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Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: equations and parameter refinement
Peter J. MULQUINEY and Philip W. KUCHEL
Department of Biochemistry, University of Sydney, Sydney, NSW 2006, Australia
Over the last 25 years, several mathematical models of erythrocyte metabolism have been developed. Although these models have identified the key features in the regulation and control of erythrocyte metabolism, many important aspects remain un- explained. In particular, none of these models have satisfactorily accounted for 2,3-bisphosphoglycerate (2,3-BPG) metabolism. 2,3-BPG is an important modulator of haemoglobin oxygen affinity, and hence an understanding of the regulation of 2,3- BPG concentration is important for understanding blood oxygen transport. A detailed, comprehensive, and hence realistic math- ematical model of erythrocyte metabolism is presented that can explain the regulation and control of 2,3-BPG concentration and turnover. The model is restricted to the core metabolic pathways, namely glycolysis, the 2,3-BPG shunt and the pentose phosphate pathway (PPP), and includes membrane transport of metabolites, the binding of metabolites to haemoglobin and Mg5+, as well as pH effects on key enzymic reactions and binding processes. The model is necessarily complex, since it is intended to describe the regulation and control of 2,3-BPG metabolism under a wide variety of physiological and experimental conditions. In addition, since H+ and blood oxygen tension are important external effectors of 2,3-BPG concentration, it was important that the model take into account the large array of kinetic and binding phenomena that result from changes in these effectors. Through an iterative loop of experimental and simulation analysis many values of enzyme-kinetic parameters of the model were refined to yield close conformity between model simulations and ‘ real ’ experimental data. This iterative process enabled a single set of parameters to be found which described well the metabolic behaviour of the erythrocyte under a wide variety of conditions.
Biochem. J. (1999) 342, 581–596
Unit definitions have no effect on the numerical analysis of the model. It remains the responsibility of the modeler to ensure the internal numerical consistency of the model. If units are provided, however, the consistency of the model units will be checked.
| Name | Definition | |
|---|---|---|
| — | 1.0 mole | |
| — | 1.0 mole litre^(-1.0) | |
| — | 1.0 second | |
| — | 1.0 litre |
| Id | Name | Spatial dimensions | Size | |
|---|---|---|---|---|
| compartment | compartment | 3.0 | 1.0 L |
| Id | Name | Initial quantity | Compartment | Fixed | |
|---|---|---|---|---|---|
| ADP | ADP | 0.00031 mole/L | compartment (compartment) | ✘ | |
| AMP | AMP | 3e-05 mole/L | compartment (compartment) | ✘ | |
| ATP | ATP | 0.0021 mole/L | compartment (compartment) | ✘ | |
| B13PG | B13PG | 7e-07 mole/L | compartment (compartment) | ✘ | |
| B23PG | B23PG | 0.0067 mole/L | compartment (compartment) | ✘ | |
| BPGSP | BPGSP | 3.8e-06 mole/L | compartment (compartment) | ✘ | |
| BPGSPB13PG | BPGSPB13PG | 0.0 mole/L | compartment (compartment) | ✘ | |
| BPGSPB23PG | BPGSPB23PG | 0.0 mole/L | compartment (compartment) | ✘ | |
| BPGSPP | BPGSPP | 0.0 mole/L | compartment (compartment) | ✘ | |
| BPGSPPP2GA | BPGSPPP2GA | 0.0 mole/L | compartment (compartment) | ✘ | |
| BPGSPPP3GA | BPGSPPP3GA | 0.0 mole/L | compartment (compartment) | ✘ | |
| BPGSPPPhos | BPGSPPPhos | 0.0 mole/L | compartment (compartment) | ✘ | |
| CO2 | CO2 | 0.0012 mole/L | compartment (compartment) | ✔ | |
| Ery4P | Ery4P | 1e-05 mole/L | compartment (compartment) | ✘ | |
| Fru16P2 | Fru16P2 | 2.7e-06 mole/L | compartment (compartment) | ✘ | |
| Fru6P | Fru6P | 1.3e-05 mole/L | compartment (compartment) | ✘ | |
| GSH | GSH | 0.0032 mole/L | compartment (compartment) | ✘ | |
