S12 S4 cell kb_p21c2 kb_p21c2 S4 S12 cell cell ks_c4 tf ks_c4 tf cell S14 S16 cell ks_c2e2f ks_c2myc tf ks_c2myc tf ks_c2e2f S14 S16 cell S22 cell k_delay k_delay S22 cell S24 cell kdeg_c4 kdeg_c4 S24 cell S3 cell gsk3b kdeg_c2 kdeg_c2gsk3b kdeg_c2 kdeg_c2gsk3b gsk3b S3 cell S4 cell gsk3b kdeg_c2 kdeg_c2gsk3b kdeg_c2 kdeg_c2gsk3b gsk3b S4 cell S14 cell ks_p21e2f ks_p21p53 tfp21 ks_p21p53 ks_p21e2f S14 tfp21 cell S3 cell kd_p21c2 kd_p21c2 S3 cell S1 cell kdeg_rbfree kdeg_rbfree S1 cell S2 cell kdeg_rbbound kdeg_rbbound S2 cell S1 S11 cell kdeg_rbp21 kdeg_rbp21 S11 S1 cell S11 S2 cell kdeg_rbp21 kdeg_rbp21 S11 S2 cell S14 cell ks_e2fe2f ks_e2fmyc tf ks_e2fe2f S14 ks_e2fmyc tf cell S2 cell kdeg_e2fbound kdeg_e2fbound S2 cell S2 cell kd_rbe2f kd_rbe2f S2 cell Km_prb S2 S24 cell kcatp_rbc4 nrb kcatp_rbc4 S24 S2 nrb Km_prb nrb S2 nrb cell S14 S18 S5 cell k_dna k_dna S18 S14 S5 cell S10 cell gsk3b kdeg_c4 kdeg_c4gsk3b kdeg_c4 kdeg_c4gsk3b gsk3b S10 cell S13 cell kp_c2cak kp_c2cak S13 cell S10 S12 cell kb_p21c4 kb_p21c4 S10 S12 cell S11 S13 cell kb_p21c2 kb_p21c2 S11 S13 cell S12 Vratio cell kimport kimport Vratio S12 cell S12 Vratio cell kimport kimport 1 1 Vratio S12 cell S12 cell erk gsk3b kdeg_p21erk kdeg_p21gsk3b kdeg_p21gsk3b gsk3b kdeg_p21erk erk S12 cell S15 cell kdeg_rbfree kdeg_rbfree S15 cell S11 S15 cell kdeg_rbp21 kdeg_rbp21 S11 S15 cell S11 S16 cell kdeg_rbp21 kdeg_rbp21 S11 S16 cell S14 cell kdeg_e2ffree kdeg_e2ffree S14 cell S16 cell kdeg_e2fbound kdeg_e2fbound S16 cell S1 S14 cell kb_rbe2f kb_rbe2f S1 S14 cell S16 cell kd_rbpe2f kd_rbpe2f S16 cell Km_prb S15 S18 cell kcatp_rbc2 nrb kcatp_rbc2 S18 S15 nrb Km_prb nrb S15 nrb cell Km_prb S16 S18 cell kcatp_rbc2 nrb kcatp_rbc2 S18 S16 nrb Km_prb nrb S16 nrb cell Km_dprb S15 S18 cell kcatdp_rbc4 kinh_pp1 nrb kcatdp_rbc4 S15 nrb Km_dprb nrb S15 nrb 1 1 kinh_pp1 S18 cell S17 cell k_delay k_delay S17 cell Km_dprb S16 S18 cell kcatdp_rbc4 kinh_pp1 nrb kcatdp_rbc4 S16 nrb Km_dprb nrb S16 nrb 1 1 kinh_pp1 S18 cell S20 cell kd_p21c2 kd_p21c2 S20 cell S11 S18 cell kb_p21c2 kb_p21c2 S11 S18 cell S19 cell kd_p21c4 kd_p21c4 S19 cell S18 cell kdp_c2cak kdp_c2cak S18 cell S18 cell gsk3b kdeg_c2c2gsk3b kdeg_c2c2gsk3b gsk3b S18 cell S20 cell gsk3b kdeg_c2 kdeg_c2gsk3b kdeg_c2 kdeg_c2gsk3b gsk3b S20 cell S18 cell gsk3b kdeg_c2 kdeg_c2gsk3b kdeg_c2 kdeg_c2gsk3b gsk3b S18 cell S19 cell gsk3b kdeg_c4 kdeg_c4gsk3b kdeg_c4 kdeg_c4gsk3b gsk3b S19 cell S23 cell kd_p21c2 kd_p21c2 S23 cell S24 cell kd_p21c4 kd_p21c4 S24 cell S23 cell gsk3b kdeg_c2 kdeg_c2gsk3b kdeg_c2 kdeg_c2gsk3b gsk3b S23 cell Km_dprb S18 S21 cell kcatdp_rbc2 kinh_pp1 nrb kcatdp_rbc2 S21 nrb Km_dprb nrb S21 nrb 1 1 kinh_pp1 S18 cell S11 S21 cell kdeg_rbp21 kdeg_rbp21 S11 S21 cell S21 cell kdeg_rbfree kdeg_rbfree S21 cell S20 Vratio cell kimport kimport 1 1 Vratio S20 cell S28 cell k_delay k_delay S28 cell S27 cell k_delay k_delay S27 cell S11 S26 cell kb_p21c4 kb_p21c4 S11 S26 cell S26 cell gsk3b kdeg_c4 kdeg_c4gsk3b kdeg_c4 kdeg_c4gsk3b gsk3b S26 cell S25 cell k_delay k_delay S25 cell S14 S18 S24 cell erk kdeg_p21c2skp2 kdeg_p21erkskp2 kdeg_p21skp2 kdeg_p21erkskp2 erk kdeg_p21c2skp2 S18 kdeg_p21skp2 S14 S24 cell S14 S18 S23 cell erk kdeg_p21c2skp2 kdeg_p21erkskp2 kdeg_p21skp2 kdeg_p21erkskp2 erk kdeg_p21c2skp2 S18 kdeg_p21skp2 S14 S23 cell S19 Vratio cell kimport kimport 1 1 Vratio S19 cell S20 Vratio cell kimport kimport Vratio S20 cell S19 Vratio cell kimport kimport Vratio S19 cell S14 S15 cell kb_rbpe2f kb_rbpe2f S14 S15 cell S16 cell kdeg_rbbound kdeg_rbbound S16 cell S11 cell erk gsk3b kdeg_p21erk kdeg_p21gsk3b kdeg_p21gsk3b gsk3b kdeg_p21erk erk S11 cell S13 cell gsk3b kdeg_c2 kdeg_c2gsk3b kdeg_c2 kdeg_c2gsk3b gsk3b S13 cell Km_prb S1 S24 cell kcatp_rbc4 nrb kcatp_rbc4 S24 S1 nrb Km_prb nrb S1 nrb cell S14 cell ks_rb ks_rbe2f ks_rb ks_rbe2f S14 cell S14 S18 S3 cell erk kdeg_p21c2skp2 kdeg_p21erkskp2 kdeg_p21skp2 kdeg_p21erkskp2 erk kdeg_p21c2skp2 S18 kdeg_p21skp2 S14 S3 cell 
p21:CDK2 complex
 
