$v\mapsto v$ $\mathrm{Modifier}\mathrm{Substrat}\mathrm{Parameter}\mapsto \mathrm{Parameter}\mathrm{Modifier}\mathrm{Substrat}$ $\mathrm{Km}\mathrm{Ki}\mathrm{vmax}\mathrm{Inhibitor}\mapsto \frac{\mathrm{vmax}}{\mathrm{Km}^2+\left(\frac{\mathrm{Inhibitor}}{\mathrm{Ki}}\right)^2}$ $\mathrm{parameter}\mathrm{Activator}\mapsto \mathrm{parameter}\mathrm{Activator}$ $\mathrm{vmax}\mathrm{Activator}\mathrm{Km}\mathrm{vbasal}\mapsto \frac{\mathrm{vmax}\mathrm{Activator}^2}{\mathrm{Km}^2+\mathrm{Activator}^2}+\mathrm{vbasal}$ $\mathrm{vmax}\mathrm{Km}\mathrm{Inhibitor}\mathrm{Ki}\mathrm{Substrate}\mapsto \frac{\mathrm{vmax}}{\mathrm{Km}+\frac{\mathrm{Inhibitor}}{\mathrm{Ki}}}\mathrm{Substrate}$ $0$ $\mathrm{lambda}$ $\mathrm{Dshtotal}-\mathrm{Dsha}$ $\mathrm{APCtotal}-\mathrm{GSKtotal}+\mathrm{GSK3}-\mathrm{APC\_Axin}-\mathrm{APC}$ $\mathrm{GSKtotal}-\mathrm{APC\_Axin\_GSK3}+\mathrm{APC\_\_Axin\_\_GSK3}+\mathrm{GSK3}+\mathrm{APC\_\_Axin\_\_GSK3\_b\_catenin}+\mathrm{APC\_\_Axin\_\_GSK3\_b\_catenin\_\_HOS}+\mathrm{APC\_\_Axin\_\_GSK3\_b\_catenin\_\_FWD1}$ $\mathrm{Compartment}\mathrm{k1}\begin{cases}0 & \text{if $\mathrm{time}< 100000$}\\ e^{-\mathrm{ModelValue\_27}(\mathrm{time}-100000)} & \text{otherwise}\end{cases}\mathrm{Dshi}$ $\mathrm{Compartment}\mathrm{k10}\mathrm{APC\_\_Axin\_\_GSK3\_b\_catenin\_\_HOS}$ $\mathrm{Compartment}\mathrm{k10b}\mathrm{APC\_\_Axin\_\_GSK3\_b\_catenin\_\_FWD1}$ $\mathrm{Compartment}\mathrm{k11}\mathrm{b\_catenin\_\_ub}$ $\mathrm{Compartment}\mathrm{Constant\_flux\_\_irreversible}(\mathrm{v12})$ $\mathrm{Compartment}\mathrm{k13}\mathrm{b\_catenin}$ $\mathrm{Compartment}\mathrm{Constant\_flux\_\_irreversible}(\mathrm{v14})$ $\mathrm{Compartment}\mathrm{k15}\mathrm{Axin}$ $\mathrm{Compartment}(\mathrm{k16}\mathrm{TCF}\mathrm{b\_catenin}-\mathrm{k16r}\mathrm{b\_catenin\_TCF})$ $\mathrm{Compartment}(\mathrm{k17}\mathrm{APC}\mathrm{b\_catenin}-\mathrm{k17r}\mathrm{APC\_b\_catenin})$ $\mathrm{Compartment}\mathrm{Rate\_Law\_for\_reaction\_18}(\mathrm{Khos}, \mathrm{ki}, \mathrm{vmax18}, \mathrm{b\_catenin\_TCF})$ $\mathrm{Compartment}\mathrm{k19}\mathrm{HOSmRNA}$ $\mathrm{Compartment}\mathrm{k2}\mathrm{Dsha}$ $\mathrm{Compartment}\mathrm{Rate\_Law\_for\_reaction\_20\_25\_29}(\mathrm{k20}, \mathrm{HOSmRNA})$ $\mathrm{Compartment}\mathrm{k21}\mathrm{HOS}$ $\mathrm{Compartment}\mathrm{k22}\mathrm{HOS}\mathrm{APC\_\_Axin\_\_GSK3\_b\_catenin\_0}$ $\mathrm{Compartment}\mathrm{k22b}\mathrm{FWD1}\mathrm{APC\_\_Axin\_\_GSK3\_b\_catenin\_0}$ $\mathrm{Compartment}\mathrm{Rate\_Law\_for\_reaction\_23}(\mathrm{vmax23}, \mathrm{b\_catenin\_TCF}, \mathrm{Kcrd\_bp}, \mathrm{vbasal})$ $\mathrm{Compartment}\mathrm{k24}\mathrm{CRD\_BPmRNA}$ $\mathrm{Compartment}\mathrm{Rate\_Law\_for\_reaction\_20\_25\_29}(\mathrm{k25}, \mathrm{CRD\_BPmRNA})$ $\mathrm{Compartment}\mathrm{k26}\mathrm{CRD\_BP}$ $\mathrm{Compartment}\mathrm{Rate\_Law\_for\_reaction\_27}(\mathrm{k27}, \mathrm{Kfwd1}, \mathrm{CRD\_BP}, \mathrm{ki2}, \mathrm{FWD1mRNA})$ $\mathrm{Compartment}\mathrm{Constant\_flux\_\_irreversible}(\mathrm{v28})$ $\mathrm{Compartment}\mathrm{Rate\_Law\_for\_reaction\_20\_25\_29}(\mathrm{k29}, \mathrm{FWD1mRNA})$ $\mathrm{Compartment}\mathrm{Rate\_Law\_for\_reaction\_3}(\mathrm{Dsha}, \mathrm{APC\_Axin\_GSK3}, \mathrm{k3})$ $\mathrm{Compartment}\mathrm{k30}\mathrm{FWD1}$ $\mathrm{Compartment}\mathrm{Constant\_flux\_\_irreversible}(\mathrm{v31})$ $\mathrm{Compartment}\mathrm{k32}\mathrm{TCF}$ $\mathrm{Compartment}\mathrm{k4}\mathrm{APC\_Axin\_GSK3}$ $\mathrm{Compartment}\mathrm{k5}\mathrm{APC\_\_Axin\_\_GSK3}$ $\mathrm{Compartment}(\mathrm{k6}\mathrm{GSK3}\mathrm{APC\_Axin}-\mathrm{k6r}\mathrm{APC\_Axin\_GSK3})$ $\mathrm{Compartment}(\mathrm{k7}\mathrm{APC}\mathrm{Axin}-\mathrm{k7r}\mathrm{APC\_Axin})$ $\mathrm{Compartment}(\mathrm{k8}\mathrm{APC\_\_Axin\_\_GSK3}\mathrm{b\_catenin}-\mathrm{k8r}\mathrm{APC\_\_Axin\_\_GSK3\_b\_catenin})$ $\mathrm{Compartment}\mathrm{k9}\mathrm{APC\_\_Axin\_\_GSK3\_b\_catenin}$