| GSSG | GSSG | 9e-08 mole/L | compartment (compartment) | ✘ | |
| Glc | Glc | 0.005 mole/L | compartment (compartment) | ✔ | |
| Glc16P2 | Glc16P2 | 0.000122 mole/L | compartment (compartment) | ✘ | |
| Glc6P | Glc6P | 4e-05 mole/L | compartment (compartment) | ✘ | |
| GraP | GraP | 5.7e-06 mole/L | compartment (compartment) | ✘ | |
| GrnP | GrnP | 1.9e-05 mole/L | compartment (compartment) | ✘ | |
| Hb | Hb | 0.007 mole/L | compartment (compartment) | ✘ | |
| HbADP | HbADP | 0.0 mole/L | compartment (compartment) | ✘ | |
| HbATP | HbATP | 0.0 mole/L | compartment (compartment) | ✘ | |
| HbB13PG | HbB13PG | 0.0 mole/L | compartment (compartment) | ✘ | |
| HbB23PG | HbB23PG | 0.0 mole/L | compartment (compartment) | ✘ | |
| HbMgATP | HbMgATP | 0.0 mole/L | compartment (compartment) | ✘ | |
| Lac | Lac | 0.0014 mole/L | compartment (compartment) | ✘ | |
| Lace | Lace | 0.00182 mole/L | compartment (compartment) | ✔ | |
| Mg | Mg | 0.003 mole/L | compartment (compartment) | ✘ | |
| MgADP | MgADP | 0.0 mole/L | compartment (compartment) | ✘ | |
| MgATP | MgATP | 0.0 mole/L | compartment (compartment) | ✘ | |
| MgB13PG | MgB13PG | 0.0 mole/L | compartment (compartment) | ✘ | |
| MgB23PG | MgB23PG | 0.0 mole/L | compartment (compartment) | ✘ | |
| MgFru16P2 | MgFru16P2 | 0.0 mole/L | compartment (compartment) | ✘ | |
| MgGlc16P2 | MgGlc16P2 | 0.0 mole/L | compartment (compartment) | ✘ | |
| MgPhos | MgPhos | 0.0 mole/L | compartment (compartment) | ✘ | |
| NAD | NAD | 6e-05 mole/L | compartment (compartment) | ✘ | |
| NADH | NADH | 1.4e-07 mole/L | compartment (compartment) | ✘ | |
| NADP | NADP | 1.25e-07 mole/L | compartment (compartment) | ✘ | |
| NADPH | NADPH | 6.4e-05 mole/L | compartment (compartment) | ✘ | |
| P2GA | P2GA | 1e-05 mole/L | compartment (compartment) | ✘ | |
| P3GA | P3GA | 6.4e-05 mole/L | compartment (compartment) | ✘ | |
| P6G | P6G | 1.4e-07 mole/L | compartment (compartment) | ✘ | |
| P6GL | P6GL | 1.4e-10 mole/L | compartment (compartment) | ✘ | |
| PEP | PEP | 2.3e-05 mole/L | compartment (compartment) | ✘ | |
| Phos | Phos | 0.001 mole/L | compartment (compartment) | ✘ | |
| Phose | Phose | 0.00192 mole/L | compartment (compartment) | ✔ | |
| Pyr | Pyr | 6e-05 mole/L | compartment (compartment) | ✘ | |
| Pyre | Pyre | 8.5e-05 mole/L | compartment (compartment) | ✔ | |
| Rib5P | Rib5P | 1e-05 mole/L | compartment (compartment) | ✘ | |
| Ru5P | Ru5P | 1e-05 mole/L | compartment (compartment) | ✘ | |
| Sed7P | Sed7P | 1e-05 mole/L | compartment (compartment) | ✘ | |
| TK | TK | 3.3e-07 mole/L | compartment (compartment) | ✘ | |
| TKG | TKG | 0.0 mole/L | compartment (compartment) | ✘ | |
| TKGEry4P | TKGEry4P | 0.0 mole/L | compartment (compartment) | ✘ | |
| TKGRib5P | TKGRib5P | 0.0 mole/L | compartment (compartment) | ✘ | |
| TKXu5P | TKXu5P | 0.0 mole/L | compartment (compartment) | ✘ | |
| Xu5P | Xu5P | 1e-06 mole/L | compartment (compartment) | ✘ |
Initial assignments are expressions that are evaluated at time=0. It is not recommended to create initial assignments for all model entities. Restrict the use of initial assignments to cases where a value is expressed in terms of values or sizes of other model entities. Note that it is not permitted to have both an initial assignment and an assignment rule for a single model entity.
| Definition |
|---|
| Id | Name | Objective coefficient | Reaction Equation and Kinetic Law | Flux bounds | |
|---|---|---|---|---|---|
| vak | vak | MgADP + ADP = MgATP + AMP 4300 * (1 + Khadp / pow(10, pH1) + Kkadp * k1) * ADP * MgADP - 1400 * (1 + Khamp / pow(10, pH1) + Kkamp * k1) * AMP * MgATP | |||
| vald | vald | Fru16P2 = GrnP + GraP VALD * (Fru16P2 * kcatfald / Kmaldfru16p2 - GraP * GrnP * kcatrald / (Kialdgrnp * Kmaldgrap)) / (1 + GrnP / Kialdgrnp + Fru16P2 / Kmaldfru16p2 + GraP * GrnP / (Kialdgrnp * Kmaldgrap) + Fru16P2 * GraP * Kmaldgrnp / (Kialdfru16p2 * Kialdgrnp * Kmaldgrap) + (B23PG + MgB23PG) / Kialdb23pg + GraP * Kmaldgrnp * (1 + (B23PG + MgB23PG) / Kialdb23pg) / (Kialdgrnp * Kmaldgrap)) | |||