DNA content
 
Rb S788-phosphorylated (serine 788 site)
 
Rb S800/S804-phosphorylated (serine 800 and 804 sites)
 
CDK2 T160-phosphorylated (Thr160 site)
 
Cyclin D1:CDK4 complex
 
Cyclin E:CDK2 complex
 
E2F-1 - E2F transcription factor
 
p21 - Cyclin-dependent kinase inhibitor 1
 
Retinoblastoma Protein
 
Retinoblastoma Protein - S788 and S800 phosphorylation
 
Cyclin D1:CDK4 complex
 
p21 - Cyclin-dependent kinase inhibitor 1
 
p21 - Cyclin-dependent kinase inhibitor 1
 
Cyclin E:CDK2 complex - T160 phosphorylation
 
E2F-1 - E2F transcription factor
 
Retinoblastoma Protein - S788 and S800 phosphorylation
 
E2F-1: Retinoblastoma Protein complex - S788 and S800 phosphorylation
 
Genes contributing to the formation of prereplication complexes.
 
Cyclin E:CDK2 complex - T160 phosphorylation
 
Cyclin D1:CDK4:p21 complex
 
E2F-1: Retinoblastoma Protein complex - S788 and S800 phosphorylation
 
Cyclin E:CDK2:p21 complex - T160 phosphorylation
 
Retinoblastoma Protein - S788 and S800 phosphorylation
 
Genes contributing to the formation of prereplication complexes.
 
Cyclin E:CDK2:p21 complex - T160 phosphorylation
 
Cyclin D1:CDK4:p21 complex
 
Genes contributing to the formation of prereplication complexes.
 
