v1
v1
∅ = pEpoR
v17
v17
∅ = RpSHIP1
v18
RpSHIP1 = ∅
v19
v19
∅ = PIP3
v2
v2
∅ = actPhosphatase
v20
v20
∅ = PIP3
v21
v21
PIP3 = ∅
v22
v22
PIP3 = ∅
v23
v23
PIP3 = ∅
v24
v24
PIP3 = PIP3PDK1
v25
PIP3PDK1 = PIP3
v26
v26
PIP3 = PIP3Akt
v27
PIP3Akt = PIP3
v28
v28
PIP3Akt = ∅
v29
v29
∅ = PIP3
v3
actPhosphatase = ∅
v30
v30
∅ = pAkt
v31
pAkt = ∅
v32
v32
∅ = PIP3
v33
v33
∅ = PIP3
v34
v34
∅ = pSos
v35
pSos = ∅
v36
v36
∅ = RpSos
v37
RpSos = ∅
v38
v38
RpSos = pSos
v39
v39
∅ = GTPRas
v4
v4
pEpoR = ∅
v40
v40
∅ = GTPRas
v41
GTPRas = ∅
v42
v42
∅ = pRaf
v43
pRaf = ∅
v44
v44
∅ = pMek
v45
pMek = ∅
v46
v46
pMek = ppMek
v47
ppMek = pMek
v48
v48
∅ = pErk
v49
pErk = ∅
v5
v5
∅ = phos2
v50
v50
pErk = ppErk
v51
ppErk = pErk
v52
v52
∅ = Intperk
v53
v53
∅ = Intpakt
v54
v54
∅ = mTORa
v55
v55
∅ = mTORa
v56
mTORa = ∅
v57
v57
mTORa = TORC1
v58
TORC1 = mTORa
v59
TORC1 = ∅
v6
phos2 = ∅
v60
v60
mTORa = TORC2
v61
TORC2 = ∅
v62
TORC2 = mTORa
v63
v63
∅ = RSKa
v64
RSKa = ∅
v65
v65
∅ = pS6
v66
v66
∅ = pS6
v67
v67
∅ = pS6
v68
pS6 = ∅
v69
v69
∅ = Proliferation
v70
v70
∅ = IntpS6
Assignment rules
pS6plot = 270.9568*pS6
Function definitions
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
