FCdeg
FCdeg
FC > ∅
FCpdeg
FCpdeg
FCp > ∅
FCptrl
FCptrl
∅ > FCp
FCptrs
FCptrs
FCp = FNp
FCtrl
FCtrl
∅ > FC
FCtrs
FCtrs
FC = FN
MFdeg
MFdeg
MF > ∅
MFtrn
MFtrn
∅ > MF
Assignment rules
Tot_FRQ = FC + FCp + FN + FNp
Function definitions
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
Isoform switching facilitates period control in the Neurospora crassa circadian clock.
Mol. Syst. Biol. 2008;
4
:
164
- PubMed: 18277380
- PubMed Central: PMC2267733
- DOI: 10.1038/msb.2008.5
- ISSN: 1744-4292
- URL: https://ncbi.nlm.nih.gov/pubmed/18277380
Abstract
A striking and defining feature of circadian clocks is the small variation in period over a physiological range of temperatures. This is referred to as temperature compensation, although recent work has suggested that the variation observed is a specific, adaptive control of period. Moreover, given that many biological rate constants have a Q(10) of around 2, it is remarkable that such clocks remain rhythmic under significant temperature changes. We introduce a new mathematical model for the Neurospora crassa circadian network incorporating experimental work showing that temperature alters the balance of translation between a short and long form of the FREQUENCY (FRQ) protein. This is used to discuss period control and functionality for the Neurospora system. The model reproduces a broad range of key experimental data on temperature dependence and rhythmicity, both in wild-type and mutant strains. We present a simple mechanism utilising the presence of the FRQ isoforms (isoform switching) by which period control could have evolved, and argue that this regulatory structure may also increase the temperature range where the clock is robustly rhythmic.
The SBML for this model was obtained from the BioModels database (BioModels ID: BIOMD0000000295)
Biomodels notes: This model corresponds to "Model 1" of the reference publication. The model reproduces figure 5 in the supplementary material of the reference publication.
The model was integrated and simulated using Copasi v4.6 (Build 32).
JWS Online curation: This model was curated by reproducing the figures as described in the BioModels Notes. No additional changes were made.