time T fup_ZF ZF_blood ZF_airways fup_ML ML_blood fup_ML ML_blood npi diam_EO 3 0 6 0 EO_a_b N_A_pmole w_EO V_B EO_a_aw N_A_pmole w_EO V_AW GS_pool_b GSH_b 2 0 1 0 Ca K_PLA2_Ca Ki_AA Ki_AA HPETE_b LOOH_b HETE_b LOH_b k_ox k_ox2 Ca K_Ca2 k_red k_red2 Ca K_Ca2 k_lo AA_b K_AA k3 HPETE_b 1 0 AA_b Ki_AA k_lta_syn k_3 1 0 AA_b Ki_HPETE_AA FLOa DFLOa_b FLO3_b REDOX_b FLO3_b 1 0 Ca K_Ca3 FLO2_b 1 0 Ca K_Ca2 FLO3t_b RELFLO5_b HPETE_b GSH_b GSH_b Km_gpx_HPETE5 Km_gpx_GSH Km_gpx_GSH 1 0 LTA4_b K_LTA GSH_b K_GSH LTA4_b GSH_b K_LTA K_LTA_GSH LTC4_b K_LTC 1 0 HETE_b Kd_hedh_HETE5 NADPH_b Kd_hedh_NADPH k_hedh_3 oxoETE_b Kd_hedh_oxoETE5 k_hedh_2 NADP_b Kd_hedh_NADP GS_pool_aw GSH_aw 2 0 NP_pool_aw NADP_aw HPETE_aw LOOH_aw HETE_aw LOH_aw k_lo AA_aw K_AA k3 HPETE_aw 1 0 AA_aw Ki_AA k_lta_syn k_3 1 0 AA_aw Ki_HPETE_AA FLOa DFLOa_aw FLO3_aw REDOX_aw FLO3_aw 1 0 Ca K_Ca3 FLO2_aw 1 0 Ca K_Ca2 FLO3t_aw RELFLO5_aw HPETE_aw GSH_aw GSH_aw Km_gpx_HPETE5 Km_gpx_GSH Km_gpx_GSH k_gpx_cat HPETE_aw GSH_aw GSH_aw Km_gpx_HPETE5 Km_gpx_GSH Km_gpx_GSH delta_LTCs_aw K_LTA_GSH K_GSH K_LTC 1 0 HETE_aw Kd_hedh_HETE5 NADPH_aw Kd_hedh_NADPH k_hedh_3 oxoETE_aw Kd_hedh_oxoETE5 k_hedh_2 NADP_aw Kd_hedh_NADP k_hedh_1 k_hedh_2 HETE_aw NADP_aw Kd_hedh_HETE5 Kd_hedh_NADP oxoETE_aw NADPH_aw k_hedh_3 k_hedh_4 Kd_hedh_oxoETE5 Kd_hedh_NADPH portion_migr fup_LT LTE4_b Kd_LTE_migr fup_LT LTE4_b 1 0 portion_migr IL_b Kd_IL_migr IL_b r_out_FEV R_FEV R_in_relax_FEV R_FEV r_out_FEV 5 -1 MAX_FEV r_in_FEV R_in_relax_FEV 2 0 time 6 1 time 1.44 3 EO_bm 6.02 0 1 1 8 0 EO_b 6.02 0 1 1 8 0 EO_i_b 6.02 0 1 1 8 0 EO_b EO_i_b EO_a_b EO_b EO_i_b EO_a_b 6.02 0 1 1 8 0 EO_aw 6.02 0 1 1 8 0 EO_i_aw 6.02 0 1 1 8 0 EO_a_aw 6.02 0 1 1 8 0 EO_aw EO_i_aw EO_a_aw EO_aw EO_i_aw EO_a_aw 6.02 0 1 1 8 0 1 2 EO_b_tot 5.33 -4 5.33 -4 N_EO_aw_tot 8.18735 5 1 2 N_EO_b_tot 4.266021 6 1 2 LTC4_b 1 6 N_EO_a_b V_B N_EO_a_aw V_AW V_B V_AW N_EO_b_tot V_B N_EO_aw_tot V_AW V_B