lee2

The SBML for this model was obtained from the BioModels database (BioModels ID: BIOMD0000000357) Biomodels notes: Reproduction of figure S6 of the supplementary material. Model integrated using PySCeS and plotted with Matplotlib. JWS Online curation: This model was curated by reproducing the figures as described in the BioModels Notes. No additional changes were made.

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A revisit to the one form kinetic model of prothrombinase.

  • Chang Jun Lee
  • Sangwook Wu
  • Changsun Eun
  • Lee G Pedersen
Biophys. Chem. 2010; 149 : 28
Abstract
Thrombin is generated enzymatically from prothrombin by two pathways with the intermediates of meizothrombin and prethrombin-2. Experimental concentration profiles from two independent groups for these two pathways have been re-analyzed. By rationally combining the independent data sets, a simple mechanism can be established and rate constants determined. A structural model is consistent with the data-derived finding that mechanisms that feature channeling or ratcheting are not necessary to describe thrombin production.

Unit definitions have no effect on the numerical analysis of the model. It remains the responsibility of the modeler to ensure the internal numerical consistency of the model. If units are provided, however, the consistency of the model units will be checked.

Name Definition
1e-06 mole
Id Name Spatial dimensions Size
compartment compartment 3.0 1.0
Id Name Initial quantity Compartment Fixed
E E 0.00015 compartment (compartment)
E_M E_M 0.0 compartment (compartment)
E_P2 E_P2 0.0 compartment (compartment)
E_P_1 E_P_1 0.0 compartment (compartment)
E_P_2 E_P_2 0.0 compartment (compartment)
M M 0.0 compartment (compartment)
P P 1.0 compartment (compartment)
P2 P2 0.0 compartment (compartment)
T T 0.0 compartment (compartment)

Initial assignments are expressions that are evaluated at time=0. It is not recommended to create initial assignments for all model entities. Restrict the use of initial assignments to cases where a value is expressed in terms of values or sizes of other model entities. Note that it is not permitted to have both an initial assignment and an assignment rule for a single model entity.

Definition
Id Name Objective coefficient Reaction Equation and Kinetic Law Flux bounds
r1 r1 E + P = E_P_1

compartment * (k1 * E * P - j1 * E_P_1)
r12 r12 E + P2 = E_P2

compartment * (k7a * E * P2 - j7a * E_P2)
r14 r14 E_P2 > E + T

compartment * k8a * E_P2
r2 r2 E_P_1 > E + M

compartment * k2 * E_P_1
r5 r5 E + M = E_M

compartment * (k3a * E * M - j3a * E_M)
r7 r7 E_M > E + T

compartment * k4a * E_M
r8 r8 E + P = E_P_2

compartment * (k5 * E * P - j5 * E_P_2)
r9 r9 E_P_2 > E + P2

compartment * k6 * E_P_2

Global parameters

Id Value
j1 33.4
j3a 0.185
j5 21.8
j7a 0.0000266
k1 91.8
k2 82.4
k3a 151.5
k4a 209.9
k5 5.16
k6 32.3
k7a 4.7
k8a 42.6

Local parameters

Id Value Reaction

Assignment rules

Definition

Rate rules

Definition

Algebraic rules

Definition
Trigger Assignments