| vatpase | vatpase | MgATP = MgADP + Phos katpase * MgATP | |||
| vbpgsp1 | vbpgsp1 | B13PG + BPGSP = BPGSPB13PG 2.80950914520767 * pow(10, 8) * B13PG * BPGSP / (1 + 1.58489319246111 * pow(10, -7) * pow(10, pH1)) - kbpgsp2 * BPGSPB13PG | |||
| vbpgsp2 | vbpgsp2 | BPGSPB13PG = BPGSPP + P3GA 17.4099179927889 * BPGSPB13PG / (1 + 4.78630092322638 * pow(10, 28) / pow(10, 4 * pH1)) | |||
| vbpgsp3 | vbpgsp3 | BPGSPP + P3GA = BPGSPPP3GA -kbpgsp5 * BPGSPPP3GA + 3.25336851380399 * pow(10, 8) * BPGSPP * P3GA / (1 + 4.78630092322638 * pow(10, 28) / pow(10, 4 * pH1)) | |||
| vbpgsp4 | vbpgsp4 | BPGSPP + P2GA = BPGSPPP2GA -kbpgsp7 * BPGSPPP2GA + 1758.57757502918 * BPGSPP * P2GA / (1 + 4.78630092322638 * pow(10, 28) / pow(10, 4 * pH1)) | |||
| vbpgsp5 | vbpgsp5 | BPGSPPP3GA = BPGSPB23PG kbpgsp8 * BPGSPPP3GA - kbpgsp9 * BPGSPB23PG | |||
| vbpgsp6 | vbpgsp6 | BPGSPPP2GA = BPGSPB23PG kbpgsp10 * BPGSPPP2GA - kbpgsp11 * BPGSPB23PG | |||
| vbpgsp7 | vbpgsp7 | BPGSPB23PG = BPGSP + B23PG -(6.32139557671725 * pow(10, 6) * B23PG * BPGSP / (1 + 1.58489319246111 * pow(10, -7) * pow(10, pH1))) + kbpgsp12 * BPGSPB23PG | |||
| vbpgsp8 | vbpgsp8 | BPGSPP + Phos = BPGSPPPhos kbpgsp14 * BPGSPP * Phos - kbpgsp15 * BPGSPPPhos | |||
| vbpgsp9 | vbpgsp9 | BPGSPPPhos = BPGSP + {2.0}Phos kbpgsp16 * BPGSPPPhos | |||
| veno | veno | P2GA = PEP VENO * (kcatfeno * Mg * P2GA / (Kienomg * Kmenop2ga) - kcatreno * Mg * PEP / (Kienopep * Kmenomg)) / (1 + Mg / Kienomg + P2GA / Kienop2ga + Mg * P2GA / (Kienomg * Kmenop2ga) + PEP / Kienopep + Mg * PEP / (Kienopep * Kmenomg)) | |||
| vg6pdh | vg6pdh | Glc6P + NADP = P6GL + NADPH VG6PDH * (Glc6P * kg6pdh1 * kg6pdh3 * kg6pdh5 * kg6pdh7 * kg6pdh9 * NADP - kg6pdh2 * kg6pdh4 * kg6pdh6 * kg6pdh8 * kg6pdh10 * NADPH * P6GL) / (Glc6P * kg6pdh3 * kg6pdh5 * kg6pdh7 * kg6pdh9 + kg6pdh2 * (kg6pdh4 * kg6pdh6 + kg6pdh4 * kg6pdh7 + kg6pdh5 * kg6pdh7) * kg6pdh9 + kg6pdh1 * (kg6pdh4 * kg6pdh6 + kg6pdh4 * kg6pdh7 + kg6pdh5 * kg6pdh7) * kg6pdh9 * NADP + Glc6P * kg6pdh1 * kg6pdh3 * (kg6pdh5 * kg6pdh7 + kg6pdh5 * kg6pdh9 + kg6pdh6 * kg6pdh9 + kg6pdh7 * kg6pdh9) * NADP + Glc6P * kg6pdh3 * kg6pdh5 * kg6pdh7 * kg6pdh10 * NADPH + kg6pdh2 * (kg6pdh4 * kg6pdh6 + kg6pdh5 * kg6pdh6 + kg6pdh5 * kg6pdh7) * kg6pdh10 * NADPH + kg6pdh2 * kg6pdh4 * kg6pdh6 * kg6pdh8 * P6GL + kg6pdh1 * kg6pdh4 * kg6pdh6 * kg6pdh8 * NADP * P6GL + Glc6P * kg6pdh1 * kg6pdh3 * (kg6pdh5 + kg6pdh6) * kg6pdh8 * NADP * P6GL + Glc6P * kg6pdh3 * (kg6pdh5 + kg6pdh6) * kg6pdh8 * kg6pdh10 * NADPH * P6GL + (kg6pdh2 * kg6pdh4 + kg6pdh2 * kg6pdh5 + kg6pdh2 * kg6pdh6 + kg6pdh4 * kg6pdh6) * kg6pdh8 * kg6pdh10 * NADPH * P6GL) | |||
| vgapdh | vgapdh | GraP + Phos + NAD = B13PG + NADH VGDH * (-5.40304497429925 * pow(10, 35) * B13PG * NADH / pow(10, pH1) + 1.45911949685535 * pow(10, 21) * GraP * NAD * Phos / (Kigapdhphos * Kmgapdhnad)) / (2.19517763377412 * pow(10, 20) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * B13PG * (1 + GraP / Kidgapdhgrap) + 2.0985345932935 * pow(10, 18) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * GraP * (1 + GraP / Kidgapdhgrap) + 1 / Kigapdhnad * 2.19517763377412 * pow(10, 20) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * B13PG * NAD + 1 / Kigapdhnad * 2.0985345932935 * pow(10, 18) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * GraP * NAD + 1.05427942060955 * pow(10, 33) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * Kmgapdhb13pg * NADH / pow(10, pH1) + 1.05427942060955 * pow(10, 33) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * B13PG * NADH / pow(10, pH1) + 3.32595319105503 * pow(10, 30) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * GraP * NADH / pow(10, pH1) + 1 / Kigapdhphos * 2.0985345932935 * pow(10, 18) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * GraP * (1 + GraP / Kidgapdhgrap) * Phos + 2.0985345932935 * pow(10, 18) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * Kmgapdhgrap * NAD * Phos / (Kigapdhphos * Kmgapdhnad) + 2.0985345932935 * pow(10, 18) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * Kmgapdhgrap * B13PG * NAD * Phos / (Kidgapdhb13pg * Kigapdhphos * Kmgapdhnad) + 2.0985345932935 * pow(10, 18) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * GraP * NAD * Phos / (Kigapdhphos * Kmgapdhnad) + 1 / Kigapdhphos * (1.05427942060955 * pow(10, 33) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * Kmgapdhb13pg * NADH * Phos / pow(10, pH1)) + 1.05427942060955 * pow(10, 33) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * Kmgapdhb13pg * B13PG * NADH * Phos / pow(10, pH1) / (Kidgapdhb13pg * Kigapdhphos) + 1 / Kigapdhphos * (3.32595319105503 * pow(10, 30) * (1 + 3.16227766016838 * pow(10, 7) / pow(10, pH1) + 1 * pow(10, -10) * pow(10, pH1)) * GraP * NADH * Phos / pow(10, pH1))) | |||
| vgpi | vgpi | Glc6P = Fru6P VGPI * (-(Fru6P * kcatrgpi / Kmgpifru6p) + Glc6P * kcatfgpi / Kmgpiglc6p) / (1 + Fru6P / Kmgpifru6p + Glc6P / Kmgpiglc6p) | |||
| vgssgr | vgssgr | NADPH + GSSG = NADP + {2.0}GSH VGSSGR * (-(GSH^2) * kgssgr2 * kgssgr4 * kgssgr6 * kgssgr8 * kgssgr10 * kgssgr12 * NADP + GSSG * kgssgr1 * kgssgr3 * kgssgr5 * kgssgr7 * kgssgr9 * kgssgr11 * NADPH) / (GSH^2 * kgssgr2 * kgssgr4 * kgssgr6 * kgssgr8 * kgssgr10 + GSH * kgssgr2 * kgssgr4 * kgssgr6 * kgssgr8 * kgssgr11 + GSSG * kgssgr3 * kgssgr5 * kgssgr7 * kgssgr9 * kgssgr11 + kgssgr2 * (kgssgr4 * kgssgr6 + kgssgr4 * kgssgr7 + kgssgr5 * kgssgr7) * kgssgr9 * kgssgr11 + GSH * kgssgr2 * kgssgr4 * kgssgr6 * kgssgr8 * kgssgr12 * NADP + GSSG * kgssgr3 * kgssgr5 * kgssgr7 * kgssgr9 * kgssgr12 * NADP + kgssgr2 * (kgssgr4 * kgssgr6 + kgssgr4 * kgssgr7 + kgssgr5 * kgssgr7) * kgssgr9 * kgssgr12 * NADP + GSH * GSSG * kgssgr3 * kgssgr5 * kgssgr7 * kgssgr10 * kgssgr12 * NADP + GSH * kgssgr2 * (kgssgr4 * kgssgr6 + kgssgr4 * kgssgr7 + kgssgr5 * kgssgr7) * kgssgr10 * kgssgr12 * NADP + GSH^2 * GSSG * kgssgr3 * (kgssgr5 + kgssgr6) * kgssgr8 * kgssgr10 * kgssgr12 * NADP + GSH^2 * (kgssgr2 * kgssgr4 + kgssgr2 * kgssgr5 + kgssgr2 * kgssgr6 + kgssgr4 * kgssgr6) * kgssgr8 * kgssgr10 * kgssgr12 * NADP + GSH * GSSG * kgssgr1 * kgssgr3 * kgssgr5 * kgssgr7 * kgssgr10 * NADPH + GSH^2 * kgssgr1 * kgssgr4 * kgssgr6 * kgssgr8 * kgssgr10 * NADPH + GSH^2 * GSSG * kgssgr1 * kgssgr3 * (kgssgr5 + kgssgr6) * kgssgr8 * kgssgr10 * NADPH + GSH * kgssgr1 * kgssgr4 * kgssgr6 * kgssgr8 * kgssgr11 * NADPH + GSH * GSSG * kgssgr1 * kgssgr3 * (kgssgr5 + kgssgr6) * kgssgr8 * kgssgr11 * NADPH + kgssgr1 * (kgssgr4 * kgssgr6 + kgssgr4 * kgssgr7 + kgssgr5 * kgssgr7) * kgssgr9 * kgssgr11 * NADPH + GSSG * kgssgr1 * kgssgr3 * (kgssgr5 * kgssgr7 * kgssgr9 + kgssgr5 * kgssgr7 * kgssgr11 + kgssgr5 * kgssgr9 * kgssgr11 + kgssgr6 * kgssgr9 * kgssgr11 + kgssgr7 * kgssgr9 * kgssgr11) * NADPH) | |||
| vhbadp | vhbadp | Hb + ADP = HbADP -HbADP * khbadpd + 300000 * ADP * Hb * (1 + 3.16978638492223 * pow(10, 7) * Kahb + 2.51188643150958 * pow(10, 14) * pow(Kahb, 2)) / (1 + pow(2, 1 + pH1) * pow(5, pH1) * Kahb + pow(10, 2 * pH1) * pow(Kahb, 2)) | |||
| vhbatp | vhbatp | Hb + ATP = HbATP -HbATP * khbatpd + 432000 * ATP * Hb * (1 + 3.16978638492223 * pow(10, 7) * Kahb + 2.51188643150958 * pow(10, 14) * pow(Kahb, 2)) / (1 + pow(2, 1 + pH1) * pow(5, pH1) * Kahb + pow(10, 2 * pH1) * pow(Kahb, 2)) | |||
| vhbb13pg | vhbb13pg | Hb + B13PG = HbB13PG -HbB13PG * khbb13pgd + 380000 * B13PG * Hb * (1 + 3.16978638492223 * pow(10, 7) * Kahb + 2.51188643150958 * pow(10, 14) * pow(Kahb, 2)) / (1 + pow(2, 1 + pH1) * pow(5, pH1) * Kahb + pow(10, 2 * pH1) * pow(Kahb, 2)) | |||
| vhbbpg | vhbbpg | Hb + B23PG = HbB23PG -HbB23PG * khbbpgd + 300000 * B23PG * Hb * (1 + 3.16978638492223 * pow(10, 7) * Kahb + 2.51188643150958 * pow(10, 14) * pow(Kahb, 2)) / (1 + pow(2, 1 + pH1) * pow(5, pH1) * Kahb + pow(10, 2 * pH1) * pow(Kahb, 2)) | |||