V_AW 1 2 N_EO_aw_tot 8.18735 5 1 2 Hn_aw 1.4162 4 1 2 N_EO 3.58758 5 R1_portion_FEV LTD4_aw Kd_LTR1_FEV 1 0 LTD4_aw Kd_LTR1_FEV ML_airways_conc EC50_ML_FEV R2_portion_FEV LTD4_aw LTC4_aw_out Kd_LTR2_FEV 1 0 LTD4_aw LTC4_aw_out Kd_LTR2_FEV 1 0 R1_portion_FEV R2_portion_FEV Hn_aw Kd_Hn_FEV 1 0 Hn_aw Kd_Hn_FEV k_fev_eff R2_portion_FEV LTD4_aw LTC4_aw_out Kd_LTR2_FEV 1 0 LTD4_aw LTC4_aw_out Kd_LTR2_FEV 1 0 R1_portion_FEV R2_portion_FEV Hn_aw Kd_Hn_FEV 1 0 Hn_aw Kd_Hn_FEV Ca_FEV Cao_FEV k_fev_eff R1_portion_FEV LTD4_aw Kd_LTR1_FEV 1 0 LTD4_aw Kd_LTR1_FEV ML_airways_conc EC50_ML_FEV Ca_FEV Cao_FEV 1 2 LTD4_aw 2.0576 2 ML_blood 1 6 LTD4_b fup_LT LTC4_aw_out fup_LT M_LTC LTD4_aw fup_LT M_LTD LTE4_aw fup_LT M_LTE 1 3 EO_a_b 6.02 0 1 1 8 0 FEV1 3.528 0 3.528 0 1 2 TSN_0 R_FEV R_FEV R_FEV R_in_relax_FEV 2 0 1 0 3 0 Ca_FEV n_FEV K_Ca_FEV n_FEV Ca_FEV n_FEV TSN_0 R_FEV R_FEV R_FEV R_in_relax_FEV 2 0 1 0 3 0 Ca_FEV_ex n_FEV K_Ca_FEV n_FEV Ca_FEV_ex n_FEV R_FEV R_FEV R_FEV R_FEV R_in_relax_FEV 2 0 1 0 3 0 Ca_FEV n_FEV K_Ca_FEV n_FEV Ca_FEV n_FEV Cao_FEV k_fev_eff R1_portion_FEV LTD4_aw Kd_LTR1_FEV 1 0 LTD4_aw Kd_LTR1_FEV ML_airways_conc EC50_ML_FEV R2_portion_FEV LTD4_aw LTC4_aw_out Kd_LTR2_FEV 1 0 LTD4_aw LTC4_aw_out Kd_LTR2_FEV 1 0 R1_portion_FEV R2_portion_FEV Hn_aw Kd_Hn_FEV 1 0 Hn_aw Kd_Hn_FEV R1_portion_EOa LTD4_aw Kd_LT 1 0 LTD4_aw Kd_LT ML_airways_conc Ki_ML_EOa 1 0 R1_portion_EOa LTC4_aw_out LTD4_aw Kd_LT_2 1 0 LTC4_aw_out LTD4_aw Kd_LT_2 R1_portion_EOa fup_LT LTD4_b Kd_LT 1 0 fup_LT LTD4_b Kd_LT ML_blood_conc Ki_ML_EOa 1 0 R1_portion_EOa fup_LT LTC4_b_out LTD4_b Kd_LT_2 1 0 fup_LT LTC4_b_out LTD4_b Kd_LT_2 1 0 NADP_aw Kd_hedh_NADP oxoETE_aw Kd_hedh_oxoETE5 k_hedh_1 HETE_aw Kd_hedh_HETE5 k_hedh_4 NADPH_aw Kd_hedh_NADPH C_hedh_aw Et_LTCs K_LTC k_LTCs_fow LTA4_aw GSH_aw k_LTCs_back K_LTA_GSH K_GSH LTC4_aw 1 0 LTA4_aw K_LTA GSH_aw K_GSH LTA4_aw GSH_aw K_LTA K_LTA_GSH LTC4_aw K_LTC GSH_aw