Set cAMPlow=0.2 for nM ET, and cAMPlow=0.5 for pM ET

hinf h tauh

ETswitch 0.2 inh taudir

ica ik igirk cm

lambda ninf n taun

girk h V vk

gca minf V vca

kserca c

o cer c

1 1 c dinh

1 1 dact c

gk n V vk

inh cAMP c 4 ki 4 c 4

jerleak jerip3 kserca c

perl cer c

alpha gca 1 1 vm V sm V vca kc c

ainf 3 binf 3 hinfer 3

IP3 IP3 dip3

1 1 vh V sh

1 1 vn V sn

1 1 vm V sm

cell f jertot jmemtot

fer sigmav jertot cell

cell ETswitch cAMPlow cAMP taudir

At time 1 minute a nanomolar concentration of endothelin is added.

time 60000

1

3000

0.3