Cyclin D1:CDK4 complex
 
Genes contributing to the formation of prereplication complexes.
 
Genes contributing to the formation of prereplication complexes.
 
Cyclin E:CDK2:p21 complex - T160 phosphorylation
 
Cyclin E:CDK2 complex - T160 phosphorylation
 
Genes contributing to the formation of prereplication complexes.
 
Hepatocyte Growth Factor
 
Protein kinase B
 
Cyclin D1:CDK4 complex
 
Extracellular-signal-regulated Kinases
 
p53 tumor suppressor
 kdeg_e2fbound kdege2fplus kcatprbc4 1 inhc4d1 kb_rbpe2f Kd_rbp_e2f kb_rbe2f Kd_rb_e2f 0 time 1 0 time 24 1 0 time 1 0 time 0 0 0 time 1 0 time 0 0 0 time 1 0 time 0 0 0 time 1 0 time 0 0 scale_TotE2F scale_TotRb Vnuc S2 S14 S16 Vnuc Vcyto scale_TotCDK2T160 Vnuc S18 S23 Vnuc Vcyto scale_TotcycDCDK4 Vnuc S24 Vcyto S19 Vnuc Vcyto scale_PhosRbS788 Vnuc S15 S16 S21 Vnuc Vcyto scale_PhosRbS800 Vnuc S21 Vnuc Vcyto 2 S5 S17 S22 S25 S27 S28 Vnuc Vcyto 1 akt 1 atf erk 1 gsk3b atf kdp_c2cak kc2cak Kd_p21c4 kb_p21c4 Kd_p21c2 kb_p21c2 kdeg_rbbound kdegrbplus ki 1 kinh_p21akt akt 1 inhp53 tf 1 inhakt 1 aakt pakt nakt 1 hgf nakt hgf nakt pakt nakt aakt 1 inherk 1 aerk perk nerk 1 hgf nerk hgf nerk perk nerk aerk scale_TotRb Vnuc S1 S2 S15 S16 S21 Vnuc Vcyto scale_Totp21 Vnuc S3 S11 S23 S24 Vcyto S12 S19 S20 Vnuc Vcyto scale_TotcycECDK2 Vnuc S3 S13 S18 S23 Vcyto S4 S20 Vnuc Vcyto scale_Totp21CDK2 Vnuc S3 S23 Vcyto S20 Vnuc Vcyto cell Function_for_reaction_1_0 cell ks_c4 tf Nucleus Function_for_reaction_10_0 S2 cell kdeg_rbbound Nucleus Function_for_reaction_11_0 S1 S11 cell kdeg_rbp21 Nucleus Function_for_reaction_12_0 S11 S2 cell kdeg_rbp21 Nucleus Function_for_reaction_13_0 S14 cell ks_e2fe2f ks_e2fmyc tf Nucleus Function_for_reaction_14_0 S2 cell kdeg_e2fbound Nucleus Function_for_reaction_15_0 S2 cell kd_rbe2f Nucleus Function_for_reaction_16_0 Km_prb S1 S24 cell kcatp_rbc4 nrb Nucleus Function_for_reaction_17_0 Km_prb S2 S24 cell kcatp_rbc4 nrb Nucleus Function_for_reaction_18_0 S14 S18 S5 cell k_dna cell Function_for_reaction_19_0 S10 cell gsk3b kdeg_c4 kdeg_c4gsk3b cell Function_for_reaction_2_0 S14 S16 cell ks_c2e2f ks_c2myc tf Nucleus Function_for_reaction_20_0 S13 cell gsk3b kdeg_c2 kdeg_c2gsk3b Nucleus Function_for_reaction_21_0 S13 cell kp_c2cak cell Function_for_reaction_22_0 S10 S12 cell kb_p21c4 cell Function_for_reaction_23_0 S12 S4 cell kb_p21c2 Nucleus Function_for_reaction_24_0 S11 S13 cell kb_p21c2 Function_for_reaction_25_0 S12 Vratio cell kimport cell Function_for_reaction_26_0 S12 Vratio cell kimport Nucleus Function_for_reaction_27_0 S11 cell erk gsk3b kdeg_p21erk kdeg_p21gsk3b cell Function_for_reaction_28_0 S12 cell erk gsk3b kdeg_p21erk kdeg_p21gsk3b Nucleus Function_for_reaction_29_0 S15 cell kdeg_rbfree Nucleus Function_for_reaction_3_0 S3 cell gsk3b kdeg_c2 kdeg_c2gsk3b Nucleus Function_for_reaction_30_0 S16 