxyacylCoAMAT - C10KetoacylCoAMAT - C12AcylCoAMAT - C12EnoylCoAMAT - C12HydroxyacylCoAMAT - C12KetoacylCoAMAT - C14AcylCoAMAT - C14EnoylCoAMAT - C14HydroxyacylCoAMAT - C14KetoacylCoAMAT - C16AcylCoAMAT - C16EnoylCoAMAT - C16HydroxyacylCoAMAT - C16KetoacylCoAMAT - C2AcylCoAMAT - C4AcylCoAMAT - C4EnoylCoAMAT - C4HydroxyacylCoAMAT - C4KetoacylCoAMAT - C6AcylCoAMAT - C6EnoylCoAMAT - C6HydroxyacylCoAMAT - C6KetoacylCoAMAT - C8AcylCoAMAT - C8EnoylCoAMAT - C8HydroxyacylCoAMAT - C8KetoacylCoAMAT
Vmcad = 0.038 * mcad
Vvlcad = 0.076 * vlcad

Rate rules

Definition

Algebraic rules

Definition

Events 0

Trigger Assignments