GSH_aw Km_gpx_GSH Km_gpx_GSH 1 0 GSSG_aw Kd_gpx_GSSG HPETE_aw Km_gpx_HPETE5 1 0 HETE_aw Kd_gpx_HETE5 C_aw 1 0 Ca K_Ca3 1 0 REDOX_aw 1 0 Ca K_Ca2 1 0 Ca K_Ca3 AA_aw K_AA 1 0 AA_aw Ki_AA_AA AA_aw Ki_AA 1 0 HETE_aw K_AA_HETE RELFLO5_aw 1 0 AA_aw Ki_HPETE_AA HETE_aw Ki_HETE al ZF_airways_conc KdZ r2 Ke_red r1 OH_aw Ke_ox al ki ZF_airways_conc KdZ 1 0 Ca K_Ca3 r2 r1 OOH_aw k_hedh_1 k_hedh_2 HETE_b NADP_b Kd_hedh_HETE5 Kd_hedh_NADP oxoETE_b NADPH_b k_hedh_3 k_hedh_4 Kd_hedh_oxoETE5 Kd_hedh_NADPH 1 0 NADP_b Kd_hedh_NADP oxoETE_b Kd_hedh_oxoETE5 k_hedh_1 HETE_b Kd_hedh_HETE5 k_hedh_4 NADPH_b Kd_hedh_NADPH C_hedh_b delta_LTCs_b K_LTA_GSH K_GSH K_LTC Et_LTCs K_LTC k_LTCs_fow LTA4_b GSH_b k_LTCs_back K_LTA_GSH K_GSH LTC4_b k_gpx_cat HPETE_b GSH_b GSH_b Km_gpx_HPETE5 Km_gpx_GSH Km_gpx_GSH GSH_b GSH_b Km_gpx_GSH Km_gpx_GSH 1 0 GSSG_b Kd_gpx_GSSG HPETE_b Km_gpx_HPETE5 1 0 HETE_b Kd_gpx_HETE5 C_b 1 0 Ca K_Ca3 1 0 REDOX_b 1 0 Ca K_Ca2 1 0 Ca K_Ca3 AA_b K_AA 1 0 AA_b Ki_AA_AA AA_b Ki_AA 1 0 HETE_b K_AA_HETE RELFLO5_b 1 0 AA_b Ki_HPETE_AA HETE_b Ki_HETE al ZF_blood_conc KdZ r2 Ke_red r1 OH_b Ke_ox al ki ZF_blood_conc KdZ 1 0 Ca K_Ca3 r2 r1 OOH_b Ki_HETE Ca K_PLA2_Ca PLA2_D NP_pool_b NADP_b naEO_LTCsyn EO_aw EO_i_aw EO_a_aw N_A_pmole w_EO V_AW EO_a_aw EO_aw EO_i_aw N_A_pmole w_EO V_AW naEO_LTCsyn EO_b EO_i_b EO_a_b N_A_pmole w_EO V_B EO_a_b EO_b EO_i_b N_A_pmole w_EO V_B time T time 3.6 2 T time 6.6 2 T time 9.6 2 T Default Vmax_PLA2 PLA2_Ca PL Km_PLA2_APC PL V_CoA AA_b Km_CoA_AA AA_b Default Kd50 LTC4_b Default Kd50 LTC4_b V_LTC_CB 1 1 6 0 Vd_LTC k_ggt fup_LT LTC4_b_out Vd_LTD k_dp fup_LT LTD4_b Vd_LTC k_ltc_ltd_el fup_LT LTC4_b_out Vd_LTD k_ltc_ltd_el fup_LT LTD4_b Vd_LTE k_lte_el k_acet fup_LT LTE4_b ca V_B ka EO_b OL_b h_act EC50_act h_act OL_b h_act ca V_B k_EO_m EO_i_b ca V_B kia EO_a_b V_B k_EO_d EO_b Default k_lo AA_b FLO3t_b K_AA V_B k_EO_a_d EO_a_b V_B k_EO_t_baw EO_i_b Rec_occup_migr h_migr