v_1
v_1
sn = {0.0684492}sc
v_2
{0.0684492}sc = sn
v_3
sc = psc
v_4
v_4
psc = {0.5}ps2c
v_5
ps2c = {2.0}psc
v_6
{0.0684492}ps2c = ps2n
v_7
v_7
psn = {0.5}ps2n
v_8
ps2n = {2.0}psn
v_9
psn = sn
Assignment rules
sk = piecewise(0,time < lag, 0, time > lag + period, ampl*sin(pi/period*(time-lag)))
Function definitions
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
STAT module can function as a biphasic amplitude filter.
Syst Biol (Stevenage) 2005;
2
(1):
43
- PubMed: 17091582
- ISSN: 1741-2471
- URL: http://ncbi.nlm.nih.gov/pubmed/17091582
Abstract
Signal transducer and actuator of transcription (STATs) are a family of transcription factors activated by various cytokines, growth factors and hormones. They are important mediators of immune responses and growth and differentiation of various cell types. The STAT signalling system represents a defined functional module with a pattern of signalling that is conserved from flies to mammals. In order to probe and gain insights into the signalling properties of the STAT module by computational means, we developed a simple non-linear ordinary differential equations model within the 'Virtual Cell' framework. Our results demonstrate that the STAT module can operate as a 'biphasic amplitude filter' with an ability to amplify input signals within a specific intermediate range. We show that dimerisation of phosphorylated STAT is crucial for signal amplification and the amplitude filtering function. We also demonstrate that maximal amplification at intermediate levels of STAT activation is a moderately robust property of STAT module. We propose that these observations can be extrapolated to the analogous SMAD signalling module.
No additional notes are available for this model.