R10_drug_washout
R10_drug_washout
drug + washout > washout
R11_FLC_drug_binding
R11_FLC_drug_binding
drug + FLC = FLC_drug
R12_FLC_drug_washout
R12_FLC_drug_washout
FLC_drug + washout > washout
R13_CRA_Secretion_DyingFibr
R13_CRA_Secretion_DyingFibr
DyingFibr > CRA
R14_CRAClipOffHealthyFibr
R14_CRAClipOffHealthyFibr
HealthyFibr + MMP7 > CRA + MMP7 + HealthyFibr
R15_DyingFibroblast_death
R15_DyingFibroblast_death
DyingFibr > ∅
R16_Healthy_to_Dying_fibroblast
R16_Healthy_to_Dying_fibroblast
HealthyFibr + TNFalpha > DyingFibr + TNFalpha
R17_HealthyBacteriaProduction
R17_HealthyBacteriaProduction
HealthyBacteria > {2.0}HealthyBacteria
R18_HealthyFibProduction
R18_HealthyFibProduction
free_space + HealthyFibr > {2.0}HealthyFibr
R19_MMP7_release_HealthyFibr
R19_MMP7_release_HealthyFibr
HealthyFibr > HealthyFibr + MMP7
R1_CRA_degradation
R1_CRA_degradation
CRA + MMP8 > MMP8
R20_MMP8_release_HealthyFibr
R20_MMP8_release_HealthyFibr
HealthyFibr > HealthyFibr + {100.0}MMP8
R21_Healthy_to_Dying_Bacteria
R21_Healthy_to_Dying_Bacteria
HealthyBacteria + Protease > DyingBacteria + Protease
R22_CRA_binding
R22_CRA_binding
MastCells_FLC + CRA = MastCells_FLC_CRA
R23_FLC_binding
R23_FLC_binding
FLC + MastCells = MastCells_FLC
R24_TNFalpha_production
R24_TNFalpha_production
MastCells_FLC_CRA > TNFalpha + MastCells_FLC_CRA
R25_Protease_production
R25_Protease_production
MastCells_FLC_CRA > Protease + MastCells_FLC_CRA
R26_DyingBacteria_secrete_CRA
R26_DyingBacteria secrete CRA
DyingBacteria > {1000.0}CRA
R27_Dyingbacteria_die
R27_Dyingbacteria die
DyingBacteria > ∅
R28_Proteaseinflux
R28_Proteaseinflux
∅ > Protease
R2_CRA_washout
R2_CRA_washout
CRA + washout > washout
R3_CRAinflux
R3_CRAinflux
∅ > CRA
R4_FLC_washout
R4_FLC_washout
FLC + washout > washout
R5_MMP7_washout
R5_MMP7_washout
MMP7 + washout > washout
R6_MMP8_washout
R6_MMP8_washout
MMP8 + washout > washout
R7_Protease_washout
R7_Protease_washout
Protease + washout > washout
R8_TNFalpha_washout
R8_TNFalpha_washout
TNFalpha + washout > washout
R9_FLC_production
R9_FLC_production
CRA + Bcells > FLC + CRA + Bcells
Assignment rules
free_space = Metabolite_18 - (HealthyFibr + DyingFibr)
Total_space = Metabolite_18
Function definitions
Rate_Law_for_BAFF_clipoff(k1, s1, s2) = k1 * s1 * s2
Rate_Law_for_B_FLC_production(k1, s1, s2) = k1 * s1 * s2
Constant_flux__irreversible(v) = v
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
No manuscript information is available for this model.