| vhbmgatp | vhbmgatp | Hb + MgATP = HbMgATP -HbMgATP * khbmgatpd + 46800 * Hb * (1 + 3.16978638492223 * pow(10, 7) * Kahb + 2.51188643150958 * pow(10, 14) * pow(Kahb, 2)) * MgATP / (1 + pow(2, 1 + pH1) * pow(5, pH1) * Kahb + pow(10, 2 * pH1) * pow(Kahb, 2)) | |||
| vhk | vhk | Glc + MgATP = MgADP + Glc6P 2.85714 * VHK * Vi * (-(1.92792 * Glc6P * MgADP / ((1 + 1.0471285480509 * pow(10, 7) / pow(10, pH1) + 2.81838293126445 * pow(10, -10) * pow(10, pH1)) * Kihkglc6p * Kmhkmgadp)) + 299.16 * Glc * MgATP / ((1 + 1.0471285480509 * pow(10, 7) / pow(10, pH1) + 2.81838293126445 * pow(10, -10) * pow(10, pH1)) * Kihkglc * Kmhkmgatp)) / (1 + Glc / Kihkglc + Glc * B23PG / (Kdihkbpg * Kihkglc) + Glc * Glc16P2 / (Kdihkglc16p2 * Kihkglc) + Glc * Glc6P / (Kdihkglc6p * Kihkglc) + Glc6P / Kihkglc6p + Glc * GSH / (Kdihkgsh * Kihkglc) + MgADP / Kihkmgadp + Glc6P * MgADP / (Kihkglc6p * Kmhkmgadp) + MgATP / Kihkmgatp + Glc * MgATP / (Kihkglc * Kmhkmgatp)) | |||
| vlactransport | vlactransport | Lac = Lace 2.85714 * (-klactransporti * Lace * Ve + klactransporti * Ve * Lac / (1 + pow(10, -3.73 + pH1)) * (1 + pow(10, -3.73 + pH1) / rtv)) | |||
| vldh | vldh | Pyr + NADH = Lac + NAD VLDH * (-(1306.64221547056 * kcatrldh * Lac * NAD / ((1 + 6.30957344480193 * pow(10, 6) / pow(10, pH1)) * Kildhnad)) + 25634.207529267 * kcatfldh * NADH * Pyr / ((1 + 1.58489319246111 * pow(10, -7) * pow(10, pH1)) * Kildhnadh)) / (NAD / Kildhnad + 1306.64221547056 * Lac * NAD / ((1 + 6.30957344480193 * pow(10, 6) / pow(10, pH1)) * Kildhnad) + NADH / Kildhnadh + 1306.64221547056 * Kmldhnad * Lac * NADH / ((1 + 6.30957344480193 * pow(10, 6) / pow(10, pH1)) * Kildhnad * Kildhnadh) + 25634.207529267 * Kmldhnadh * NAD * Pyr / ((1 + 1.58489319246111 * pow(10, -7) * pow(10, pH1)) * Kildhnad * Kildhnadh) + 2.01262239795994 * pow(10, 7) * Lac * NAD * Pyr / ((1 + 6.30957344480193 * pow(10, 6) / pow(10, pH1)) * (1 + 1.58489319246111 * pow(10, -7) * pow(10, pH1)) * Kildhnad) + 25634.207529267 * NADH * Pyr / ((1 + 1.58489319246111 * pow(10, -7) * pow(10, pH1)) * Kildhnadh) + 4.88940918937581 * pow(10, 6) * Lac * NADH * Pyr / ((1 + 6.30957344480193 * pow(10, 6) / pow(10, pH1)) * (1 + 1.58489319246111 * pow(10, -7) * pow(10, pH1)) * Kildhnadh) + (1 + Pyr / Kidldhpyr) * (1 + 1306.64221547056 * Kmldhnad * Lac / ((1 + 6.30957344480193 * pow(10, 6) / pow(10, pH1)) * Kildhnad) + 25634.207529267 * Kmldhnadh * Pyr / ((1 + 1.58489319246111 * pow(10, -7) * pow(10, pH1)) * Kildhnadh))) | |||
| vldhp | vldhp | Pyr + NADPH = Lac + NADP (-(krldhp * Lac * NADP / Kmldhplac) + kfldhp * NADPH * Pyr / Kmldhppyr) / (1 + Lac / Kmldhplac + Pyr / Kmldhppyr) | |||
| vmgadp | vmgadp | Mg + ADP = MgADP 1711.2 * ADP * (Kmgadp + Khadp * Kmghadp / pow(10, pH1)) * Mg / (1 + Khadp / pow(10, pH1) + k1 * Kkadp) - kmgadpd * MgADP | |||
| vmgatp | vmgatp | ATP + Mg = MgATP 2620.8 * ATP * (Kmgatp + Khatp * Kmghatp / pow(10, pH1)) * Mg / (1 + Khatp / pow(10, pH1) + k1 * Kkatp) - kmgatpd * MgATP | |||
| vmgb13pg | vmgb13pg | Mg + B13PG = MgB13PG 729.6 * B13PG * (Kmgbpg + Khbpg * Kmghbpg / pow(10, pH1)) * Mg / (1 + Khbpg / pow(10, pH1) + Kh2bpg * Khbpg / pow(10, 2 * pH1) + k1 * Kkbpg + k1 * Khbpg * Kkhbpg / pow(10, pH1)) - kmgb13pgd * MgB13PG | |||
| vmgb23pg | vmgb23pg | Mg + B23PG = MgB23PG 2572.8 * B23PG * (Kmgbpg + Khbpg * Kmghbpg / pow(10, pH1)) * Mg / (1 + Khbpg / pow(10, pH1) + Kh2bpg * Khbpg / pow(10, 2 * pH1) + k1 * Kkbpg + k1 * Khbpg * Kkhbpg / pow(10, pH1)) - kmgbpgd * MgB23PG | |||
| vmgfru16p2 | vmgfru16p2 | Mg + Fru16P2 = MgFru16P2 3984 * Fru16P2 * (Kmgfru16p2 + Khf * Kmghf / pow(10, pH1)) * Mg / (1 + Khf / pow(10, pH1) + Kh2f * Khf / pow(10, 2 * pH1) + k1 * Kkf + k1 * Khf * Kkhf / pow(10, pH1)) - kmgf16p2d * MgFru16P2 | |||
| vmgglc16p2 | vmgglc16p2 | Mg + Glc16P2 = MgGlc16P2 3984 * Glc16P2 * (Kmgfru16p2 + Khf * Kmghf / pow(10, pH1)) * Mg / (1 + Khf / pow(10, pH1) + Kh2f * Khf / pow(10, 2 * pH1) + k1 * Kkf + k1 * Khf * Kkhf / pow(10, pH1)) - kmgf16p2d * MgGlc16P2 | |||
