v1
∅ = x
v2
x = ∅
v3
x = y
v4
y = ∅
v5
y = ∅
v6
∅ = z
v7
z = ∅
Assignment rules
v = 1000000.0*y
Function definitions
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
HIV-1 dynamics revisited: biphasic decay by cytotoxic T lymphocyte killing?
Proc. Biol. Sci. 2000;
267
(1450):
1347-1354
- PubMed: 10972131
- PubMed Central: PMC1690670
- DOI: 10.1098/rspb.2000.1149
- ISSN: 0962-8452
- URL: https://ncbi.nlm.nih.gov/pubmed/10972131
Abstract
The biphasic decay of blood viraemia in patients being treated for human immunodeficiency virus type 1 (HIV-1) infection has been explained as the decay of two distinct populations of cells: the rapid death of productively infected cells followed by the much slower elimination of a second population the identity of which remains unknown. Here we advance an alternative explanation based on the immune response against a single population of infected cells. We show that the biphasic decay can be explained simply, without invoking multiple compartments: viral load falls quickly while cytotoxic T lymphocytes (CTL) are still abundant, and more slowly as CTL disappear. We propose a method to test this idea, and develop a framework that is readily applicable to treatment of other infections.
No additional notes are available for this model.