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A revisit to the one form kinetic model of prothrombinase.

Chang Jun Lee
Sangwook Wu
Changsun Eun
Lee G Pedersen

Biophys. Chem. 2010; 149 : 28

PubMed: 20435402
PubMed Central: PMC2877601
DOI: 10.1016/j.bpc.2010.03.011
ISSN: 1873-4200
URL: https://ncbi.nlm.nih.gov/pubmed/20435402

Abstract

Thrombin is generated enzymatically from prothrombin by two pathways with the intermediates of meizothrombin and prethrombin-2. Experimental concentration profiles from two independent groups for these two pathways have been re-analyzed. By rationally combining the independent data sets, a simple mechanism can be established and rate constants determined. A structural model is consistent with the data-derived finding that mechanisms that feature channeling or ratcheting are not necessary to describe thrombin production.

Models 1

Id	Name	JWS model
model0_lee2	lee2	lee2

Data Description 0

Id	Name	Source	Number of Data Sources

Simulation Tasks 1

Id	Name	Model	Simulation	Simulation	Simulation
task0_model0_lee2	—	lee2	0.0	900.0	1000

Outputs 0 1

2D Plots

Id	Name	Number of Curves
Figure_S6	Figure S6	4

CSV Reports

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