| vmgphos | vmgphos | Mg + Phos = MgPhos -kmgphosd * MgPhos + 40800 * (1 + 6.30957344480193 * pow(10, -8) * Khphos + 0.15 * Kkphos) * Mg * Phos / (1 + Khphos / pow(10, pH1) + k1 * Kkphos) | |||
| vox | vox | {2.0}GSH = GSSG kox * GSH | |||
| voxnadh | voxnadh | NADH = NAD koxNADH * NADH | |||
| vp6gdh | vp6gdh | P6G + NADP = CO2 + Ru5P + NADPH VP6GDH * (kp6gdh1 * kp6gdh3 * kp6gdh5 * kp6gdh7 * kp6gdh9 * kp6gdh11 * NADP * P6G - CO2 * kp6gdh2 * kp6gdh4 * kp6gdh6 * kp6gdh8 * kp6gdh10 * kp6gdh12 * NADPH * Ru5P) / (CO2 * kp6gdh2 * kp6gdh4 * kp6gdh6 * kp6gdh8 * kp6gdh11 + kp6gdh2 * (kp6gdh4 * kp6gdh6 + kp6gdh4 * kp6gdh7 + kp6gdh5 * kp6gdh7) * kp6gdh9 * kp6gdh11 + CO2 * kp6gdh1 * kp6gdh4 * kp6gdh6 * kp6gdh8 * kp6gdh11 * NADP + kp6gdh1 * (kp6gdh4 * kp6gdh6 + kp6gdh4 * kp6gdh7 + kp6gdh5 * kp6gdh7) * kp6gdh9 * kp6gdh11 * NADP + CO2 * kp6gdh2 * kp6gdh4 * kp6gdh6 * kp6gdh8 * kp6gdh12 * NADPH + kp6gdh2 * (kp6gdh4 * kp6gdh6 + kp6gdh4 * kp6gdh7 + kp6gdh5 * kp6gdh7) * kp6gdh9 * kp6gdh12 * NADPH + kp6gdh3 * kp6gdh5 * kp6gdh7 * kp6gdh9 * kp6gdh11 * P6G + CO2 * kp6gdh1 * kp6gdh3 * (kp6gdh5 + kp6gdh6) * kp6gdh8 * kp6gdh11 * NADP * P6G + kp6gdh1 * kp6gdh3 * (kp6gdh5 * kp6gdh7 * kp6gdh9 + kp6gdh5 * kp6gdh7 * kp6gdh11 + kp6gdh5 * kp6gdh9 * kp6gdh11 + kp6gdh6 * kp6gdh9 * kp6gdh11 + kp6gdh7 * kp6gdh9 * kp6gdh11) * NADP * P6G + kp6gdh3 * kp6gdh5 * kp6gdh7 * kp6gdh9 * kp6gdh12 * NADPH * P6G + CO2 * kp6gdh2 * kp6gdh4 * kp6gdh6 * kp6gdh8 * kp6gdh10 * Ru5P + CO2 * kp6gdh1 * kp6gdh4 * kp6gdh6 * kp6gdh8 * kp6gdh10 * NADP * Ru5P + kp6gdh2 * (kp6gdh4 * kp6gdh6 + kp6gdh4 * kp6gdh7 + kp6gdh5 * kp6gdh7) * kp6gdh10 * kp6gdh12 * NADPH * Ru5P + CO2 * (kp6gdh2 * kp6gdh4 + kp6gdh2 * kp6gdh5 + kp6gdh2 * kp6gdh6 + kp6gdh4 * kp6gdh6) * kp6gdh8 * kp6gdh10 * kp6gdh12 * NADPH * Ru5P + kp6gdh1 * kp6gdh3 * kp6gdh5 * kp6gdh7 * kp6gdh10 * NADP * P6G * Ru5P + CO2 * kp6gdh1 * kp6gdh3 * (kp6gdh5 + kp6gdh6) * kp6gdh8 * kp6gdh10 * NADP * P6G * Ru5P + kp6gdh3 * kp6gdh5 * kp6gdh7 * kp6gdh10 * kp6gdh12 * NADPH * P6G * Ru5P + CO2 * kp6gdh3 * (kp6gdh5 + kp6gdh6) * kp6gdh8 * kp6gdh10 * kp6gdh12 * NADPH * P6G * Ru5P) | |||
| vpfk | vpfk | Fru6P + MgATP = Fru16P2 + MgADP VPFK * (-(Fru16P2 * kcatfpfk * MgADP / (Kmpfkfru16p2 * Kmpfkmgadp)) + Fru6P * kcatfpfk * MgATP / (Kmpfkfru6p * Kmpfkmgatp)) / ((1 + Fru16P2 / Kmpfkfru16p2 + Fru6P / Kmpfkfru6p + MgADP / Kmpfkmgadp + Fru16P2 * MgADP / (Kmpfkfru16p2 * Kmpfkmgadp) + MgATP / Kmpfkmgatp + Fru6P * MgATP / (Kmpfkfru6p * Kmpfkmgatp)) * (1 + pow(1 / (pow(10, pH1) * Kapfk), npfk) * pow(1 + ATP / KTpfkatp, 4) * pow(1 + B23PG / KTpfkb23pg, 4) * pow(1 + Mg / KTpfkmg, 4) / (pow(1 + Fru16P2 / Kmpfkfru16p2 + Fru6P / Kmpfkfru6p, 4) * pow(1 + AMP / KRpfkamp, 4) * pow(1 + Glc16P2 / KRpfkglc16p2, 4) * pow(1 + Phos / KRpfkphos, 4)))) | |||
| vpgk | vpgk | B13PG + MgADP = P3GA + MgATP VPGK * (B13PG * kcatfpgk * MgADP / (Kipgkmgadp * Kmpgkb13pg) - kcatrpgk * MgATP * P3GA / (Kipgkmgatp * Kmpgkp3ga)) / (1 + B13PG / Kipgkb13pg + MgADP / Kipgkmgadp + B13PG * MgADP / (Kipgkmgadp * Kmpgkb13pg) + MgATP / Kipgkmgatp + P3GA / Kipgkp3ga + MgATP * P3GA / (Kipgkmgatp * Kmpgkp3ga)) | |||
| vpglhydrolysis | vpglhydrolysis | P6GL = P6G kspontaneouspglhydrolysis * P6GL + VLactonase * klactonase3 * P6GL / ((klactonase2 + klactonase3) / klactonase1 + P6GL) | |||
| vpgm | vpgm | P3GA = P2GA VPGM * (-(kcatrpgm * P2GA / Kmpgmp2ga) + kcatfpgm * P3GA / Kmpgmp3ga) / (1 + P2GA / Kmpgmp2ga + P3GA / Kmpgmp3ga) | |||
| vphostransport | vphostransport | Phos = Phose 2.85714 * (-kphostransporti * Phose * Ve + kphostransporti * (pow(10, -6.75 + pH1) / pow(rtv, 2) + 1 / rtv) * Ve * Phos / (1 + pow(10, -6.75 + pH1))) | |||