cell kdeg_rbbound Nucleus Function_for_reaction_31_0 S11 S15 cell kdeg_rbp21 Nucleus Function_for_reaction_32_0 S11 S16 cell kdeg_rbp21 Nucleus Function_for_reaction_33_0 S14 cell kdeg_e2ffree Nucleus Function_for_reaction_34_0 S16 cell kdeg_e2fbound Nucleus Function_for_reaction_35_0 S1 S14 cell kb_rbe2f Nucleus Function_for_reaction_36_0 S14 S15 cell kb_rbpe2f Nucleus Function_for_reaction_37_0 S16 cell kd_rbpe2f Nucleus Function_for_reaction_38_0 Km_prb S15 S18 cell kcatp_rbc2 nrb Nucleus Function_for_reaction_39_0 Km_prb S16 S18 cell kcatp_rbc2 nrb cell Function_for_reaction_4_0 S4 cell gsk3b kdeg_c2 kdeg_c2gsk3b Nucleus Function_for_reaction_40_0 Km_dprb S15 S18 cell kcatdp_rbc4 kinh_pp1 nrb Nucleus Function_for_reaction_41_0 Km_dprb S16 S18 cell kcatdp_rbc4 kinh_pp1 nrb Nucleus Function_for_reaction_42_0 S17 cell k_delay cell Function_for_reaction_43_0 S19 cell gsk3b kdeg_c4 kdeg_c4gsk3b Nucleus Function_for_reaction_44_0 S18 cell gsk3b kdeg_c2 kdeg_c2gsk3b cell Function_for_reaction_45_0 S20 cell gsk3b kdeg_c2 kdeg_c2gsk3b Nucleus Function_for_reaction_46_0 S18 cell gsk3b kdeg_c2c2gsk3b Nucleus Function_for_reaction_47_0 S18 cell kdp_c2cak cell Function_for_reaction_48_0 S19 cell kd_p21c4 Nucleus Function_for_reaction_49_0 S11 S18 cell kb_p21c2 cell Function_for_reaction_5_0 S14 cell ks_p21e2f ks_p21p53 tfp21 cell Function_for_reaction_50_0 S20 cell kd_p21c2 Function_for_reaction_51_0 S19 Vratio cell kimport Function_for_reaction_52_0 S20 Vratio cell kimport cell Function_for_reaction_53_0 S19 Vratio cell kimport cell Function_for_reaction_54_0 S20 Vratio cell kimport Nucleus Function_for_reaction_55_0 S21 cell kdeg_rbfree Nucleus Function_for_reaction_56_0 S11 S21 cell kdeg_rbp21 Nucleus Function_for_reaction_57_0 Km_dprb S18 S21 cell kcatdp_rbc2 kinh_pp1 nrb Nucleus Function_for_reaction_58_0 S22 cell k_delay Nucleus Function_for_reaction_59_0 S24 cell kdeg_c4 Nucleus Function_for_reaction_6_0 S3 cell kd_p21c2 Nucleus Function_for_reaction_60_0 S23 cell gsk3b kdeg_c2 kdeg_c2gsk3b Nucleus Function_for_reaction_61_0 S24 cell kd_p21c4 Nucleus Function_for_reaction_62_0 S23 cell kd_p21c2 Nucleus Function_for_reaction_63_0 S14 S18 S23 cell erk kdeg_p21c2skp2 kdeg_p21erkskp2 kdeg_p21skp2 Nucleus Function_for_reaction_64_0 S14 S18 S24 cell erk kdeg_p21c2skp2 kdeg_p21erkskp2 kdeg_p21skp2 Nucleus Function_for_reaction_65_0 S25 cell k_delay Nucleus Function_for_reaction_66_0 S26 cell gsk3b kdeg_c4 kdeg_c4gsk3b Nucleus Function_for_reaction_67_0 S11 S26 cell kb_p21c4 Nucleus Function_for_reaction_68_0 S27 cell k_delay Nucleus Function_for_reaction_69_0 S28 cell k_delay Nucleus Function_for_reaction_7_0 S14 S18 S3 cell erk kdeg_p21c2skp2 kdeg_p21erkskp2 kdeg_p21skp2 Nucleus Function_for_reaction_8_0 S14 cell ks_rb ks_rbe2f Nucleus Function_for_reaction_9_0 S1 cell kdeg_rbfree