initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek 0.5 kdphoss6 initTORC1 kas6t 1 RSKin kinrskb 1 Mekin kmekind 1 kdphoss6 2 initTORC1 2 kas6t 2 2 initTORC1 kas6t kdphoss6 RSKin kdphoss6 2 kinrskb Mekin kdphoss6 2 kmekind 4 initRSKtd initErkt32D initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek kpErk kpErk kppErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek 2 dDUSP3 lppErk kpErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek dDUSP3 lpErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek kppErk dDUSP3 lppErk karsk kas6r initTORC1 2 RSKin kas6t 2 kinrskb initTORC1 2 Mekin kas6t 2 kmekind 2 initTORC1 RSKin kas6t kdphoss6 kinrskb 2 initTORC1 Mekin kas6t kdphoss6 kmekind RSKin Mekin kdphoss6 2 kinrskb kmekind initTORC1 2 RSKin Mekin kas6t 2 kinrskb kmekind 2 initTORC1 RSKin Mekin kas6t kdphoss6 kinrskb kmekind 1 2 RSKin kdphoss6 kinrskb Mekin kdphoss6 kmekind initTORC1 RSKin kas6t kinrskb initTORC1 Mekin kas6t kmekind RSKin Mekin kdphoss6 kinrskb kmekind initTORC1 RSKin Mekin kas6t kinrskb kmekind kas6r RSKin kinrskb 1 Mekin kmekind 1 initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initAktt32D initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initPDK1t32D kPDK1 lPDK1 initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 kPDK1 kAkt vpAkt dpAkt lAkt dpAkt initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 kAkt dpAkt initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initPDK1t32D kPDK1 lPDK1 initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 kPDK1 vpAkt initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initPDK1t32D kPDK1 lPDK1 initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 kPDK1 kAkt vpAkt dpAkt initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initAktt32D kAkt dpAkt lAkt dpAkt initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 kAkt dpAkt initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initPDK1t32D kPDK1 lPDK1 initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 kPDK1 vpAkt initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initPDK1t32D kPDK1 lPDK1 initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 kPDK1 kAkt vpAkt initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 initPDK1t32D kPDK1 lPDK1 initPI45P232D vPIP3basal initRpPI3K initPI3Kt32D initRpGab2PI3K initPTEN32D vPI45P2 kshbasal initSHIP1t32D initRpSHIP1 kPDK1 initS6t32D kbacks6 initTORC1 kas6t 0.5 kdphoss6 initTORC1 kas6t 1 RSKin kinrskb 1 Mekin kmekind 1 kdphoss6 2 initTORC1 2 kas6t 2 2 initTORC1 kas6t kdphoss6 RSKin kdphoss6 2 kinrskb Mekin kdphoss6 2 kmekind 4 initRSKtd initErkt32D initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek kpErk kpErk kppErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek 2 dDUSP3 lppErk kpErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek dDUSP3 lpErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek kppErk dDUSP3 lppErk karsk kas6r initTORC1 2 RSKin kas6t 2 kinrskb initTORC1 2 Mekin kas6t 2 kmekind 2 initTORC1 RSKin kas6t kdphoss6 kinrskb 2 initTORC1 Mekin kas6t kdphoss6 kmekind RSKin Mekin kdphoss6 2 kinrskb kmekind initTORC1 2 RSKin Mekin kas6t 2 kinrskb kmekind 2 initTORC1 RSKin Mekin kas6t kdphoss6 kinrskb kmekind 1 2 RSKin kdphoss6 kinrskb Mekin kdphoss6 kmekind initTORC1 RSKin kas6t kinrskb initTORC1 Mekin kas6t kmekind RSKin Mekin kdphoss6 kinrskb kmekind initTORC1 RSKin Mekin kas6t kinrskb kmekind kas6r RSKin kinrskb 1 Mekin kmekind 1 kas6r kbacks6 kdphoss6 initTORC1 kas6t 0.5 kdphoss6 initTORC1 kas6t 1 RSKin kinrskb 1 Mekin kmekind 1 kdphoss6 2 initTORC1 2 kas6t 2 2 initTORC1 kas6t kdphoss6 RSKin kdphoss6 2 kinrskb Mekin kdphoss6 2 kmekind 4 initRSKtd initErkt32D initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek kpErk kpErk kppErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek 2 dDUSP3 lppErk kpErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek dDUSP3 lpErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek kppErk dDUSP3 lppErk karsk kas6r initTORC1 2 RSKin kas6t 2 kinrskb initTORC1 2 Mekin kas6t 2 kmekind 2 initTORC1 RSKin kas6t kdphoss6 kinrskb 2 initTORC1 Mekin kas6t kdphoss6 kmekind RSKin Mekin kdphoss6 2 kinrskb kmekind initTORC1 2 RSKin Mekin kas6t 2 kinrskb kmekind 2 initTORC1 RSKin Mekin kas6t kdphoss6 kinrskb kmekind 1 2 RSKin kdphoss6 kinrskb Mekin kdphoss6 kmekind initTORC1 RSKin kas6t kinrskb initTORC1 Mekin kas6t kmekind RSKin Mekin kdphoss6 kinrskb kmekind initTORC1 RSKin Mekin kas6t kinrskb kmekind kas6r RSKin kinrskb 1 Mekin kmekind 1 kas6r initErkt32D initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek kpErk kpErk kppErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek 2 dDUSP3 lppErk kpErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek dDUSP3 lpErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek kppErk dDUSP3 lppErk initRast32D kbackRas kbackRas kdRas initRast32D initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek initAktt32D initErkt32D initMekt32D initPDK1t32D initPI3Kt32D initPI45P232D initPTEN32D initRaft32D initErkt32D initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek kpErk kpErk kppErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek 2 dDUSP3 lppErk kpErk initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf initMekt32D kpMek kpMek kppMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf 2 lppMek kpMek initRaft32D initRast32D kbackRas kbackRas kdRas kpRaf kpRaf lpRaf lpMek kppMek lppMek dDUSP3 lpErk 532.9197 pS6 Epodegradation BaF3Epo kSHIP1 SHIP1t32D RpSHIP1 pEpoR RpSHIP1 lSHIP1 RpSHIP1 EpoRactivation1 1 phos2 Ki1 EpoR32D pEpoR 1 kPI3K 1 kPI3K 1 kPI3K kPI3Kras 1 kPI3K kPI3Kras 1 kPI3K 1 kPI3K kPI3Kras 1 BaF3Epo nb ksatb nb BaF3Epo nb vPIP3 PI45P232D kPI3K 1 kPI3K 1 kPI3K kPI3Kras 1 pEpoR vPIP3 main1 PI45P232D kPI3K kPI3Kras 1 kPI3K 1 kPI3K kPI3Kras 1 pEpoR kshbasal PIP3 SHIP1t32D RpSHIP1 vPI45P2 PIP3 PTEN32D vPI34P2 PIP3 RpSHIP1 kPDK1 PIP3 PDK1t32D PIP3PDK1 lPDK1 PIP3PDK1 kAkt PIP3 Aktt32D PIP3Akt pAkt lAkt PIP3Akt vpAkt PIP3Akt PIP3PDK1 Phosphataseactivation1 Phosphataset32D actPhosphatase pEpoR vpAkt PIP3Akt PIP3PDK1 vpAkt PIP3Akt PIP3PDK1 1 kaktind Aktin dpAkt pAkt vPIP3basal PI45P232D PI3Kt32D kPI3K 1 kPI3K 1 kPI3K kPI3Kras 1 pEpoR kPI3K kPI3Kras 1 kPI3K 1 kPI3K kPI3Kras 1 pEpoR vPIP3basal main1 PI45P232D kpes Sostb pSos RpSos ppErk kdpes pSos kSos Sostb RpSos pSos pEpoR RpSos lSos RpSos kpes RpSos ppErk Phosphatasedeactivation1 actPhosphatase kbackRas Rast32D GTPRas kPI3K kPI3Kras 1 kPI3K 1 kPI3K kPI3Kras 1 pEpoR kaRas RpSos Rast32D GTPRas kPI3K kPI3Kras 1 kPI3K 1 kPI3K kPI3Kras 1 pEpoR kdRas GTPRas kpRaf GTPRas kPI3K kPI3Kras 1 kPI3K 1 kPI3K kPI3Kras 1 pEpoR Raft32D pRaf lpRaf pRaf kpMek pRaf Mekt32D pMek ppMek lpMek pMek kppMek pRaf pMek lppMek ppMek kpErk ppMek Erkt32D pErk ppErk pEpoRdeactivation1 pEpoR actPhosphatase lpErk dDUSP3 pErk kppErk ppMek pErk 1 kmekind Mekin lppErk dDUSP3 ppErk ppErk pAkt kvpakt pAkt mTORt mTORa TORC1 TORC2 kvppErk RSKa 1 kinrskb RSKin mTORt mTORa TORC1 TORC2 kdactm mTORa kst1 1 kinrapab Rapamycin mTORa TORC1 TORC2 Raptord TORC1 kdt1 TORC1 Phosact1 pEpoR n1 Ji1 n1 pEpoR n1 kdactm TORC1 kst2 mTORa TORC2 TORC1 Rictord TORC2 kdt2 TORC2 kdactm TORC2 karsk 1 kinrskb RSKin RSKtd RSKa ppErk kdrsk RSKa kas6t TORC1 S6t32D pS6 kas6r RSKa S6t32D pS6 kbacks6 S6t32D pS6 kdphoss6 pS6 Phosdeact1 phos2 pdk2correct cycleaktind pAkt cyclemekind ppErk maxccd pdoffcorrect 60 pS6