| vpk | vpk | PEP + MgADP = Pyr + MgATP VPK * (kcatfpk * MgADP * PEP / (KRpkmgadp * KRpkpep) - kcatrpk * MgATP * Pyr / (KRpkmgatp * KRpkpyr)) / ((1 + MgADP / KRpkmgadp + MgATP / KRpkmgatp + PEP / KRpkpep + MgADP * PEP / (KRpkmgadp * KRpkpep) + Pyr / KRpkpyr + MgATP * Pyr / (KRpkmgatp * KRpkpyr)) * (1 + 1.58489319246111 * pow(10, -7) * pow(10, pH1) * pow(1 + ATP / KTpkatp, 4) / (pow(1 + Fru16P2 / KRf16p2 + Glc16P2 / KRg16p2, 4) * pow(1 + PEP / KRpkpep + Pyr / KRpkpyr, 4)))) | |||
| vpyrtransport | vpyrtransport | Pyr = Pyre 2.85714 * (-kpyrtransporti * Pyre * Ve + kpyrtransporti * Ve * Pyr / rtv) | |||
| vr5pi | vr5pi | Ru5P = Rib5P VR5PI * (-(kr5pi2 * kr5pi4 * Rib5P / (kr5pi2 + kr5pi3)) + kr5pi1 * kr5pi3 * Ru5P / (kr5pi2 + kr5pi3)) / (1 + kr5pi1 * Ru5P / (kr5pi2 + kr5pi3) + kr5pi4 * Xu5P / (kr5pi2 + kr5pi3)) | |||
| vru5pe | vru5pe | Ru5P = Xu5P VRu5PE * (kru5pe1 * kru5pe3 * Ru5P / (kru5pe2 + kru5pe3) - kru5pe2 * kru5pe4 * Xu5P / (kru5pe2 + kru5pe3)) / (1 + kru5pe1 * Ru5P / (kru5pe2 + kru5pe3) + kru5pe4 * Xu5P / (kru5pe2 + kru5pe3)) | |||
| vta | vta | Sed7P + GraP = Ery4P + Fru6P VTA * (-Ery4P * Fru6P * kta2 * kta4 * kta6 * kta8 + GraP * kta1 * kta3 * kta5 * kta7 * Sed7P) / (GraP * (kta2 + kta3) * kta5 * kta7 + Ery4P * kta2 * kta4 * (kta6 + kta7) + Fru6P * GraP * (kta2 + kta3) * kta5 * kta8 + Fru6P * (kta2 + kta3) * kta6 * kta8 + Ery4P * Fru6P * kta4 * (kta2 + kta6) * kta8 + GraP * kta1 * kta5 * (kta3 + kta7) * Sed7P + kta1 * kta3 * (kta6 + kta7) * Sed7P + Ery4P * kta1 * kta4 * (kta6 + kta7) * Sed7P) | |||
| vtk1 | vtk1 | TK + Xu5P = TKXu5P ktk1 * TK * Xu5P - ktk2 * TKXu5P | |||
| vtk2 | vtk2 | TKXu5P = TKG + GraP ktk3 * TKXu5P - ktk4 * TKG * GraP | |||
| vtk3 | vtk3 | TKG + Rib5P = TKGRib5P ktk5 * TKG * Rib5P - ktk6 * TKGRib5P | |||
| vtk4 | vtk4 | TKGRib5P = TK + Sed7P ktk7 * TKGRib5P - ktk8 * TK * Sed7P | |||
| vtk5 | vtk5 | TKG + Ery4P = TKGEry4P ktk9 * TKG * Ery4P - ktk10 * TKGEry4P | |||
| vtk6 | vtk6 | TKGEry4P = TK + Fru6P ktk11 * TKGEry4P - ktk12 * TK * Fru6P | |||
| vtpi | vtpi | GraP = GrnP VTPI * (GraP * kcatftpi / Kmtpigrap - GrnP * kcatrtpi / Kmtpigrnp) / (1 + GraP / Kmtpigrap + GrnP / Kmtpigrnp) |
| Id | Value | |
|---|---|---|
| Hct | 0.5 | |
| KRf16p2 | 0.000005 | |
| KRg16p2 | 0.0001 | |
| KRpfkamp | 0.0003 | |
| KRpfkglc16p2 | 0.01 | |
| KRpfkphos | 0.03 | |
| KRpkmgadp | 0.000474 | |
| KRpkmgatp | 0.003 | |
| KRpkpep | 0.000225 | |
| KRpkpyr | 0.002 | |
| KTpfkatp | 0.0001 | |
| KTpfkb23pg | 0.005 | |
| KTpfkmg | 0.004 | |
| KTpkatp | 0.00339 | |
| Kahb | 0.000000251188643150958 | |
| Kapfk | 0.0000000891250938133746 | |
| Kdihkbpg | 0.004 | |
| Kdihkglc16p2 | 0.00003 | |
| Kdihkglc6p | 0.00001 | |
| Kdihkgsh | 0.003 | |
| Kh2bpg | 4270000.0 | |
| Kh2f | 1120000.0 | |
| Khadp | 5420000.0 | |
| Khamp | 3090000.0 | |
| Khatp | 9070000.0 | |
| Khbpg | 162000000.0 | |
| Khf | 7560000.0 | |
| Khphos | 5680000.0 | |
| Kialdb23pg | 0.0015 | |
| Kialdfru16p2 | 0.0000198 | |
| Kialdgrnp | 0.000011 | |
| Kidgapdhb13pg | 0.000001 | |
| Kidgapdhgrap | 0.000031 | |
| Kidldhpyr | 0.000101 | |
| Kienomg | 0.000046 | |
| Kienop2ga | 0.00014 | |
| Kienopep | 0.0001105 | |
| Kigapdhnad | 0.000045 | |
| Kigapdhphos | 0.00316 | |
| Kihkglc | 0.000047 | |
| Kihkglc6p | 0.000047 | |
| Kihkmgadp | 0.001 | |
| Kihkmgatp | 0.001 | |
| Kildhnad | 0.000503 | |
| Kildhnadh | 0.00000245 | |
| Kipgkb13pg | 0.0000016 | |
| Kipgkmgadp | 0.00008 | |
| Kipgkmgatp | 0.000186 | |
| Kipgkp3ga | 0.000205 | |
| Kkadp | 4.8 | |
| Kkamp | 1.8 | |
| Kkatp | 14.0 | |
| Kkbpg | 85.1 | |
| Kkf | 10.7 | |
| Kkhbpg | 8.9 | |
| Kkhf | 3.3 | |
| Kkphos | 3.0 | |
| Kmaldfru16p2 | 0.0000071 | |
| Kmaldgrap | 0.000189 | |
| Kmaldgrnp | 0.000035 | |
| Kmenomg | 0.000046 | |
| Kmenop2ga | 0.00014 | |
| Kmenopep | 0.0001105 | |
| Kmgadp | 3290.0 | |
| Kmgapdhb13pg | 0.000000671 | |
| Kmgapdhgrap | 0.000095 | |
| Kmgapdhnad | 0.000045 | |
| Kmgapdhphos | 0.00316 | |
| Kmgatp | 43200.0 | |
| Kmgbpg | 7410.0 | |
| Kmgfru16p2 | 363.0 | |
| Kmghadp | 107.0 | |
| Kmghatp | 748.0 | |
| Kmghbpg | 513.0 | |
| Kmghf | 89.0 | |
| Kmgpifru6p | 0.000071 | |
| Kmgpiglc6p | 0.000181 | |
