r1
r1
II > M
r2
r2
M > IIa
r3
r3
II > P2
r4
r4
P2 > IIa
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
A revisit to the one form kinetic model of prothrombinase.
Biophys. Chem. 2010;
149
:
28
- PubMed: 20435402
- PubMed Central: PMC2877601
- DOI: 10.1016/j.bpc.2010.03.011
- ISSN: 1873-4200
- URL: https://ncbi.nlm.nih.gov/pubmed/20435402
Abstract
Thrombin is generated enzymatically from prothrombin by two pathways with the intermediates of meizothrombin and prethrombin-2. Experimental concentration profiles from two independent groups for these two pathways have been re-analyzed. By rationally combining the independent data sets, a simple mechanism can be established and rate constants determined. A structural model is consistent with the data-derived finding that mechanisms that feature channeling or ratcheting are not necessary to describe thrombin production.
The SBML for this model was obtained from the BioModels database (BioModels ID: BIOMD0000000363)
Biomodels notes: Reproduction of figure S9 of the supplementary material. Model integrated using PySCeS and plotted with Matplotlib.
JWS Online curation: This model was curated by reproducing the figures as described in the BioModels Notes. No additional changes were made.