Open conformation of Mad2

u = 1 : kinetochore unattached
u = 0 : kinetochore attached u = 0 : kinetochore unattached
u = 1 : kinetochore attached

Cytoplasm u k1f Mad1_CMad2 OMad2 k1r Mad1_CMad2_OMad2

u k2f Mad1_CMad2_OMad2 Cytoplasm Cdc20

k3f Cdc20_CMad2 Cytoplasm

Cytoplasm u k4f Cdc20_CMad2 Bub3_BubR1 k4r MCC

Cytoplasm u k5f Bub3_BubR1 Cdc20 k5r Bub3_BubR1_Cdc20

kf6 OMad2 Cdc20 Cytoplasm

u k7f MCC APC Cytoplasm

u_prime k7r MCC_APC Cytoplasm

Cytoplasm k8f APC Cdc20 k8r APC_Cdc20

time 2000

const_val_0

const_val_1