| Kmhkmgadp | 0.001 | |
| Kmhkmgatp | 0.001 | |
| Kmldhnad | 0.000107 | |
| Kmldhnadh | 0.00000844 | |
| Kmldhplac | 0.000414 | |
| Kmldhppyr | 0.000414 | |
| Kmpfkfru16p2 | 0.0005 | |
| Kmpfkfru6p | 0.000075 | |
| Kmpfkmgadp | 0.00054 | |
| Kmpfkmgatp | 0.000068 | |
| Kmpgkb13pg | 0.000002 | |
| Kmpgkmgadp | 0.0001 | |
| Kmpgkmgatp | 0.001 | |
| Kmpgkp3ga | 0.0011 | |
| Kmpgmp2ga | 0.0000256 | |
| Kmpgmp3ga | 0.000168 | |
| Kmtpigrap | 0.000446 | |
| Kmtpigrnp | 0.0001624 | |
| VALD | 0.00000037 | |
| VENO | 0.00000022 | |
| VG6PDH | 0.000000093 | |
| VGDH | 0.00000766 | |
| VGPI | 0.000000218 | |
| VGSSGR | 0.000000125 | |
| VHK | 0.000000025 | |
| VLDH | 0.00000343 | |
| VLactonase | 0.000014 | |
| VP6GDH | 0.0000021 | |
| VPFK | 0.00000011 | |
| VPGK | 0.00000274 | |
| VPGM | 0.00000041 | |
| VPK | 0.000000087 | |
| VR5PI | 0.0000142 | |
| VRu5PE | 0.00000422 | |
| VTA | 0.00000069 | |
| VTPI | 0.00000114 | |
| Ve | 0.5 | |
| Vi | 0.35 | |
| alpha | 0.7 | |
| k1 | 0.15 | |
| katpase | 0.000585 | |
| kbpgsp10 | 1979.0 | |
| kbpgsp11 | 0.01 | |
| kbpgsp12 | 1000.0 | |
| kbpgsp14 | 1000000000.0 | |
| kbpgsp15 | 610000.0 | |
| kbpgsp16 | 0.19 | |
| kbpgsp2 | 400.0 | |
| kbpgsp5 | 100000000.0 | |
| kbpgsp7 | 1000.0 | |
| kbpgsp8 | 10000.0 | |
| kbpgsp9 | 0.55 | |
| kcatfald | 68.0 | |
| kcatfeno | 190.0 | |
| kcatfgpi | 1470.0 | |
| kcatfldh | 458.0 | |
| kcatfpfk | 822.0 | |
| kcatfpgk | 2290.0 | |
| kcatfpgm | 795.0 | |
| kcatfpk | 1386.0 | |
| kcatftpi | 14560.0 | |
| kcatrald | 234.0 | |
| kcatreno | 50.0 | |
| kcatrgpi | 1760.0 | |
| kcatrldh | 115.0 | |
| kcatrpfk | 36.0 | |
| kcatrpgk | 917.0 | |
| kcatrpgm | 714.0 | |
| kcatrpk | 3.26 | |
| kcatrtpi | 1280.0 | |
| kfldhp | 0.00346 | |
| kg6pdh1 | 110000000.0 | |
| kg6pdh10 | 1400000000.0 | |
| kg6pdh2 | 870.0 | |
| kg6pdh3 | 26000000.0 | |
| kg6pdh4 | 300.0 | |
| kg6pdh5 | 750.0 | |
| kg6pdh6 | 2000.0 | |
| kg6pdh7 | 220000.0 | |
| kg6pdh8 | 1100000000.0 | |
| kg6pdh9 | 10000.0 | |
| kgssgr1 | 85000000.0 | |
| kgssgr10 | 50000000.0 | |
| kgssgr11 | 7000.0 | |
| kgssgr12 | 100000000.0 | |
| kgssgr2 | 510.0 | |
| kgssgr3 | 1000000000.0 | |
| kgssgr4 | 72000.0 | |
| kgssgr5 | 810.0 | |
| kgssgr6 | 1000.0 | |
| kgssgr7 | 1000000.0 | |
| kgssgr8 | 50000000.0 | |
| kgssgr9 | 1000000.0 | |
| khbadpd | 1200.0 | |
| khbatpd | 1200.0 | |
| khbb13pgd | 1200.0 | |
| khbbpgd | 1200.0 | |
| khbmgatpd | 1200.0 | |
| klactonase1 | 13000000.0 | |
| klactonase2 | 1000.0 | |
| klactonase3 | 29.0 | |
| klactransporti | 0.0036 | |
| kmgadpd | 1200.0 | |
| kmgatpd | 1200.0 | |
| kmgb13pgd | 1200.0 | |
| kmgbpgd | 1200.0 | |
| kmgf16p2d | 1200.0 | |
| kmgphosd | 1200.0 | |
| kox | 0.000034 | |
| koxNADH | 0.0163 | |
| kp6gdh1 | 2400000.0 | |
| kp6gdh10 | 225000.0 | |
| kp6gdh11 | 300.0 | |
| kp6gdh12 | 4950000.0 | |
| kp6gdh2 | 410.0 | |
| kp6gdh3 | 2000000000.0 | |
| kp6gdh4 | 26000.0 | |
| kp6gdh5 | 48.0 | |
| kp6gdh6 | 30.0 | |
| kp6gdh7 | 630.0 | |
| kp6gdh8 | 36000.0 | |
| kp6gdh9 | 800.0 | |
| kphostransporti | 0.00056 | |
| kpyrtransporti | 0.018 | |
| kr5pi1 | 60900.0 | |
| kr5pi2 | 33.3 | |
| kr5pi3 | 14.2 | |
| kr5pi4 | 21600.0 | |
| krldhp | 0.000000543 | |
| kru5pe1 | 3910000.0 | |
| kru5pe2 | 438.0 | |
| kru5pe3 | 305.0 | |
| kru5pe4 | 1490000.0 | |
| kspontaneouspglhydrolysis | 0.00071 | |
| kta1 | 580000.0 | |
| kta2 | 45.3 | |
| kta3 | 16.3 | |
| kta4 | 1010000.0 | |
| kta5 | 490000.0 | |
| kta6 | 60.0 | |
| kta7 | 17.0 | |
| kta8 | 79000.0 | |
| ktk1 | 216000.0 | |
| ktk10 | 175.0 | |
| ktk11 | 40.0 | |
| ktk12 | 21300.0 | |
| ktk2 | 38.0 | |
| ktk3 | 34.0 | |
| ktk4 | 156000.0 | |
| ktk5 | 329000.0 | |
| ktk6 | 175.0 | |
| ktk7 | 40.0 | |
| ktk8 | 44800.0 | |
| ktk9 | 2240000.0 | |
| npfk | 5.0 | |
| pH1 | 7.2 | |
| rtv | 0.69 |
| Id | Value | Reaction |
|---|
| Definition |
|---|
| Definition |
|---|
| Definition |
|---|
| Definition |
|---|
| Trigger | Assignments |
|---|