EC50_migr h_migr Rec_occup_migr h_migr V_B k_EO_t_baw EO_a_b Rec_occup_migr h_migr EC50_migr h_migr Rec_occup_migr h_migr V_B k_EO_t_baw EO_b Rec_occup_migr h_migr EC50_migr h_migr Rec_occup_migr h_migr V_B k_Hn_p EO_b EO_i_b EO_a_b Vd_Hn k_Hn_d fup_Hn Hn_b V_B k_IL_p EO_a_b Vd_IL5 k_IL_d IL_b k_IL_t_bbm IL_b IL_bm J_BM_lymfl IL_bm V_BM k1 IL_bm h_matur Km_1 h_matur IL_bm h_matur k1_min Default k_3 FLO5HP_b k3 FLO3t_b HPETE_b 1 0 AA_b Ki_AA ca V_BM k_EO_t_bmb EO_bm Default Vmax_PLA2 PLA2_Ca PL Km_PLA2_APC PL V_CoA AA_aw Km_CoA_AA AA_aw Default k_lo AA_aw FLO3t_aw K_AA Default k_3 FLO5HP_aw k3 FLO3t_aw HPETE_aw 1 0 AA_aw Ki_AA Default r1 HPETE_aw FLO2_aw HETE_aw FLO3_aw Ke_ox Default GPx B_aw A_aw Default k_lta_syn FLO5HP_aw Default nom_LTCs_aw den_LTCs_aw Default HEDH5 B_hedh_aw A_hedh_aw Default Kd12 LTA4_aw Default r1 HPETE_b FLO2_b HETE_b FLO3_b Ke_ox Default Kd50 LTC4_aw Default Kd50 LTC4_aw V_LTC_CAW 1 1 6 0 Vd_AW_LTC k_ggt LTC4_aw_out Vd_AW_LTD k_dp LTD4_aw Q_AW_blf R_LTE_B LTE4_aw R_LTE_AW Kp_LTE_AW LTE4_b Q_AW_blf R_LTD_B LTD4_aw R_LTD_AW Kp_LTD_AW LTD4_b Q_AW_blf R_LTC_B LTC4_aw_out R_LTC_AW Kp_LTC_AW LTC4_b_out ca V_AW ka EO_aw OL_aw h_act EC50_act h_act OL_aw h_act ca V_AW k_EO_m EO_i_aw ca V_AW kia EO_a_aw V_AW k_EO_d EO_aw Default GPx B_b A_b V_AW k_EO_a_d EO_a_aw V_AW k_Hn_p EO_a_aw EO_i_aw EO_aw Q_AW_blf R_Hn_B Hn_aw R_Hn_AW Kp_Hn_AW Hn_b V_AW k_IL_p EO_a_aw k_IL_t_awb IL_aw IL_b J_AW_lymfl IL_aw Vd_AW_LTE k_lte_el k_acet LTE4_aw Vd_AW_LTD k_ltc_ltd_el LTD4_aw Vd_AW_LTC k_ltc_ltd_el LTC4_aw_out V_AW k_IL_d IL_aw Vd_AW_Hn k_Hn_d Hn_aw Default k_lta_syn FLO5HP_b Default k_abs_zf ZF_intes oral F_zf a ft_zf 1 0 a DOSE_zf 1 3 M_ZF Q_AW_blf R_ZF_B ZF_blood ZF_airways R_ZF_AW Kp_ZF_AW Vd_ZF k_elim_zf ZF_blood Default k_abs_ml ML_intes oral F_ml a ft_ml 1 0 a DOSE_ml 1 9 M_ML Vd_ML k_elim_ml ML_blood Default nom_LTCs_b den_LTCs_b Default HEDH5 B_hedh_b A_hedh_b Default Kd12 LTA4_b